Navigation Links
Studies Investigate Emerging Trends and Treatment Options for Patients With Sickle Cell Disease
Date:12/6/2009

e with Sildenafil Therapy) was conducted in 10 medical centers in the United States and United Kingdom to test this application in adults and children over 12 years of age with sickle cell disease.

Before starting treatment, potential study participants were given baseline tests, including a Doppler echocardiogram and a six-minute walk test to measure heart and lung function. Seventy-four patients who had a tricuspid regurgitant jet velocity (TRV) of greater than or equal to 2.7 m/s (a sign of suspected high pulmonary blood pressure) and a six-minute walking distance of only 150-500 meters (reflecting decreased exercise capacity) were included in the study. The researchers then randomly assigned the study participants into two groups of 37 patients each. Half of the patients were treated with sildenafil at escalating doses from 20, 40, and 80 mg three times per day, and the other half received a placebo three times per day. In previous studies of patients with primary pulmonary hypertension, the highest dose of sildenafil (80 mg) had the greatest effect on blood circulation; however, to monitor for possible adverse effects associated with escalating doses, the sildenafil doses in this study were increased slowly, with dose increases made every four weeks.

The study was prematurely stopped when a significant number of the patients in the sildenafil treatment arm (46 percent) began experiencing serious side effects (primarily sickle cell pain crises requiring hospitalization), compared with only 22 percent of those in the placebo arm. Headache and blurred vision, which were expected side effects of sildenafil, were also experienced. The patients in the sildenafil group had more headaches (27 percent versus 14 percent) and more blurred vision (11 percent versus 3 percent) than the placebo group.

Prior to stopping the study, 33 patients had completed the 16-week assessment and were found to have no change in TRV value or in the walkin
'/>"/>

SOURCE American Society of Hematology
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effective in Reducing Recurrent, Unexplained Miscarriages
2. Genomic Health to Present Five New Studies at 32nd Annual San Antonio Breast Cancer Symposium
3. Brandeis studies evaluate visionary approach to improving eyesight
4. Ninety Percent of All Vaccine Preventable Deaths Occur in Those 65 and Older According to Highlighted Studies in the December Patient Safety Advisory
5. Acuo Technologies Announces a New Offering That Enables Sharing of Imaging Studies Securely and Affordably
6. The straight dope: Studies link parental monitoring with decreased teen marijuana usage
7. Climate studies to benefit from 12 years of satellite aerosol data
8. Indiana U. at APHA: Studies about why men and women use lubricants during sex
9. Federal stimulus funds support studies geared to improving HIV care and prevention
10. New studies explore connection between high stress jobs and GI disorders
11. Practice-changing cancer studies presented at major cancer meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 26, 2014 “Every three months the ... changes. A-line sweetheart evening dress will be one of the ... manager of Yunx.co.uk says. Today, the company releases 26 A-line ... up to 80% off. , “We are trying our ... style with our latest designs. Along with affordable prices, we ...
(Date:12/25/2014)... December 25, 2014 The short film “Color ... created in honor of a true 9/11 hero, Welles Remy ... festivals including the 24 hours of Nuremberg International Short Film ... , Actress, screenwriter and director Luciana Lagana ... film together with her husband, Gregory Graham - ...
(Date:12/25/2014)... Woodland Hills, California (PRWEB) December 25, 2014 ... in her home in Woodland Hills, California after an ... Harris passed away on Christmas Eve evening in her ... battle with aggressive metastatic breast cancer. ... International for over forty years, she pioneered and championed ...
(Date:12/25/2014)... Dennis Thompson HealthDay Reporter ... sick children with complex chronic illnesses can receive effective, less ... home," with easy access to a team of dedicated health ... likely to become seriously ill and need either hospitalization or ... at an enhanced medical home clinic at the University of ...
(Date:12/25/2014)... News) -- Among early stage breast cancer patients who ... one percent will eventually develop leukemia as a result ... finding comes from a review of more than 20,000 ... it suggests that the risk for developing treatment-related leukemia, ... thought. "The frequency of bone marrow cancers such ...
Breaking Medicine News(10 mins):Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... N.J., Feb. 17 Novo Nordisk, a global healthcare ... of Andy Ajello as vice president for National Diabetes ... Executive Team and will report directly to Jerzy Gruhn, ... recently the associate vice president of Diabetes Sales for ...
... Little known language in the economic stimulus ... efforts by nonprofit hospitals - resulting in fewer ... of essential health care services provided to the ... the 11th hour thanks to the efforts of ...
... CryoLife, Inc. (NYSE: CRY ), a,biomaterials, medical ... Food and Drug Administration (FDA) has cleared a new ... The new labeling claim,relates to reducing a component of ... CryoValve SG pulmonary human heart ...
... Year,s Most Common ClaimsBREA, Calif., Feb. 17 Not ... and cuddly. Take ear infections, for example, or skin ... (VPI), the nation,s oldest and largest provider of pet ... to find the year,s most common pet maladies. The ...
... "natural" ingredients should be regarded as a driver for ... 17 According to Kline & Company,s study ... 2008: U.S. and Europe , botanicals consumption is growing ... average growth of 5.4%. The increased use of botanicals ...
... DIEGO, Feb. 17 Tracon Pharmaceuticals, a biotechnology company ... announced today that its three clinical stage cancer therapeutics ... 100th Annual Meeting of the American Association for Cancer ... program targets a unique pathway with the potential for ...
Cached Medicine News:Health News:Novo Nordisk Appoints Andy Ajello as Vice President for National Diabetes Sales, Managed Care and Government Accounts 2Health News:Philanthropic Fundraising Activities in Stimulus Bill Preserved Thanks to the Efforts of the Association for Healthcare Philanthropy 2Health News:FDA Clears New Immune Response Claim for the CryoValve(R) SG Pulmonary Human Heart Valve 2Health News:FDA Clears New Immune Response Claim for the CryoValve(R) SG Pulmonary Human Heart Valve 3Health News:Sick as a Dog: Pets' Top Medical Conditions of 2008 2Health News:Sick as a Dog: Pets' Top Medical Conditions of 2008 3Health News:Desire for Performance Coupled With Natural Ingredients Boosts Botanical Actives Consumption in Personal Care 2Health News:Desire for Performance Coupled With Natural Ingredients Boosts Botanical Actives Consumption in Personal Care 3Health News:Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009 2Health News:Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009 3
(Date:12/24/2014)... , Dec. 23, 2014  The American Diabetes ... pressure target for people with diabetes and that ... high doses of statins, in keeping with recent ... by the American College of Cardiology (ACC) and ... in the most recent changes to the Association,s ...
(Date:12/24/2014)... HILL, N.C. , Dec. 23, 2014  Medical ... success. As the key link between the medical device ... grow even more in the coming years as the ... According to research by benchmarking firm, ... MSLs can gain an important edge is by harnessing ...
(Date:12/22/2014)... Research and Markets ( http://www.researchandmarkets.com/research/h3xm6q/us ) ... Blood Glucose Market" report to their offering. ... market insight focuses on the developments in the self-monitoring ... . Reimbursement analysis and the effects of competitive ... than 73 SMBG meters have been performed, based on ...
Breaking Medicine Technology:New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4Role of Medical Science Liaisons Evolving in Medical Device Sector 2US Self-monitoring Blood Glucose Market 2
... ,Since the first system was invented in ... and patient care. During the 1960s, blood gas ... were considered "the most important laboratory test for ... by Dr. John Severinghaus, inventor of the blood ...
... ,Contributing Editor , ,Positive patient identification (ID) is ... few years. Until recently, the costs associated with hardware ... or laboratory. Today there are multiple vendors with devices ... ease. Some systems are better for small facilities, while ...
Cached Medicine Technology:Blood Gas Analysis: The Pros and Cons of Point-Of-Care Testing 2Blood Gas Analysis: The Pros and Cons of Point-Of-Care Testing 3Blood Gas Analysis: The Pros and Cons of Point-Of-Care Testing 4Managing Preanalytical Processes for Patient Safety 2Managing Preanalytical Processes for Patient Safety 3Managing Preanalytical Processes for Patient Safety 4
... lightweight self-adhesive insulin pod that you fill with ... up to three days and then replace. The ... your body through a small flexible tube (called ... into its wireless companion, the Personal Diabetes Manager. ...
The MiniMed Paradigm REAL-Time System is the world's first system to integrate an insulin pump with REAL-Time continuous glucose monitoring, taking diabetes management to a level you just can't achie...
The IR 1000 Insulin Infusion Pump from Animas offers unprecedented safety features, performance, and convenience....
... Radiancys premium product for acne, ... clinical results on a scalable multi-application ... fight against acne, XtremeClear works fast, ... first few treatments. Uncompromising safety in ...
Medicine Products: