Navigation Links
Studies Decipher How Anti-Smoking Drugs Work
Date:1/3/2011

MONDAY, Jan.3 (HealthDay News) -- Two drugs that help people stop smoking -- bupropion and varenicline -- may change the way the brain reacts to seeing someone else smoke, new studies report.

And that may be how they cut cravings.

Bupropion (Wellbutrin, Zyban) is prescribed around the world to help people resist smoking cues. But it has not been clear how the drug does this. Using brain scans, Christopher S. Culbertson, of the University of California, Los Angeles, and his colleagues examined what happened in the brains of 30 smokers who took the drug or a placebo for eight weeks.

The researchers gauged how much the participants craved cigarettes by asking them to respond after watching "neutral" cues that did not involve smoking or 45-second videos of actors and actresses smoking.

Those who took the drug instead of the placebo reported less craving. They also showed less activity in areas of the brain linked to craving.

"These results demonstrate that treatment with bupropion is associated with an improved ability to resist cue-induced craving and a reduction in cue-induced activation of limbic and prefrontal brain regions," the study authors wrote.

In a second study, Teresa Franklin of the University of Pennsylvania and her colleagues used brain scans to study how the brains of 22 smokers reacted when they took the drug varenicline (Chantix) or a placebo for three weeks. The participants watched 10-minute videos, some of which included smoking cues.

Those who took the drug had less brain activity in some areas and reported less craving after they saw the videos designed to provide smoking cues.

"The results of our study reveal a distinctive new action of varenicline that may contribute to its clinical efficacy," the researchers wrote. "Unsuccessful smoking cessation is more prevalent in individuals with psychiatric illness, suggesting that they have greater difficulty quitting. Varenicline and other medications that can reduce both withdrawal and cue reactivity may be of special benefit to these subgroups."

Both studies were published online Jan. 3 in the Archives of General Psychiatry.

More information

The American Cancer Society has information on quitting smoking.

-- Randy Dotinga

SOURCE: Archives of General Psychiatry, news release, Jan. 3, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New trial studies link between stroke and atrial fibrillation
2. John Theurer Cancer Center presents studies on promising therapies for aggressive blood cancers
3. Studies highlight role of stem cell transplant procedures for blood cancer treatment
4. 2 studies provide insight into stroke risk and prevention in young sickle cell anemia patients
5. Drug-like compound stops thyroid overstimulation in early NIH studies
6. Laboratory studies show promise for new multiple sclerosis treatment
7. A Little Alcohol May Help the Heart: Studies
8. Studies validate use of family health history as gold standard in disease risk assessment
9. Researchers find pathway that drives spread of pediatric bone cancer in preclinical studies
10. Practice-changing studies on how oncologists treat cancer to be presented at ASTRO Annual Meeting
11. Studies show everolimus-eluting stent implantation reduces restenosis and repeat revasculariztion
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Studies Decipher How Anti-Smoking Drugs Work
(Date:2/13/2016)... ... ... DDi , a Makro company, makes it to ... in eClinical Solutions. DDi has built its solution competency with a unique blend ... DDi provides smarter technology for Clinical Development, Regulatory and Enterprise domains by providing ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... devoted exclusively to funding innovative lymphoma research and serving the lymphoma community through ... over 250 members of South Florida’s philanthropic community at its 10th anniversary Fashion ...
(Date:2/12/2016)... ... 2016 , ... Coco Libre, the maker of coconut water beverages with a ... Lounge Event. Coco Libre will offer musicians and celebrities the company’s signature Organic Coconut ... invitation-only gifting suite, held this year at the W Hollywood Hotel, has become a ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fisher House Foundation Chairman ... John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns Director, ... VA Southern Nevada Healthcare System. This will be the first Fisher House in ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young ... area, celebrates the beginning of the latest charity campaign in their community enrichment ... art. Donations to this worthy cause are currently being accepted at: http://artexpressioninc.org/ ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Kalifornien, 12. Februar 2016  Sequent ... der Aufnahme von Patienten für eine Studie zur ... Aneurysmen („WEB") speziell für die Behandlung von rupturierten ... , MD, Leiter der Neuroradiologie an der Universitätsklinik ... und Hauptprüfarzt der CLARYS-Studie hat den ersten Patienten ...
(Date:2/12/2016)... , Feb. 12, 2016  Eli Lilly and Company ... Court decided the Alimta® (pemetrexed disodium) vitamin regimen patent would ... the UK, France , Italy ... to dilute the product only with dextrose solution.  ... 2015, the UK Court of Appeal held that Lilly,s patent ...
(Date:2/12/2016)... BUDAPEST , Ungarn, February 12, 2016 ... ein Medizintechnikunternehmen, das sich auf den ungedeckten ... gab heute positive Ergebnisse seines klinischen Forschungsprogramms ... und Asthma-Patienten beschäftigt, ergab Verbesserungen ihrer respiratorischen ... Indiso ltd , ein Medizintechnikunternehmen, das ...
Breaking Medicine Technology: