Navigation Links
Structures from the human immune system's oldest branch shed light on a range of diseases
Date:6/17/2009

PHILADELPHIA How molecules of the oldest branch of the human immune system have interconnected has remained a mystery. Now, two new structures, both involving a central component of an enzyme important to the complement system of the immune response, reveal how this system fights invading microbes while avoiding problems of the body attacking itself.

The structures may pave the way to more efficient therapeutics for such complement-mediated diseases as age-related macular degeneration, rheumatoid arthritis, or systemic lupus erythematosus, as well as give insight into the pathogenesis of other immune and inflammatory diseases.

The complement system, an evolutionarily old arm of the immune system, comprises a network of proteins that "complement" the work of antibodies in destroying foreign invaders. They serve as a rapid defense mechanism in most species, from primitive sponges to humans. When complement proteins are triggered into action by a microbe, the proteins ultimately form a complex enzyme called C3 convertase, initiating a cascade of immune and inflammatory reactions. In order to avoid self-attack, regulatory proteins such as factor H bind with C3b, a central component of C3, to help the immune system recognize the body's own tissue and keep complement in check.

Researchers at the University of Pennsylvania School of Medicine, in collaboration with colleagues at Utrecht University in the Netherlands, have determined the structure of C3 convertase and of the C3b fragment in complex with factor H. The work appears this month in two companion papers in Nature Immunology.

"Research on the complement system has waited more than 30 years for these structures," says senior author John Lambris, PhD, the Dr. Ralph and Sallie Weaver Professor of Research Medicine at Penn.

In the case of the C3 convertase structure, the researchers were able to make crystals by stabilizing the convertase complex with an inhibit
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Smart insulin nanostructures pass feasibility test, UT study reports
2. Pharmos Restructures Operations in Israel
3. Health Capital Group Warns of Fallout to Hospitals From the Subprime Mortgage Crisis and Urges Hospitals to Immediately Reassess Existing Debt Structures and Capital Financing Plans
4. Porous structures help boost integration of host tissue with implants, study finds
5. Titanium Group Implements Biometric Sign-On Infrastructures for Hong Kong Immigration Department
6. New technique takes a big step in examination of small structures
7. VaxGen Restructures Following Termination of Proposed Merger
8. Nanostructures improve bone response to titanium implants
9. Computer-Based Method IDs Alzheimers Protein Structures
10. NewCardio Restructures 2007 Financing, Receives $2.8 Million Additional Cash and Improves Capital Structure
11. eFoodSafety.com Restructures purEffect(TM) Marketing Agreement with CK41
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Structures from the human immune system's oldest branch shed light on a range of diseases
(Date:12/25/2014)... Product liability lawsuits filed in the ... http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal court, ... in the U.S. District Court, Northern District of Ohio ... conference on January 7, 2015, at the Paul G. ... Palm Beach, Florida. The Conference is scheduled to begin ...
(Date:12/25/2014)... 25, 2014 The short film “Color of ... in honor of a true 9/11 hero, Welles Remy Crowther. ... including the 24 hours of Nuremberg International Short Film Festival ... , Actress, screenwriter and director Luciana Lagana plays ... together with her husband, Gregory Graham - Graham ...
(Date:12/25/2014)... 25, 2014 When head lice hits a ... a frenzy to get rid of it while keeping it ... Coral Gables now have the solution right in their neighborhood: ... location, Lice Troopers provides full spectrum head lice screening and ... area, including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest ...
(Date:12/25/2014)... common during the holidays, but there are strategies that can ... arrive at a party hungry. It may seem logical to ... party, but deprivation leads to hunger, and hunger leads to ... Mount Kisco, N.Y., said in a hospital news release. ... to have a snack before attending a party when you ...
(Date:12/25/2014)... 25, 2014 Thousands of transvaginal mesh ... in a number of multidistrict litigations currently underway in ... Liebhard LLP reports. According to an Order issued on ... a Joint Status Conference in all of the proceedings ... been directed to submit a proposed agenda to the ...
Breaking Medicine News(10 mins):Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4
... lumpectomy linked to depression, fear, study finds , , WEDNESDAY, ... who opt for breast-conserving cancer surgery say they now ... their quality of life, a new study says. , ... were twice as likely to fear their cancer returning ...
... jump in number of those over 70 who are ,doing ... comes to sex, grandma and grandpa are having more of ... the study, the last quarter century has seen a dramatic ... whether married or unmarried. And as an added bonus, seniors ...
... MLAB ) announced today that it has been ... of the 100 fastest-growing,publicly held small companies in the ... with annual revenues of less than $200 million and,rank ... and stock,performance over the past three years. This was ...
... -- China Medicine,Corporation (OTC Bulletin Board: CHME; ... leading distributor and developer of ethical and,over-the-counter ... supplements, medical devices, and medical formulations in ... that it released a white,paper on Recombinant ...
... 9 Nyer Medical Group,Inc. (Nasdaq: NYER ... Medical Supplies,Inc., ("ADCO South") its Florida Medical-Surgical division. ... was awarded a two-year,contract with Sunrise Senior Living, ... 16 of the company,s Assisted Living Facilities in,Massachusetts. ...
... Texas, July 9 SKINTASTIC(TM),Medical and Surgical Rejuvenation ... FDA-approved EVOLENCE(R) -- the latest injectable collagen filler,in ... EVOLENCE(R) boasts immediate, predictable visible results, with little,swelling. ... EVOLENCE(R) in a,comparison study against a popular dermal ...
Cached Medicine News:Health News:Breast-Conserving Surgery Leaves Many Cancer Patients Disappointed 2Health News:Seniors Having More Sex Than Ever 2Health News:Seniors Having More Sex Than Ever 3Health News:Mesa Laboratories, Inc. Named to Fortune Small Business Magazine's 2008 List 2Health News:China Medicine Releases White Paper on Developing Recombinant Aflatoxin-Detoxifizyme 2Health News:Nyer Medical Group, Inc. Announces Sale of Company's Florida Medical-Surgical Division; Pharmacy Division Awarded Two-Year Preferred Supplier Contract 2Health News:Nyer Medical Group, Inc. Announces Sale of Company's Florida Medical-Surgical Division; Pharmacy Division Awarded Two-Year Preferred Supplier Contract 3Health News:New Injectable Collagen Filler Offers Natural Results 2
(Date:12/24/2014)... FLINT, Mich. , Dec. 24, 2014  Diplomat ... largest independent specialty pharmacy, is proud to announce ... and quality at Diplomat, will take office as the ... 2015. The formal induction ceremony will take place Feb. ... which will be held at the Renaissance Center in ...
(Date:12/24/2014)... , Dec. 23, 2014 PuraMed BioScience®, ... of over-the-counter (OTC) medicinal and healthcare products, announced it ... MigraPure® H, a hemp-based, advanced headache relief product, for ... in Colorado , Washington ... With the MigraPure H Advanced headache relief ...
(Date:12/24/2014)... -- ResMed (NYSE: RMD ) today announced its ... device manufacturer BMC Medical Co., Ltd. The ... below infringe ResMed,s patents, and entered an order prohibiting BMC ... the United States : , iVolve nasal ... nasal pillows mask , iVolve full face mask ...
Breaking Medicine Technology:Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2
... Risk Based on Clinical Data, ... WALTHAM, Mass., July 22 Interleukin Genetics,Inc. (Amex: ... an enhanced test report,format and information package for ... currently marketed under the brand name Gensona(R) Heart ...
... The SEAS (Simvastatin and Ezetimibe in,Aortic Stenosis) ... with the combination of simvastatin (40 mg daily) ... stenosis., Aortic stenosis (which involves partial blockage ... relatively common disease among older people in Western,populations. ...
Cached Medicine Technology:Interleukin Genetics Launches Enhanced Heart Health Genetic Test Report Format 2Interleukin Genetics Launches Enhanced Heart Health Genetic Test Report Format 3Results From the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) Study 2Results From the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) Study 3Results From the SEAS (Simvastatin and Ezetimibe in Aortic Stenosis) Study 4
Luria bertani broth: 1.0% Tryptone, 0.5% Yeast Extract, 1.0% Sodium Chloride....
2.5% Soytone, 4.8% Yeast Extract, 0.025% Magnesium Sulfate, 130mM Calcium Chloride....
... pH: pH(4.7%, H 2 O): 7.0 ... 47% Potassium Phosphate Dibasic: 25% Potassium Phosphate Monobasic: ... powder per liter of purified water. Autoclave. Application: ... proteins than LB media by allowing for greater ...
...
Medicine Products: