Navigation Links
Structure of key molecule in immune system provides clues for designing drugs
Date:12/27/2010

he complement protein C3 is enzymatically cleaved to form C3b, which binds to the surface of a target cell. C3b then binds factor B to produce C3bB. This complex, in turn, binds another enzyme, factor D (producing C3bBD), which cleaves the complex to form the active C3bBb. The major target of the active C3bBb is C3 itself, resulting in rapid amplification of the complement cascade.

To capture structural snapshots of C3bB and C3bBD, the researchers first generated mutant proteins that would stabilize the complexes in their active forms. Then, Lambris and Gros used x-ray crystallography to describe the two complexes in atomic detail. They found that, upon binding to C3b, factor B changes its shape to form an "open complex," which can then be bound by factor D. Factor D, in turn, shifts its shape in a more subtle yet no less important way: The free protein is inactive because a protein loop blocks the active site of the enzyme. Upon binding to C3bB, that loop alters its position, thereby activating factor D to cleave C3bB into the C3bBb complex.

These findings, Lambris said, provide molecular explanations for several safety features of the complement system. First, they explain why factor D is inactive on its own, but active when engaged by C3bB. They also illustrate a "double safety catch" mechanism the system uses to keep itself in check, preventing complement activation in the absence of a target.

Finally, and perhaps most importantly, they provide data that can aid the design of inhibitors against factor D, which may prove useful in the treatment of complement-associated diseases.

"Besides shedding light on a highly elegant mechanism of concerted activation and intrinsic regulation, this work also offers a detailed insight into one of the most important therapeutic targets within the complement network, which may facilitate rational drug development and could lead to novel drugs for treating complement-related diseases," Lamb
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Structure deep within the brain may contribute to a rich, varied social life
2. Gestational Period Depends on Structure of Placenta: Research
3. Growth factor regenerates tooth supporting structures: Results of a large randomized clinical trial
4. Structured Diet, Exercise Plans Seem to Shed Pounds
5. Study details structure of potential target for HIV and cancer drugs
6. Feeling Introspective? Your Brain Structure May Be Key
7. Edible nanostructures
8. Menstrual cramps may alter brain structure
9. Viral protein structure study offers HIV therapy hope
10. Cancers of sweat glands, other skin-related structures may be increasing in United States
11. System that predicts protein structures could help researchers design drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Structure of key molecule in immune system provides clues for designing drugs
(Date:4/21/2015)... The Northeast Football Clinic (NEFC) has trained ... school in Byfield, MA. Applications are being accepted for ... grades 6-12. , The outstanding professional, college, and high ... , Offensive and defensive linemen and linebackers ... most unsung positions on the field, the the success ...
(Date:4/21/2015)... 2015 Freeslate, Inc ., the ... today announced that the Centre for Catalysis Research ... has acquired a Freeslate Core Module 3 (CM3) ... (SPR) to accelerate current research programs. The systems ... they will be available to academic users and industrial ...
(Date:4/21/2015)... (PRWEB) April 21, 2015 This ... pathologists, physical therapist assistants, occupational therapist assistants, teachers, ... and techniques to help children across the autism ... through Education Resources Inc. , ... 2008, this highly acclaimed yoga curriculum addresses learning ...
(Date:4/20/2015)... Draft, Virginia (PRWEB) April 20, 2015 ... Augusta Health facility in Stuarts Draft, an independent, ... County, Staunton, and Waynesboro, Virginia. The project was ... Architects. The Stuarts Draft facility is expected to ... , Located on Stuarts Draft Highway, the new ...
(Date:4/20/2015)... April 21, 2015 The National ... Binau, Founder of Soul Care Group, Inc., as ... is recognized with this prestigious distinction for leadership in ... Local Chapters, NAPW is the nation's leading networking organizaiton ... Susan with our Woman of the Year Award,” says ...
Breaking Medicine News(10 mins):Health News:US Sports Camps and The Northeast Football Clinic Announce 2015 Lineman/Linebacker Clinic Schedule 2Health News:University of Ottawa Selects Freeslate Reaction Screening System to Support High-Throughput Research at the Centre for Catalysis Research and Innovation 2Health News:University of Ottawa Selects Freeslate Reaction Screening System to Support High-Throughput Research at the Centre for Catalysis Research and Innovation 3Health News:ABC News Interviews Anne Buckley-Reen, Education Resources Inc. Faculty Member, on Yoga Therapy in the Classroom 2Health News:Augusta Health Construction Wraps Up at Stuarts Draft 2Health News:National Association of Professional Women Announces Susan Binau, Founder of Soul Care Group, Inc., a 2015 Professional Woman of the Year 2
... Stabilized ... ENADH NADH, ... and distributor of nadh branded nutritional products, has,obtained the exclusive distribution ... the USA. ENADA,NADH was the original nadh product, stabilized by Prof. ...
... Breathing,Resistance Exerciser has been selected as the ... L.A. Times. Jorge Brouwer, inventor of the ... the easy,to use "Expand-A-Lung.", *(PHOTO ... Resistance Exerciser.) When asked about how ...
... Life Sciences,Inc. (TSX: BNC), a research-based, technology-driven Canadian,biopharmaceutical ... vaccine at the 6th Congress of Medical Microbiology ... presentation was made by Dr. Dragan,Rogan, Vice-President, Bioniche ... vaccine is the world,s first vaccine that may ...
... June 17 For women about to give,birth, one ... ensuring they have on,hand the right music., (Photo: ... studies have found that music can reduce,anxiety and stress ... "There,s a lot of pain and discomfort that can ...
... Research in the United States has shown that obese people ... for breast, colon and cervical cancer. Raj Padwal, Rebecca Mitchell ... Medicine & Dentistry, have undertaken a study to see if ... obesity is associated with higher rates of some types of ...
... ,lack of motivation, ,lack of money, and ,lack of time, as, ... ... health, SANTA MONICA, Calif., June 17 Findings from a ... to improve their overall health, but less than half of those ...
Cached Medicine News:Health News:ENADA NADH Is Back 2Health News:Have You Exercised Your Lungs Today? 2Health News:Bioniche Presents E. coli O157:H7 Vaccine Data to International Congress of Medical Microbiology in Serbia 2Health News:Bioniche Presents E. coli O157:H7 Vaccine Data to International Congress of Medical Microbiology in Serbia 3Health News:Using Music to Ease the Pain of Labor; New CD Featuring Celine Dion, Norah Jones, Provides Soothing Songs for Delivery 2Health News:Obese women in Canada are less likely to be screened for cervical cancer 2Health News:LIVESTRONG.COM Survey Reveals 86 Percent of Americans Attempt Changes to Improve Their Health but Less Than Half are Successful 2Health News:LIVESTRONG.COM Survey Reveals 86 Percent of Americans Attempt Changes to Improve Their Health but Less Than Half are Successful 3Health News:LIVESTRONG.COM Survey Reveals 86 Percent of Americans Attempt Changes to Improve Their Health but Less Than Half are Successful 4
(Date:4/20/2015)... April 20, 2015 This report analyzes the ... US$ Million. The report provides separate comprehensive analytics for ... Europe , and Rest of World. Annual estimates ... 2020. Also, a seven-year historic analysis is provided for ... primary and secondary research. Company profiles are primarily based ...
(Date:4/20/2015)...  Sigma-Aldrich Corporation (Nasdaq: SIAL ) was ... of the 100 Best Corporate Citizens, which ranks ... Sigma-Aldrich ranked fifth, its highest ranking to date, ... "We are honored to be recognized once ... are extremely pleased with our ranking," said ...
(Date:4/20/2015)... , April 20, 2015   Spirox ... today the closing of an $18.5 million Series B round ... Existing investors Aperture Venture Partners, Correlation Ventures and ... Spirox, which is developing a novel, minimally invasive ... Throat (ENT) physicians and plastic surgeons to treat ...
Breaking Medicine Technology:World Medical Equipment Rental and Leasing Industry 2World Medical Equipment Rental and Leasing Industry 3World Medical Equipment Rental and Leasing Industry 4World Medical Equipment Rental and Leasing Industry 5World Medical Equipment Rental and Leasing Industry 6World Medical Equipment Rental and Leasing Industry 7Sigma-Aldrich Named to CR Magazine's 100 Best Corporate Citizens List 2Spirox, Inc. Announces Closing of $18.5MM Series B Financing 2Spirox, Inc. Announces Closing of $18.5MM Series B Financing 3
... , , SOLNA, Sweden , ... Exchange: AERO) today announced that a group of prominent clinicians ... the US, has issued a consensus paper recommending that inflammation ... routine clinical management of asthma in conjunction with other conventional ...
... to develop automated system to better control diabetes represents first ... YORK , Jan. 13 The Juvenile Diabetes ... to develop an automated system to help people with type ... on the path to what would be among the most ...
Cached Medicine Technology:US Expert Panel Recommends the Use of Fractional Exhaled Nitric Oxide (FENO) in the Diagnosis and Management of Asthma 2US Expert Panel Recommends the Use of Fractional Exhaled Nitric Oxide (FENO) in the Diagnosis and Management of Asthma 3US Expert Panel Recommends the Use of Fractional Exhaled Nitric Oxide (FENO) in the Diagnosis and Management of Asthma 4JDRF Forms Partnership With Animas to Develop First-Generation Automated System for Managing Type 1 Diabetes 2JDRF Forms Partnership With Animas to Develop First-Generation Automated System for Managing Type 1 Diabetes 3JDRF Forms Partnership With Animas to Develop First-Generation Automated System for Managing Type 1 Diabetes 4JDRF Forms Partnership With Animas to Develop First-Generation Automated System for Managing Type 1 Diabetes 5
Turnstile casting stand for easy and safe casting. The compact system sets up quickly and stores conveniently, and the non-stick coating prevents fiberglass or plaster from adhering to surface....
Bone cement with Gentamicin 2.5%....
... Techno-Aide provides the highest level of ... quality lead protective eyewear. Consistent ... tolerance allowed. Mfg supervised by Licensed ... lens meet or exceed standards for ...
... Comfort fit large designer ... adjustable strap bridge providing a ... on the nose. The head ... for custom fit. The acrylic ...
Medicine Products: