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Structure of inner-ear protein is key to both hearing and inherited deafness
Date:4/16/2010

"and were able to obtain the structure of the mutated protein. With simulations, we could test both structures' elasticity and reactions to force."

The researchers found that some mutations reduced the ability of the protein to bind calcium ions. Simulations showed this change ultimately weakened the protein. In addition, simulations revealed that other deafness-causing mutations exhausted the ability of calcium to hold cadherin-23 together.

These findings, the researchers believe, offer insight that may one day better inform efforts to develop therapeutic interventions.


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Contact: David Cameron
david_cameron@hms.harvard.edu
716-432-0441
Harvard Medical School
Source:Eurekalert

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