Navigation Links
Structure of inner-ear protein is key to both hearing and inherited deafness
Date:4/16/2010

deafness are mutations specifically to the amino acids that bind the calcium. And these findings show how critical calcium ions, and the amino acid residues that bind them, are to the structure of this protein."

The research will appeared in the April 15 issue of Neuron.

To get an atomic-level view of how cadherin-23 behaves under normaland abnormalconditions, the scientists used a combination of protein crystallization and virtual-reality-like simulation that showed how the cadherin could break in billionths of a second.

Through crystallization, the researchers found that, like other members of the cadherin family, this protein contains three critical calcium ions between each of its 27 bead-like segments. The simulations showed that the ions formed a strong link between adjacent beads, sufficient to hold them together. In addition, a novel calcium-ion binding site was discovered at the very end of cadherin-23.

According to Corey, these binding sites "staple" the various subunits of cadherin-23 together and may also create the bond made with the second protein of the tip link.

To quantify exactly how strong these calcium-ion bonds were, the scientists loaded the protein's structure into a supercomputer, rendered its virtual likeness, then "stretched" the structure. They found that overall the protein acted more like a wire cable than a spring, as previously thought. This made it capable of withstanding forces ten-fold stronger than any that might be produced by normal sounds. When the scientists tested the structure against very great forces, however, it unraveled.

The researchers then elected to test how mutations similar to those associated with inherited deafness might alter cadherin-23's structure and affinity for calcium ions.

"We had the three-dimensional structure of the wild type protein," says Marcos Sotomayor, an HMS research fellow in neurobiology and co-lead author on the study,
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
716-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Developing a cyberinfrastructure for comparative effectiveness in cancer research
2. 3-D scaffold provides clean, biodegradable structure for stem cell growth
3. A Finnish-Swiss team cracks the atomic structure of a major cancer drug target
4. Scripps Research scientists reveal key structure from ebola virus
5. DiagnoCure announces optimization of entreprise structure
6. Scientists find donut-shaped structure of enzyme involved in energy metabolism
7. Aerohive Positioned in the “Visionaries” Quadrant of the Magic Quadrant for Wireless LAN Infrastructure
8. ATS, ERS issue official standards for the quantitative assessment of lung structure
9. Aspirus Eases Pain of Rapid Data Growth With an EMC Information Infrastructure
10. Jusuru—Just Launched—Expands Its Infrastructure to Keep Up With Skyrocketing Sales
11. Lakeside Medical Group, Heritage Provider Network, CEO Dr. Richard Merkin, Featured on Several Segments of Fox National News and Fox Business Channel on Current Healthcare Payment Structures to Physicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... 22, 2014 Recently, UWDress.com is gratified ... guest dresses . In addition, the company has also ... , As a leading online supplier of wedding dresses, ... outfits. The unusual best wedding guest gowns are provided ... amazing designs, this new selection is famous for high ...
(Date:11/22/2014)... Sandbridge Capital, a private equity firm ... brand sector, acquired a minority stake in BackJoy ... help fund BackJoy’s global growth and accelerate the ... apparel and footwear lines. Sandbridge Capital Managing Partner ... , BackJoy is a high-growth health and wellness ...
(Date:11/22/2014)... 2014 “Greenfield Naturals” was featured on ... , which features the latest and coolest technology products ... reporter for NewsWatch, conducted the product review and shared ... of your water. , From pollution to hazardous substances ... everything is done to remove these chemicals, especially in ...
(Date:11/22/2014)... -- A clinical trial of hydroxyurea therapy for children ... early because the results show it is a safe ... the risk of stroke. The announcement about the ... the United States and Canada, was made this week ... (NHLBI). Researchers compared monthly blood transfusions with daily ...
(Date:11/22/2014)... HealthDay Reporter FRIDAY, Nov. ... patients are treated in an ambulance by a neurologist equipped ... The sooner patients get the clot dissolver -- tissue ... stroke, the researchers noted. For the best outcome, the drug ... symptoms start, the researchers said. "The so-called ,golden hour, ...
Breaking Medicine News(10 mins):Health News:Best Wedding Guest dresses Introduced by UWDress.com 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 3Health News:An Easy Home Solution to Get Better Tasting Water was Featured on NewsWatch Television on October 30, 2014 2Health News:Sickle Cell Anemia Treatment So Successful in Kids That Trial Is Halted 2Health News:Special Ambulance Delivers Vital Stroke Care More Quickly 2Health News:Special Ambulance Delivers Vital Stroke Care More Quickly 3
... April 30 New data is showing a ... children in this country.,Here,s more on one group,s ... Listen to this report from Safe Kids Worldwide ... video, audio, text, graphics and,photos for free and ...
... eligible Medicaid members, PHOENIX, April 30 ... law, allowing the state Medicaid program to,expend moneys ... Introduced by Sen. Barbara Leff (R-Paradise Valley), ... state,s General Fund and will provide benefits,for nicotine ...
... in relapsing remitting illness , , WEDNESDAY, April 30 (HealthDay ... people with the relapsing remitting form of multiple sclerosis ... the disease were randomly selected to receive either 20 ... for 24 weeks. MRI brain scans were conducted every ...
... Cadence Pharmaceuticals,Inc. (Nasdaq: CADX ), a biopharmaceutical ... candidates principally,for use in the hospital setting, today ... results before the market opens on Tuesday, May ... call and live webcast to,discuss the financial results ...
... to Both Reduce Exacerbations ... and Improve Lung Function, ... and Drug Administration today approved Advair Diskus(R) 250/50,(fluticasone propionate 250 ... exacerbations in patients with chronic obstructive,pulmonary disease (COPD) who have ...
... Activity in Child Care Focuses on Child Care Providers, Perspectives; Cincinnati, ... ... Annual Meeting, CINCINNATI, April 30 At a time when ... growing concern over,childhood obesity has led physicians to focus on whether children ...
Cached Medicine News:Health News:Governor Napolitano Signs Smoking Cessation Bill 2Health News:Prozac Reduces Disease Activity in MS Patients 2Health News:Cadence Pharmaceuticals to Host Conference Call and Webcast to Discuss First Quarter Financial Results and Provide a Clinical Program Update on May 6, 2008 2Health News:FDA Approves Advair(R) 250/50 for Reduction of Exacerbations in Patients With COPD 2Health News:FDA Approves Advair(R) 250/50 for Reduction of Exacerbations in Patients With COPD 3Health News:FDA Approves Advair(R) 250/50 for Reduction of Exacerbations in Patients With COPD 4Health News:Flip Flops, Mulch and No Coat: Study Identifies Surprising Barriers to Outdoor Activity for Kids in Child-Care Centers 2Health News:Flip Flops, Mulch and No Coat: Study Identifies Surprising Barriers to Outdoor Activity for Kids in Child-Care Centers 3Health News:Flip Flops, Mulch and No Coat: Study Identifies Surprising Barriers to Outdoor Activity for Kids in Child-Care Centers 4
(Date:11/22/2014)... 2014 Research and Markets  has announced the ... Report, 2014-2017" report to their offering. ... recombinant protein drug market has been expanding rapidly owing ... the like. During 2005-2013, sales of recombinant protein drugs ... of 19.1%, and it is projected that ...
(Date:11/21/2014)... SAN DIEGO , Nov. 21, 2014 /PRNewswire/ ... TNDM ), a medical device company and ... today announced a partnership with Tidepool, a non-profit ... an open source software platform that increases diabetes ... the Tidepool Platform, which is currently under development, ...
(Date:11/21/2014)... , Nov. 21, 2014  Abaxis, Inc. (NasdaqGS: ... point-of-care instruments and consumables for the medical, research, and ... the veterinary and research markets in the ... a stock purchase agreement to acquire 100% of QCR ... based distribution organization. The transaction closed on ...
Breaking Medicine Technology:China Recombinant Protein Drug Industry Report, 2014-2017 2China Recombinant Protein Drug Industry Report, 2014-2017 3Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3Abaxis Acquires UK-based Distribution Organization 2Abaxis Acquires UK-based Distribution Organization 3Abaxis Acquires UK-based Distribution Organization 4
... Inc.,(NYSE:MDT) today announced that a review of ... that the trial has met its primary,non-inferiority ... a randomized, single-blind,trial evaluating the safety and ... as compared to the TAXUS Paclitaxel-Eluting,Coronary Stent ...
... Cardiovascular Target from Lexicon's Genetic,Research -, ... /PRNewswire-FirstCall/ --,Lexicon Pharmaceuticals, Inc. today reported ... directed to a,potential new target, angiopoietin-like ... cholesterol. Research suggests that,a monoclonal antibody ...
Cached Medicine Technology:ENDEAVOR IV Clinical Trial Meets Primary Endpoint 2Lexicon Develops Antibodies That Lower Triglycerides and,Cholesterol as Potential New Therapy for Heart Disease 2Lexicon Develops Antibodies That Lower Triglycerides and,Cholesterol as Potential New Therapy for Heart Disease 3Lexicon Develops Antibodies That Lower Triglycerides and,Cholesterol as Potential New Therapy for Heart Disease 4Lexicon Develops Antibodies That Lower Triglycerides and,Cholesterol as Potential New Therapy for Heart Disease 5
Non-dissolvable Herrick Lacrimal Plugs provide long-term lacrimal occlusion through partial blockage of the horizontal canaliculus....
Provides quick freezing and quick defrosting. Lightweight probe tips have high conductivity silver. Useful for Cataract, Retinal Detachment, Glaucoma and Intra-vitreal surgery. Includes either one ca...
Khosla Precision and Quality in Medical and Surgical Products....
Khosla Precision and Quality in Medical and Surgical Products....
Medicine Products: