Navigation Links
Structure of inner-ear protein is key to both hearing and inherited deafness
Date:4/16/2010

deafness are mutations specifically to the amino acids that bind the calcium. And these findings show how critical calcium ions, and the amino acid residues that bind them, are to the structure of this protein."

The research will appeared in the April 15 issue of Neuron.

To get an atomic-level view of how cadherin-23 behaves under normaland abnormalconditions, the scientists used a combination of protein crystallization and virtual-reality-like simulation that showed how the cadherin could break in billionths of a second.

Through crystallization, the researchers found that, like other members of the cadherin family, this protein contains three critical calcium ions between each of its 27 bead-like segments. The simulations showed that the ions formed a strong link between adjacent beads, sufficient to hold them together. In addition, a novel calcium-ion binding site was discovered at the very end of cadherin-23.

According to Corey, these binding sites "staple" the various subunits of cadherin-23 together and may also create the bond made with the second protein of the tip link.

To quantify exactly how strong these calcium-ion bonds were, the scientists loaded the protein's structure into a supercomputer, rendered its virtual likeness, then "stretched" the structure. They found that overall the protein acted more like a wire cable than a spring, as previously thought. This made it capable of withstanding forces ten-fold stronger than any that might be produced by normal sounds. When the scientists tested the structure against very great forces, however, it unraveled.

The researchers then elected to test how mutations similar to those associated with inherited deafness might alter cadherin-23's structure and affinity for calcium ions.

"We had the three-dimensional structure of the wild type protein," says Marcos Sotomayor, an HMS research fellow in neurobiology and co-lead author on the study,
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
716-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Developing a cyberinfrastructure for comparative effectiveness in cancer research
2. 3-D scaffold provides clean, biodegradable structure for stem cell growth
3. A Finnish-Swiss team cracks the atomic structure of a major cancer drug target
4. Scripps Research scientists reveal key structure from ebola virus
5. DiagnoCure announces optimization of entreprise structure
6. Scientists find donut-shaped structure of enzyme involved in energy metabolism
7. Aerohive Positioned in the “Visionaries” Quadrant of the Magic Quadrant for Wireless LAN Infrastructure
8. ATS, ERS issue official standards for the quantitative assessment of lung structure
9. Aspirus Eases Pain of Rapid Data Growth With an EMC Information Infrastructure
10. Jusuru—Just Launched—Expands Its Infrastructure to Keep Up With Skyrocketing Sales
11. Lakeside Medical Group, Heritage Provider Network, CEO Dr. Richard Merkin, Featured on Several Segments of Fox National News and Fox Business Channel on Current Healthcare Payment Structures to Physicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... 2014 Physical fitness may buffer some of the adverse ... new study by researchers from the American Cancer Society, ... study appears in the journal Mayo Clinic Proceeding ... and obesity and blood markers associated with cardiovascular disease ... , Sedentary behavior has been linked to an increase ...
(Date:7/14/2014)... July 14, 2014 BCC Research ... SYNTHETIC BIOLOGY: GLOBAL MARKETS , the global ... nearly $11.9 billion in 2018, with a five-year ... products account for the fastest growing segment, with ... Synthetic biology-enabled products in the pharmaceutical/diagnostics, chemical, energy, ...
(Date:7/14/2014)... CA (PRWEB) July 14, 2014 The ... Group is now offering Lumineers and porcelain ... extensive procedures that require more preparation and greater loss ... porcelain tooth-shaped shells to conceal visible flaws on the ... Sabbagh-Fard work closely with patients to ensure they offer ...
(Date:7/14/2014)... Bronson Gray HealthDay Reporter ... research suggests that a faltering sense of smell might ... an inexpensive, low-tech smell test could spot who needs ... studies, the decreased ability to identify odors was associated ... to Alzheimer,s disease. "We,re trying to be able ...
(Date:7/14/2014)... HealthDay Reporter MONDAY, July 14, 2014 (HealthDay ... health issues, but dementia isn,t one of them, according to ... delay dementia, the researchers found. "For those who had ... a later age of developing full-blown dementia compared to those ... Woodruff, an assistant professor of neurology at the Mayo ...
Breaking Medicine News(10 mins):Health News:Physical fitness associated with less pronounced effect of sedentary behavior 2Health News:Global Market for Synthetic Biology to Reach Nearly $11.9 Billion by 2018 — Enabled Products Account for the Fastest Growing Segment with 36.7% CAGR 2Health News:Global Market for Synthetic Biology to Reach Nearly $11.9 Billion by 2018 — Enabled Products Account for the Fastest Growing Segment with 36.7% CAGR 3Health News:Encino Esthetic Dental Group is Now Offering Lumineers and Porcelain Veneers 2Health News:Could a Simple Smell Test Help Spot Alzheimer's Early? 2Health News:Could a Simple Smell Test Help Spot Alzheimer's Early? 3Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 2Health News:Widowhood May Delay Dementia in Some Seniors, Study Finds 3
... of gift-,givers, Valentine,s Day never fails to leave some people ... feel truly special. Of,course roses are the go-to gift that,s ... a new HD TV the best way to tell him, ... reason why gift certificates sales were,second only to clothing during ...
... the International Society for Cardiovascular Translational Research (ISCTR) ... the Journal of Cardiovascular Translational Research (JCTR). ... Inaugural Meeting of the International Society for Cardiovascular ... 2008 in San Diego, CA, USA. The ...
... Features Over 7,400 Furniture Products & Services, ... VWR International, LLC, a,global distributor of scientific ... new 2008-2010 Laboratory Casework and Technical,Furniture Catalog, ... for the research laboratory industry, including customers ...
... living near the World Trade Center had sleeplessness, other ... -- Direct exposure to the World Trade Center ... shows. , The study, by researchers at the Mount ... 116 children averaging about 4 years of age who ...
... Merrill Lynch,s Global Pharmaceutical Conference Feb. ... 5, 2008, ... it will host a conference call and live webcast on,Wednesday, Feb. 27, 2008, ... ended Dec. 31, 2007. The Company also will provide,an operational and integration update ...
... Coherent, Inc.,(Pink Sheets: COHR), today announced its slate ... proxy for the annual meeting scheduled for,March 19, 2008 ... The nominees include current directors Garry Rogerson, John,Ambroseo, John ... first-time,nominees Susan James and Clifford Press., Susan James ...
Cached Medicine News:Health News:Leading Network of Aesthetic Service Providers Offers Unique Gift Ideas for Valentine's Day 2Health News:Springer to publish new society journal in cardiology 2Health News:VWR International Publishes New Laboratory Casework and Technical Furniture Catalog 2Health News:VWR International Publishes New Laboratory Casework and Technical Furniture Catalog 3Health News:9/11 Exposure Linked to Behavior Trouble in Kids 2Health News:Mylan Schedules Financial Results Conference Call and Live Webcast for the Quarter and Nine Months Ended Dec. 31, 2007 2Health News:Coherent Announces Director Slate for Upcoming Annual Meeting 2
(Date:7/14/2014)... 2014  Mylan Inc. (NASDAQ: MYL ) today ... Abbott (NYSE: ABT ) ... developed markets specialty and branded generics business ("the Assets") in ... will receive 105 million shares of the combined company worth ... on Friday, July 11, 2014, representing an approximately 21% ownership ...
(Date:7/11/2014)... CHAPEL HILL, N.C. , July 11, 2014 ... component of pharmaceutical marketing and, consequently, organizations are ... specifically for patients. As part of ... learned it,s important to educate, communicate and engage ... from disease awareness to patient empowerment. By mapping ...
(Date:7/11/2014)... July 11, 2014 Research and Markets ... Needles Market 2014-2018" report to their offering. ... hypodermic needle is a hollow needle commonly used with ... or to extract fluids from it. A hypodermic needle ... inject substances that cannot be ingested. Hypodermic needles are ...
Breaking Medicine Technology:Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 2Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 3Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 4Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 5Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 6Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 7Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 8Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 9Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 10Mylan To Acquire Abbott's Non-U.S. Developed Markets Specialty And Branded Generics Business In An All-Stock Transaction 11New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3
... Md., May 24, 2007 /PRNewswire-FirstCall/ -- Iomai,Corporation today ... 1 trial of its patch-based needle-free influenza vaccine,before ... live,webcast will be held at 8:30 a.m. Eastern ... Details , To access the live conference call ...
... Texas--(BUSINESS WIRE)--May 29, 2007 - Introgen,Therapeutics, Inc. ... updated Phase 2 clinical trial results,for its ... upcoming,annual meetings of The American Society of ... Society of Gene Therapy (ASGT) in,Seattle., "We ...
Cached Medicine Technology:Iomai to Announce Results From Phase 1 Influenza Trial and Host,Webcast Tomorrow 2Introgen and Clinical Collaborators to Report New Results with,Advanced-Stage Cancer Therapies at Upcoming Medical Meetings 2Introgen and Clinical Collaborators to Report New Results with,Advanced-Stage Cancer Therapies at Upcoming Medical Meetings 3
Disposable Microscissors: Horizontal, Curved...
Disposable Microscissors: Horizontal, Straight...
Disposable Microscissors: Vertical, 90...
Low profile, sharp-tipped scissors with a vertical cutting action. Excellent for peeling and cutting fine epiretinal membranes....
Medicine Products: