Navigation Links
Structure of inner-ear protein is key to both hearing and inherited deafness
Date:4/16/2010

(Boston, Mass., April 14, 2010) Rising from the top surface of each of the specialized receptor cells in our inner ears is a bundle of sensory cilia that responds to the movement of sound. As sensitive as they are fragile, these cilia can move to wisps of sound no larger than a moleculebut can shear at sounds that are larger than life.

Cilia function mechanically, fluttering back and forth in response to sound vibrations. The tug of the cilia creates tension in fine "tip links" that tether each cilium to its neighbor, causing them to pull open channels that allow ions to flow into the receptor cells. This ion movement into the receptor cells, called hair cells for their microscopic bundles of cilia, generates the electrical signals that go to the brain to be translated into the sound of, say, footsteps, or a sonata, or a helicopter landing.

The ciliatip link apparatus in the hair cell is a clever arrangement of spring-like and string-like protein molecules, yet their atomic structures and mechanical properties are not well known.

Now new work from the laboratories of David Corey, professor of neurobiology at Harvard Medical School and Howard Hughes Medical Institute investigator, and Rachelle Gaudet, associate professor of molecular and cellular biology at Harvard University's Faculty of Arts and Sciences, has discovered how the structure of a vital region of cadherin-23, one of two proteins that join to form each tip link, relates to the hearing process. Researchers found cadherin-23 to be stronger and stiffer than previously thought, a characteristic produced by calcium ions that bind within folds of the protein and tie the folds together. Furthermore, they found that many mutations to cadherin-23 cause inherited deafness by weakening the ability of calcium to hold the protein together.

"Our findings help explain a whole class of inherited deafness," says Corey. "Many, many different mutations that cause inherited
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
716-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Developing a cyberinfrastructure for comparative effectiveness in cancer research
2. 3-D scaffold provides clean, biodegradable structure for stem cell growth
3. A Finnish-Swiss team cracks the atomic structure of a major cancer drug target
4. Scripps Research scientists reveal key structure from ebola virus
5. DiagnoCure announces optimization of entreprise structure
6. Scientists find donut-shaped structure of enzyme involved in energy metabolism
7. Aerohive Positioned in the “Visionaries” Quadrant of the Magic Quadrant for Wireless LAN Infrastructure
8. ATS, ERS issue official standards for the quantitative assessment of lung structure
9. Aspirus Eases Pain of Rapid Data Growth With an EMC Information Infrastructure
10. Jusuru—Just Launched—Expands Its Infrastructure to Keep Up With Skyrocketing Sales
11. Lakeside Medical Group, Heritage Provider Network, CEO Dr. Richard Merkin, Featured on Several Segments of Fox National News and Fox Business Channel on Current Healthcare Payment Structures to Physicians
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... 14, 2014 Sometimes, thinking “inside the ... Playground announces its first product release, Joyboxx™ - The ... system. , Inventor and CEO, Deborah Semer ... have a storage solution for their ‘toys’ after she ... adult retail industry. , Semer met 30-year industry veteran ...
(Date:7/14/2014)... July 14, 2014 The Cabin Chiang ... its new Alumni Community website – a ... to help them maintain lifelong recovery wherever they live ... providing clients the tools to help them maintain their ... essential part of any reputable treatment programme. As a ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 AttorneyOne.com, a ... all the latest information from the FDA on ... The FDA informed on July 11, that one lot ... mL, Flexible Container, by Hospira Inc., is recalled due ... parenteral replacement of extracellular losses of fluid and electrolytes, ...
(Date:7/14/2014)... According to the Blood Pressure Solution book review recently updated ... series of new information on high blood pressure . ... help readers understand more about blood pressure. The book shows ... to control hypertension naturally. , Blood Pressure ... by Ken Burge, a medical researcher and health consultant. Since ...
(Date:7/14/2014)... to the Boost Your Bust book review recently updated by Vkool.com, ... how to increase the size of their breasts naturally without medication ... , Chapter 1 – What Are Your Breasts And ... Natural Breast Enlargement Works , Chapter 3 – The ... 4 – The Groundwork , Chapter 5 – Personal ...
Breaking Medicine News(10 mins):Health News:Passionate Playground launches Joyboxx 2Health News:Passionate Playground launches Joyboxx 3Health News:The Cabin Chiang Mai Addiction Rehab Launches Industry-leading Aftercare Service 2Health News:The Cabin Chiang Mai Addiction Rehab Launches Industry-leading Aftercare Service 3Health News:Hospira Lactated Ringer’s and 5% Dextrose Injection Recalled: AttorneyOne Monitor and Keep Consumers Informed 2Health News:Hospira Lactated Ringer’s and 5% Dextrose Injection Recalled: AttorneyOne Monitor and Keep Consumers Informed 3Health News:Blood Pressure Solution Book Review Exposes Ken Burge's Hypertension Treatment Guide – Vkool.com 2Health News:Blood Pressure Solution Book Review Exposes Ken Burge's Hypertension Treatment Guide – Vkool.com 3Health News:Boost Your Bust Book Review Exposes Jenny Bolton's Breast Enhancement Guide – Vkool.com 2Health News:Boost Your Bust Book Review Exposes Jenny Bolton's Breast Enhancement Guide – Vkool.com 3
... research published in The Lancet states that, consuming a ... faster information processing and memory in the older adults. ... reduced levels of folate, and elevated levels of amino ... restricts cognitive ability, increasing the risk of dementia. ...
... the NHS trust to cater to mental problems afflicting the ... a document enabled by Durham County Council's inquiry committee, recognized ... in Durham and Darlington. The report threw light on the ... problems across six primary care trust areas in the region. ...
... the sake of good health., Students of Pittsburgh’s Plum ... last 10 months; via cafeteria meals. This was announced Thursday. ... by-products such as hulls of oats, soybeans, peas and rice, ... school meals to cut down calories while preserving a favorable ...
... showed reasonable resistance to Tamiflu, an antiviral, in two Egyptians who ... the medical community. ,The report also states that the ... in 2005. The occurrence of this strain in Egypt reveals that ... Tamiflu by the birdflu virus has not changed the WHO stance ...
... for short-term relief of chronic back pain, but their ... by researchers at Yale School of Medicine, who also ... in 24 percent of cases. ,“Patients with ... medications are used despite the concerns clinicians have with ...
... molecule that is part of a complex signaling network ... periventricular heterotopia (PVH), a congenital brain malformation, Yale School ... often leads to a variety of neurological disorders such ... It has many environmental and genetic causes, but is ...
Cached Medicine News:Health News:Long-Term Narcotics Use for Back Pain May Be Ineffective and Lead to Abuse 2Health News:Missing Molecule Has Important Role in a Developmental Brain Abnormality 2
(Date:7/11/2014)... , July 11, 2014 Research and ... Hypodermic Needles Market 2014-2018" report to their offering. ... A hypodermic needle is a hollow needle commonly used ... or or to extract fluids from it. A hypodermic ... to inject substances that cannot be ingested. Hypodermic needles ...
(Date:7/11/2014)... New York , July 11, 2014 ... by Transparency Market Research "Endoscopy Devices Market (Endoscopes, Endoscopic ... Size, Share, Growth, Trends and Forecast, 2013-2019" the global ... in 2012 and is expected to grow at a ... an estimated value of USD 36.9 billion in 2019. ...
(Date:7/11/2014)... -- Neurelis, Inc. ("Neurelis") today announced an agreement with ... by Biotie to purchase Neurelis, clearing the way for ... for pediatric and adult epilepsy patients who experience acute ... has advanced the development program for NRL-1 and worked ... required for NDA submission to the FDA.  Given the ...
Breaking Medicine Technology:Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Neurelis Regains Rights to Intranasal Diazepam Program 2Neurelis Regains Rights to Intranasal Diazepam Program 3
M2 cemented hip stem....
Porous foundation 480 series....
Cemented foundation 460 series....
Porous foundation 440 series....
Medicine Products: