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Structural Genomics Project creates blueprint for infectious disease and biodefense research
Date:9/1/2011

Sept. 1, 2011, SEATTLE The September issue of the online scientific journal Acta Crystallographica: Structural Biology and Crystallization Communications (Acta Cryst F) will consist entirely of work done at the Seattle Structural Genomics Center for Infectious Disease (SSGCID), a consortium of researchers from Seattle BioMed, Emerald BioStructures, the University of Washington and Pacific Northwest National Laboratory (PNNL). This free online edition (found at http://journals.iucr.org/f/issues/2011/09/00/issconts.html) features 30 peer-reviewed manuscripts, describing 40 unique infectious disease protein structures, as well as high-throughput gene-to-structure methodologies developed by SSGCID, and marks only the second time that Acta Cryst F has dedicated an entire issue to a single Structural Genomics center. The elucidation of such a large number of protein structures, all of which are freely available to scientific researchers to study and compare, provides a highly detailed "blueprint" for fighting infectious disease and bioterrorism.

Funded in late 2007 by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), to determine the three-dimensional structures of proteins from biodefense organisms and emerging infectious diseases, the SSCGID is directed by Dr. Peter Myler, a Full Member at Seattle BioMed and principal investigator of the project. "Currently the SSCGID has solved more than 375 protein structures from pathogenic microbes, providing much-needed new knowledge that serves as a starting point for structure-based drug design," said Myler. Many SSGCID structures also contain information on how small molecules bind to infectious disease proteins, providing highly valuable information for a drug discovery and development. Lance Stewart, CEO of Emerald BioStructures and co-principal investigator of the SSGCID project, commented "We've worked together to create an environment that
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Contact: Jennifer Mortensen
jennifer.mortensen@seattlebiomed.org
206-256-7220
Seattle Biomedical Research Institute
Source:Eurekalert

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