Navigation Links
Stronger intestinal barrier may prevent cancer in the rest of the body, new study suggests
Date:2/21/2012

PHILADELPHIA A leaky gut may be the root of some cancers forming in the rest of the body, a new study published online Feb. 21 in PLoS ONE by Thomas Jefferson University researchers suggests.

It appears that the hormone receptor guanylyl cyclase C (GC-C)a previously identified tumor suppressor that exists in the intestinal tractplays a key role in strengthening the body's intestinal barrier, which helps separate the gut world from the rest of the body, and possibly keeps cancer at bay. Without the receptor, that barrier weakens.

A team led by Scott Waldman, M.D., Ph.D., chair of the Department of Pharmacology and Experimental Therapeutics at Jefferson and director of the Gastrointestinal Cancer Program at Jefferson's Kimmel Cancer Center, discovered in a pre-clinical study that silencing GC-C in mice compromised the integrity of the intestinal barrier. It allowed inflammation to occur and cancer-causing agents to seep out into the body, damaging DNA and forming cancer outside the intestine, including in the liver, lung and lymph nodes.

Conversely, stimulating GC-C in intestines in mice strengthened the intestinal barrier opposing these pathological changes.

A weakened intestinal barrier has been linked to many diseases, like inflammatory bowel disease, asthma and food allergies, but this study provides fresh evidence that GC-C plays a role in the integrity of the intestine. Strengthening it, the team says, could potentially protect people against inflammation and cancer in the rest of the body.

"If the intestinal barrier breaks down, it becomes a portal for stuff in the outside world to leak into the inside world," said Dr. Waldman. "When these worlds collide, it can cause many diseases, like inflammation and cancer."

The role of
'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert  

0

GOOD

Page: 1 2

Related medicine news :

1. Healthier Diet, Stronger Sperm?
2. Women have stronger immune systems than men and its all down to a single chromosome
3. Stronger tobacco control policy in the Netherlands would save thousands of lives
4. College Football Players Get Bigger, Stronger With Age
5. Stronger social safety net leads to decrease in stress, childhood obesity
6. ACSM: Stronger hips improved running mechanics, lessened knee pain
7. Early Puberty Onset Linked to Stronger Bones
8. Parents Have Stronger Relationship When Dad Plays With Kids
9. Teens Breast-fed as Infants Have Stronger Leg Muscles
10. Sleep makes your memories stronger
11. Benefits of healthy lifestyle factors stronger in combination
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stronger intestinal barrier may prevent cancer in the rest of the body, new study suggests
(Date:5/20/2013)... MONDAY, May 20 (HealthDay News) -- Dermatologists are ... sunscreens should help Americans make smarter choices when ... sun protection. The new labels required by ... provide information about whether a sunscreen will protect ... will also have to indicate whether a sunscreen ...
(Date:5/20/2013)... A new Canadian study has uncovered an apparent gender ... than men to get trauma center care following a ... care services in general have been recognized for some ... to the treatment of severe injuries in trauma centers," ... Health Sciences Centre and the University of Toronto, said ...
(Date:5/20/2013)... Rapid Financial Services, LLC (dba RapidAdvance), one ... to small businesses, today announced the debut of its ... 20, the objective of RapidAdvance’s ‘Your Money’s Here’ campaign ... medium and through memorable executions that succinctly convey the ... company. By extension, the advertisements support RapidAdvance’s efforts ...
(Date:5/20/2013)... VHA Inc., the national health ... provider-led population health improvement, announced a new offering ... successfully pursue population health management with a ... accelerate the transition to value-based models of care. ... suite of services, the offering integrates VHA expert ...
(Date:5/20/2013)... 20, 2013 The International Distance Skateboard Association ... location for the best long distance skaters to attend and ... Lucie a venue of raising money for our local Boys ... The IDSA is the authority on long distance races throughout ... our event is safe and organized for all who want ...
Breaking Medicine News(10 mins):Health News:Revised Sunscreen Labels Should Help Consumers Make Wiser Choices 2Health News:Women Less Likely to Get Trauma Center Care After Injury: Study 2Health News:RapidAdvance Turns to National Television Advertising Campaign to Reach Small Business Owners 2Health News:RapidAdvance Turns to National Television Advertising Campaign to Reach Small Business Owners 3Health News:VHA Partners with Phytel to Add Population Health Management Services to the VHA IMPERATIVTM Performance Improvement Suite of Offerings 2Health News:VHA Partners with Phytel to Add Population Health Management Services to the VHA IMPERATIVTM Performance Improvement Suite of Offerings 3Health News:VHA Partners with Phytel to Add Population Health Management Services to the VHA IMPERATIVTM Performance Improvement Suite of Offerings 4
... China is no cause for alarm , , MONDAY, April ... case of human-to-human transmission of bird flu in China. ... there,s a genetic component to human-to-human transmission of this ... suggests that there,s some genetic component to resistance in ...
... powder-free, ANAHEIM, Calif., April 7, 2008 ... year,s Association of PeriOperative,Registered Nurses (AORN) 55th Congress ... reported being "very concerned" about the surgical,complications related ... facility was powder-free. Powdered gloves have been implicated ...
... The Chehalis,Confederated Tribes will host a special ... Casino May 17 and 18, tribal officials,announced this ... Honor Veterans Benefit," will provide much needed support ... the Freedoms Foundation,s,Return to Honor Program., "We,re ...
... Media, Inc. (AMI),today said that it has made ... to be disclosed on a monthly basis to ... Agreement., The information, which includes the average ... the period April 2007,through March 2008, as well ...
... Pa., April 7, 2008 Genaera,Corporation (Nasdaq: ... Rule 4350(b)(1)(B), that the audit report included in ... fiscal year ended December 31,2007 contained an unqualified ... KPMG LLP, which included a "going concern",explanatory paragraph. ...
... Pa., April 7, 2008 Consumers who,purchased raw ... Bethlehem, Clarion,County, and Clark and Elaine Duncan,s farm ... discard it immediately due to the risk of,Listeria ... Raw milk is milk that has not been ...
Cached Medicine News:Health News:Probable Case of Human-to-Human Bird Flu Transmission Reported 2Health News:Probable Case of Human-to-Human Bird Flu Transmission Reported 3Health News:Operating Room Nurses are Concerned about Complications Associated with Powdered Gloves 2Health News:Operating Room Nurses are Concerned about Complications Associated with Powdered Gloves 3Health News:Operating Room Nurses are Concerned about Complications Associated with Powdered Gloves 4Health News:Chehalis Tribes Announce Benefit to Help Returning Combat Veterans 2Health News:Genaera Corporation Receives Audit Opinion Containing Going Concern Explanatory Paragraph 2Health News:Genaera Corporation Receives Audit Opinion Containing Going Concern Explanatory Paragraph 3
(Date:5/20/2013)... May 20, 2013  Echo Pharma Acquisition Limited ("Royalty ... Irish Takeover Rules (the "Announcement"), a firm intention to ... ELN ) to $12.50 per share in cash.  ... not conditional on due diligence.  The $1.00 per share ... reserved the right to waive down the Acceptance Threshold ...
(Date:5/20/2013)... Calif. , May 20, 2013 A ... for use both in space and on Earth was ... The technology assures high quality, secure ... and low-power ultrasound units, like those used in hospitals ... already the diagnostic imaging solution of choice for human ...
(Date:5/20/2013)... , May 20, 2013 Sequent Medical, ... for the SL ("Single Layer") family of WEB ® ... release of these new models in select neurovascular centers ... and superior navigability that will enable physicians to treat ... The SL configurations are made possible by ...
Breaking Medicine Technology:Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 2Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 3Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 4Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 5Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 6Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 7Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 8Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 9Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 10Royalty Pharma Increases Offer for Elan to $12.50 Per Share in All Cash 11Wyle Aided System Gets Named to Space Technology Hall of Fame 2Wyle Aided System Gets Named to Space Technology Hall of Fame 3Sequent Medical, Inc. Launches New SL Family of WEB Aneurysm Embolization Devices 2
Shandon Stackable Slide Storage Cabinet...
The Slide and Paraffin Block Cabinets have versatile drawers which accomodate a variety of slides and paraffin blocks....
Modular Specimen Filing System has five cells that can hold either slides or tissue cassettes....
Shandon Cardboard Slide Folders...
Medicine Products: