Navigation Links
Stronger intestinal barrier may prevent cancer in the rest of the body, new study suggests
Date:2/21/2012

PHILADELPHIA A leaky gut may be the root of some cancers forming in the rest of the body, a new study published online Feb. 21 in PLoS ONE by Thomas Jefferson University researchers suggests.

It appears that the hormone receptor guanylyl cyclase C (GC-C)a previously identified tumor suppressor that exists in the intestinal tractplays a key role in strengthening the body's intestinal barrier, which helps separate the gut world from the rest of the body, and possibly keeps cancer at bay. Without the receptor, that barrier weakens.

A team led by Scott Waldman, M.D., Ph.D., chair of the Department of Pharmacology and Experimental Therapeutics at Jefferson and director of the Gastrointestinal Cancer Program at Jefferson's Kimmel Cancer Center, discovered in a pre-clinical study that silencing GC-C in mice compromised the integrity of the intestinal barrier. It allowed inflammation to occur and cancer-causing agents to seep out into the body, damaging DNA and forming cancer outside the intestine, including in the liver, lung and lymph nodes.

Conversely, stimulating GC-C in intestines in mice strengthened the intestinal barrier opposing these pathological changes.

A weakened intestinal barrier has been linked to many diseases, like inflammatory bowel disease, asthma and food allergies, but this study provides fresh evidence that GC-C plays a role in the integrity of the intestine. Strengthening it, the team says, could potentially protect people against inflammation and cancer in the rest of the body.

"If the intestinal barrier breaks down, it becomes a portal for stuff in the outside world to leak into the inside world," said Dr. Waldman. "When these worlds collide, it can cause many diseases, like inflammation and cancer."

The role of
'/>"/>

Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Healthier Diet, Stronger Sperm?
2. Women have stronger immune systems than men and its all down to a single chromosome
3. Stronger tobacco control policy in the Netherlands would save thousands of lives
4. College Football Players Get Bigger, Stronger With Age
5. Stronger social safety net leads to decrease in stress, childhood obesity
6. ACSM: Stronger hips improved running mechanics, lessened knee pain
7. Early Puberty Onset Linked to Stronger Bones
8. Parents Have Stronger Relationship When Dad Plays With Kids
9. Teens Breast-fed as Infants Have Stronger Leg Muscles
10. Sleep makes your memories stronger
11. Benefits of healthy lifestyle factors stronger in combination
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stronger intestinal barrier may prevent cancer in the rest of the body, new study suggests
(Date:7/29/2014)... TUESDAY, July 29, 2014 (HealthDay News) --,The time at ... affect their chances for survival, new research suggests. ... weekends or during holidays is associated with a 13 ... business hours, researchers report. Every year, more than ... most severe type of heart attack, which is caused ...
(Date:7/29/2014)... July 29, 2014 (HealthDay News) -- Chlorine helps keep ... more likely to develop eye infections, doctors say. ... as well as blurry vision, said Dr. Sampson Davis, ... in New Jersey. It,s important to understand why ... washes away the outer film layer of the eye ...
(Date:7/29/2014)... 29, 2014 The Board of Governors of ... Hart LLP ’s Connie Akridge to serve as ... as President of the Foundation. Akridge served as President of ... a partner at Holland & Hart in Las Vegas, providing ... matters to insurance and healthcare clients for more than 25 ...
(Date:7/29/2014)... 2014 Tylenol lawsuits ( http://www.tylenollawsuitclaims.com/ ... suffered serious liver injuries due to the acetaminophen ... a multidistrict litigation underway in U.S. District Court, ... According to an Order dated July 23rd, the ... bellwether case and discovery issues. Among other things, ...
(Date:7/29/2014)... Dennis Thompson HealthDay Reporter ... healthy diet and good sleep can protect the body against ... process at a cellular level, researchers report. A study ... linked to increased shortening of telomeres, the protective caps at ... "We found that over a one-year period, the more ...
Breaking Medicine News(10 mins):Health News:Heart Attack Patients Treated at Night, Weekends May Have Worse Outcomes 2Health News:Protect Your Eyes When Hitting the Pool 2Health News:Holland & Hart LLP Attorney Connie Akridge Reappointed Trustee of the Nevada Bar Foundation 2Health News:Tylenol Lawsuit News: Federal Court Overseeing Tylenol Liver Damage Claims Sets New Deadlines Pertaining to Discovery, Bellwether Trials, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: Federal Court Overseeing Tylenol Liver Damage Claims Sets New Deadlines Pertaining to Discovery, Bellwether Trials, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: Federal Court Overseeing Tylenol Liver Damage Claims Sets New Deadlines Pertaining to Discovery, Bellwether Trials, Bernstein Liebhard LLP Reports 4Health News:Healthy Habits May Slow Cellular Signs of Aging, Study Finds 2Health News:Healthy Habits May Slow Cellular Signs of Aging, Study Finds 3
... As the United States moves toward the goal of ... from the Regenstrief Institute provides a framework for evaluating the ... as the health internet. The study, which appears ... American Medical Informatics Association , also reports on the initial ...
... ... resource deployment through enhanced territory alignment , ... (PRWEB) May 11, 2010 -- The TerrAlign Group, Inc. a ... the inaugural launch of Veeva System’s Veeva Web™ program. Inclusion in this program ...
... So often the rare informs the common. Penn researchers ... have shown that it may be related to epileptic and ... A team of researchers from the University of Pennsylvania School ... professor of Neurology and director of the Penn Epilepsy Center, ...
... Oklahoma, Massachusetts asked to pull back products , TUESDAY, ... E.coli-tainted lettuce expanded late Monday as another food company ... farm currently under investigation by the U.S. Food and ... , According to the Associated Press , California-based ...
... Only ... ... KWizCom, a leading provider of critical SharePoint components to over 3,000 organizations around the ... giant AT&T. KWizCom’s Mobile Extensions , a smart phone connector that permits intelligent, ...
... Canvas Provides Health ... On Mobile Devices. , , ... Herndon, VA (PRWEB) May 11, 2010 -- Canvas announced today it had released ... HITECH compliant mobile applications on the Canvas service. The Health Insurance Portability and ...
Cached Medicine News:Health News:Measuring success: Regenstrief helps assess value of investment in health info tech 2Health News:TerrAlign Selected to Join Veeva System's Veeva Web Program 2Health News:TerrAlign Selected to Join Veeva System's Veeva Web Program 3Health News:TerrAlign Selected to Join Veeva System's Veeva Web Program 4Health News:Rare disease in Amish children sheds light on common neurological disorders 2Health News:Tainted Lettuce Recall Expands 2Health News:Tainted Lettuce Recall Expands 3Health News:KWizCom's Mobile Extensions for SharePoint Receive AT&T Certified Solutions Status 2Health News:HIPAA HITECH Compliant Mobile Apps Available for Android, Blackberry and Windows Mobile Smartphones 2Health News:HIPAA HITECH Compliant Mobile Apps Available for Android, Blackberry and Windows Mobile Smartphones 3Health News:HIPAA HITECH Compliant Mobile Apps Available for Android, Blackberry and Windows Mobile Smartphones 4
(Date:7/29/2014)... HILL, Conn. , July 29, 2014 Numotion,s ... 2014, Mike Swinford will be the company,s new ... a highly successful 22-year career at GE where he worked ... million in annual revenue to over $5 billion. His most ... Global Services. "I am thrilled to join ...
(Date:7/29/2014)... Fla. , July 29, 2014 /PRNewswire-iReach/ -- ... service provider, has launched its Medical Equipment ...  These services are tailored to the cruise ... standards prompted industry operators to propose that they ... MHG Medical,s new program is intended to create ...
(Date:7/29/2014)... 29, 2014  Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Chemistry (AACC) 2014 Clinical Lab Expo today by unveiling ... ways Roche is partnering with customers to redefine the ... us every day that they,re looking for a partner ... their labs and offices," said Jack Phillips , ...
Breaking Medicine Technology:Numotion Names Mike Swinford CEO 2MHG Medical Management Services Aims to Change Cruise Industry Standard With New Equipment Maintenance Program 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 3Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 4
... Schering-Plough Corporation,(NYSE: SGP ) today reported that ... Phase II study of boceprevir, its investigational oral ... chronic,hepatitis C virus (HCV) genotype 1 were presented ... for the Study of the Liver (EASL). The,ongoing ...
... Into New Promising Drugs to Combat Hepatitis ... C ... Stem Cells of Potential Benefit in Liver Transplantation, ... At today,s sessions of the 43rd Annual Meeting of the European,Association for the ...
Cached Medicine Technology:Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL 2Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL 3Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL 4Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL 5Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL 6Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL 7Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL 8Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment-Naive Hepatitis C Patients Presented At EASL 9Basic Science Discoveries Yield Progress in Hepatology 2Basic Science Discoveries Yield Progress in Hepatology 3Basic Science Discoveries Yield Progress in Hepatology 4
... Spatula Tips That Mimic Corneal Curvature. Designed To ... Created With The IntraLase TMFS Laser System., ... Of The Forceps Are Designed To Facilitate Access ... Achieved, The Cross-Action Forceps Design Allows The Surgeon ...
... Allowing The Exact,Outer Diameter Measurement Of A ... ,Increments.,Easy And Quick To Use, With One-HandedOperation. ... Over A Cornea For Confirmation Of Exact ... ,Guaranteed For ...
... Safely And Easily Cut Foldable Lenses Through ... The Incision., ,Specially Designed To Cut And ... Lenses With Ease With One Instrument., ,Ideal ... Lenses Which Are Damaged, The Wrong Diopter ...
... Gauge Measures 360 Degrees & Can Be ... A Cornea. 7mm Inner Diameter & 14mm Outer ... Only Astigmatism Gauge That Can Be Set For ... Degree Around The Globe., ,Marks Single Or Paired ...
Medicine Products: