Navigation Links
Strong evidence supports prognostic value of circulating tumor cells in breast cancer
Date:5/5/2011

French researchers have reported the strongest proof yet that evidence of 'circulating tumor cells' found in samples of a patient's blood is strongly linked to poor outcomes such as a short time to disease progression.

At the IMPAKT Breast Cancer Conference in Brussels, Dr Franois-Clement Bidard and colleagues from Institut Curie in Paris say their new findings set the scene for interventional trials designed to see if improved outcomes can be achieved by modifying treatment based on circulating tumor cell counts.

"We needed to do this study to confirm data provided by earlier small studies," Dr Bidard said. "Now we are certain that circulating tumor cells (CTC) are prognostic at baseline, and that CTC changes under treatment may be an early indicator of chemotherapy efficiency."

"In metastatic breast cancer, it is time now for interventional randomized trials which will try to demonstrate that CTC-based strategies of treatment lead to a better clinical outcome, or at least to a benefit in the cost/efficacy ratio of treatment," Dr Bidard said.

The French team conducted a prospective study in 267 patients who were receiving first-line chemotherapy for metastatic breast cancer. For each patient they performed a count of circulating tumor cells, plus an analysis of other blood markers, in 7.5ml of blood. They took their measurements at the beginning of treatment and at several later time points.

Of 260 patients who were evaluable for CTC levels at baseline, 170 (65%) had at least one circulating tumor cell per 7.5 ml blood sample, and 115 (44%) had five or more, the researchers found.

At the end of the study, a multivariate analysis of their results showed that several factors, including CTC counts, were correlated with disease progression and overall survival.

"This is the first study that has been prospectively designed and statistically powered for reporting CTC-associated outcome as primary end
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Use of costly breast cancer therapy strongly influenced by reimbursement policy
2. Study Finds Strong Smoking-Asthma Link
3. New vaccine candidate shows strong potential to prevent highly contagious norovirus
4. Strong link found between victimization, substance abuse
5. Early Puberty Onset Linked to Stronger Bones
6. Parents Have Stronger Relationship When Dad Plays With Kids
7. Having a strong community protects adolescents from risky health behaviors
8. Novel immune system-based gene therapy induces strong responses in metastatic melanoma, sarcoma
9. Study Finds Round Numbers Are Strong Motivators
10. Strong social ties benefit breast cancer patients
11. Teens Breast-fed as Infants Have Stronger Leg Muscles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Randy Dotinga HealthDay Reporter ... who have the largest number of post-traumatic stress disorder symptoms ... to food, a new study suggests. The findings ... or becoming addicted to food. And it,s also possible that ... PTSD, or both. Still, the research seems to ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Fit Body ... the fastest-selling fitness business in the country and its popularity, ... has continued to grow enormously in 2014. , The ... Conference, is taking place in Costa Mesa, CA on September ... the biggest conferences yet. Founder Bedros Keuilian, who is also ...
(Date:9/18/2014)... It is true that a ... building a successful brand or business online. Best ... recently compared plenty of professional web hosting suppliers ... and iPage are the best VPS hosting suppliers ... web hosting. All-sized businesses or enterprises can find ...
(Date:9/18/2014)... 18, 2014 In Pretrial Order ... Compel Discovery; Motion for Protective Order ), the ... the subject of multiple telephone conferences.” The first ... “new process for the collection, retention, storage, and ... mesh revision or removal procedures,” which process was ...
(Date:9/18/2014)... September 18, 2014 SMI ... MEMS low pressure sensor Series designed especially ... accuracy. The unique gage and differential offering allows ... 14-Bit resolution and 1% accuracy provide the user ... per year provides the reliability and long-term reliability ...
Breaking Medicine News(10 mins):Health News:PTSD Link to Food Addiction Seen in Report 2Health News:PTSD Link to Food Addiction Seen in Report 3Health News:With Fit Body Boot Camp World Conference Nearing, Founder Explains the Fitness Boot Camp Franchise’s Success 2Health News:With Fit Body Boot Camp World Conference Nearing, Founder Explains the Fitness Boot Camp Franchise’s Success 3Health News:Best Cheap Hosting USA: GreenGeeks, Arvixe And iPage Are The Best Hosting Suppliers In 2014 2Health News:Transvaginal Mesh Lawsuit News: Court Orders C.R. Bard to Turn Over Relevant Documents to Plaintiffs, the Rottenstein Law Group LLP Reports 2Health News:SMI Launches Digital MEMS Low Pressure Sensor 2
... , MONDAY, June 21 (HealthDay News) -- Using ear tubes ... cochlear implants, a new study finds. , U.S. researchers studied ... received ear tubes before cochlear implants. In 46 (59 percent) ... implantation surgery. In all the other cases, the ear tubes ...
... likely to develop allergies, asthma, study suggests , ... born vaginally pick up different bacteria than those who ... immune systems develop, a new study suggests. , ... born through cesarean sections appear to be more at ...
... DC) A recent study of an ancient language ... with potential applications for today,s world. The study, "Dvandvas, ... to Word," to be published in the June 2010 ... authored by Paul Kiparsky of Stanford University. A preprint ...
... the industrial chemical bisphenol A, or BPA, in the womb ... according to a new study conducted in animals. The results ... Meeting in San Diego. "We are seeing changes in ... that are lower than what the Food and Drug Administration ...
... 21, 2010 The recent revelation that the chair ... (IDRC) was a tobacco executive until April 2010 sends ... is no longer a priority, states an editorial ... ). "There is simply no place for the ...
... ... there is promoter activity behind the website. , ... (PRWEB) June 21, 2010 -- The Active Search Results Search Engine ( ... Ranking Technology (ASR Ranking). , , ,ASR Ranking allows search engines to rank search ...
Cached Medicine News:Health News:Ear Tubes Appear to Be Safe Before Cochlear Implantation 2Health News:Delivery Method May Determine the Bacteria Babies Acquire 2Health News:Delivery Method May Determine the Bacteria Babies Acquire 3Health News:The 'bumpy ride' of linguistic change 2Health News:Early-life exposure to BPA may affect testis function in adulthood 2Health News:CMAJ calls for resignation of IDRC chair Barbara McDougall 2Health News:Active Search Results Announces its New Search Engine Ranking Algorithm 2Health News:Active Search Results Announces its New Search Engine Ranking Algorithm 3
(Date:9/17/2014)... , Sept. 17, 2014 BRIC ... Summary GlobalData,s new report, "BRIC ... market data on the BRIC Gynecological Devices market. ... dollars, volume (in units) and average prices (in ... Devices (Transcervical Sterilization Devices (Micro-inserts) and Mechanical Sterilization ...
(Date:9/17/2014)... , Sept. 17, 2014 The ... the last decade due to the recession, ... and technological advancements. This BCC Research report ... segments of the ambulance and emergency medical ... blood and hemorrhage control devices, equipment used ...
(Date:9/17/2014)... 17, 2014 Pomerantz LLP is investigating claims ... BioPharma" or the "Company") (NASDAQ: PDLI).  Such investors are ... rswilloughby@pomlaw.com or 888-476-6529, ext. 237. ... its officers and/or directors have violated Sections 10(b) and ... On September 17, 2014, the Company announced ...
Breaking Medicine Technology:BRIC Gynecological Devices Market Outlook to 2020 2BRIC Gynecological Devices Market Outlook to 2020 3Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of PDL BioPharma, Inc. - PDLI 2
... Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... subsidiaries, Valeant Pharmaceuticals North America LLC (VPNA) and ... agreement to acquire the assets of the Ortho ... pay Janssen $345 million for the assets, which ...
... Inc. (Nasdaq: CPIX ) announced today that ... market closes on Thursday, August 4, 2011.  A conference call ... 4, 2011, at 5:00 p.m. Eastern Time to discuss the ... 877-303-1298 (for U.S. callers) or 253-237-1032 (for international callers).  A ...
Cached Medicine Technology:Valeant Pharmaceuticals Agrees to Acquire Ortho Dermatologics 2Valeant Pharmaceuticals Agrees to Acquire Ortho Dermatologics 3
... centrifuges -- the world's most popular Microhematocrit ... one reliable, quiet, compact unit. It is ... separate centrifuges!, For your microcentrifuge needs, order ... you with the MicroMB centrifuge, microcentrifuge rotor ...
... spins up to 25,000 x g for quick and ... ease of use. The Model 5417 C is designed ... cold room and can accommodate a variety of microcentrifuge ... Spin up to 16,400 rpm; 25,000 x g ...
... The Model EXD explosion-proof laboratory floor model ... explosion-proof apparatus. EXD is suitable for use ... all divisions; "atmospheres containing gasoline, petroleum, naphtha, ... Adherence to these specifications is so strict ...
... Oven/Shaker rigidly controls the temperature and ... hybridization and washing steps. This facilitates ... nucleic acids and proteins immobilized on ... radioactive and nonradioactive labeling systems supplied ...
Medicine Products: