Navigation Links
Strong evidence supports prognostic value of circulating tumor cells in breast cancer
Date:5/5/2011

French researchers have reported the strongest proof yet that evidence of 'circulating tumor cells' found in samples of a patient's blood is strongly linked to poor outcomes such as a short time to disease progression.

At the IMPAKT Breast Cancer Conference in Brussels, Dr Franois-Clement Bidard and colleagues from Institut Curie in Paris say their new findings set the scene for interventional trials designed to see if improved outcomes can be achieved by modifying treatment based on circulating tumor cell counts.

"We needed to do this study to confirm data provided by earlier small studies," Dr Bidard said. "Now we are certain that circulating tumor cells (CTC) are prognostic at baseline, and that CTC changes under treatment may be an early indicator of chemotherapy efficiency."

"In metastatic breast cancer, it is time now for interventional randomized trials which will try to demonstrate that CTC-based strategies of treatment lead to a better clinical outcome, or at least to a benefit in the cost/efficacy ratio of treatment," Dr Bidard said.

The French team conducted a prospective study in 267 patients who were receiving first-line chemotherapy for metastatic breast cancer. For each patient they performed a count of circulating tumor cells, plus an analysis of other blood markers, in 7.5ml of blood. They took their measurements at the beginning of treatment and at several later time points.

Of 260 patients who were evaluable for CTC levels at baseline, 170 (65%) had at least one circulating tumor cell per 7.5 ml blood sample, and 115 (44%) had five or more, the researchers found.

At the end of the study, a multivariate analysis of their results showed that several factors, including CTC counts, were correlated with disease progression and overall survival.

"This is the first study that has been prospectively designed and statistically powered for reporting CTC-associated outcome as primary endpoint in a homogeneous population of metastatic breast cancer patients treated first line," Dr Bidard said.

The study results also add evidence to an ongoing discussion about how many CTCs per blood sample should be used to define patients at 'high risk' for a poor outcome.

"Generally, the more CTC you have, the worse it is," Dr Bidard said. "However, to define a 'high risk group', a threshold is needed. We report that the relative risk of the high-risk group vs low-risk group does not significantly change whether you define it as having a threshold of 1 CTC or 5 CTC. In both cases, their relative risks of shorter progression-free survival compared to the low-risk group are statistically the same."

"Our data suggest that using the lower threshold of 1 CTC is feasible and is not affected by any major loss of specificity of CTC detection. This supports the use of this low threshold in other studies conducted in non-metastatic breast cancer patients."

Commenting the study, which he was not involved in, Prof Fortunato Ciardiello, from Seconda Universit di Napoli, Naples, Italy, noted that circulating tumor cells have been suggested in recent times as a useful prognostic marker for several cancers, including breast cancer.

"This study is very relevant, since it gives a prospective evaluation of the role of CTC in a large series of metastatic breast cancer patients receiving first-line treatment. It represents a significant contribution confirming the prognostic role of CTC and gives important insights to establish a clinically useful threshold level for defining patients with high or low circulating tumor cells."


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Related medicine news :

1. Use of costly breast cancer therapy strongly influenced by reimbursement policy
2. Study Finds Strong Smoking-Asthma Link
3. New vaccine candidate shows strong potential to prevent highly contagious norovirus
4. Strong link found between victimization, substance abuse
5. Early Puberty Onset Linked to Stronger Bones
6. Parents Have Stronger Relationship When Dad Plays With Kids
7. Having a strong community protects adolescents from risky health behaviors
8. Novel immune system-based gene therapy induces strong responses in metastatic melanoma, sarcoma
9. Study Finds Round Numbers Are Strong Motivators
10. Strong social ties benefit breast cancer patients
11. Teens Breast-fed as Infants Have Stronger Leg Muscles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... , ... February 09, 2016 , ... ... helping businesses recover after a disaster, announced today the acquisition of Hawaii DKI. ... Hawaii. , “Investing in like-minded companies who excel at service and ...
(Date:2/9/2016)... Cambridge, MA (PRWEB) , ... February 09, 2016 ... ... Institute (WCRI) compares the workers’ compensation fee schedule rates and Medicare rates for ... medical services covered in the report, Evaluation of the 2015 Fee Schedule ...
(Date:2/9/2016)... Springs, FL (PRWEB) , ... February 09, 2016 ... ... leading innovative specialty pharmacies, announces today the continuation of the ‘Pay It Forward’ ... for each prescription referral received at our specialty pharmacy. , “Since our ...
(Date:2/9/2016)... ... 10, 2016 , ... The Journal of Pain Research has published ... .” , As corresponding author Dr John F. Peppin says “Terminology matters, yet little ... chronic pain patients. ‘Chronic cancer pain’ and ‘chronic non-cancer pain’ are replete in ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... service to expand access to affordable hearing aids , increase industry transparency, ... individuals in the United States. , “For the average consumer, the hearing aid ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... Feb.8, 2016 Cardiac Assist ... Summary GlobalData,s Medical Devices sector report, " ... 2015 " provides an overview of Cardiac Assist ... provides comprehensive information on the pipeline products with ... of development. The report reviews major players involved ...
(Date:2/8/2016)... -- Respiratory Devices - Medical Devices Pipeline Assessment, ... report, " Respiratory Devices - Medical Devices Pipeline ... Devices currently in pipeline stage. The report ... comparative analysis of the products at various stages ... in the pipeline product development. It also provides ...
(Date:2/8/2016)... Devices - Medical Devices Pipeline Assessment, 2015 Summary ... Medical Devices Pipeline Assessment, 2015" provides an overview of ... This report is prepared using data sourced from in-house ... industry experts. *Note: Certain sections in the report ... and relevance of data in relation to the equipment ...
Breaking Medicine Technology: