Navigation Links
Strong evidence supports prognostic value of circulating tumor cells in breast cancer
Date:5/5/2011

French researchers have reported the strongest proof yet that evidence of 'circulating tumor cells' found in samples of a patient's blood is strongly linked to poor outcomes such as a short time to disease progression.

At the IMPAKT Breast Cancer Conference in Brussels, Dr Franois-Clement Bidard and colleagues from Institut Curie in Paris say their new findings set the scene for interventional trials designed to see if improved outcomes can be achieved by modifying treatment based on circulating tumor cell counts.

"We needed to do this study to confirm data provided by earlier small studies," Dr Bidard said. "Now we are certain that circulating tumor cells (CTC) are prognostic at baseline, and that CTC changes under treatment may be an early indicator of chemotherapy efficiency."

"In metastatic breast cancer, it is time now for interventional randomized trials which will try to demonstrate that CTC-based strategies of treatment lead to a better clinical outcome, or at least to a benefit in the cost/efficacy ratio of treatment," Dr Bidard said.

The French team conducted a prospective study in 267 patients who were receiving first-line chemotherapy for metastatic breast cancer. For each patient they performed a count of circulating tumor cells, plus an analysis of other blood markers, in 7.5ml of blood. They took their measurements at the beginning of treatment and at several later time points.

Of 260 patients who were evaluable for CTC levels at baseline, 170 (65%) had at least one circulating tumor cell per 7.5 ml blood sample, and 115 (44%) had five or more, the researchers found.

At the end of the study, a multivariate analysis of their results showed that several factors, including CTC counts, were correlated with disease progression and overall survival.

"This is the first study that has been prospectively designed and statistically powered for reporting CTC-associated outcome as primary end
'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Use of costly breast cancer therapy strongly influenced by reimbursement policy
2. Study Finds Strong Smoking-Asthma Link
3. New vaccine candidate shows strong potential to prevent highly contagious norovirus
4. Strong link found between victimization, substance abuse
5. Early Puberty Onset Linked to Stronger Bones
6. Parents Have Stronger Relationship When Dad Plays With Kids
7. Having a strong community protects adolescents from risky health behaviors
8. Novel immune system-based gene therapy induces strong responses in metastatic melanoma, sarcoma
9. Study Finds Round Numbers Are Strong Motivators
10. Strong social ties benefit breast cancer patients
11. Teens Breast-fed as Infants Have Stronger Leg Muscles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Colorado (PRWEB) July 29, 2014 Daily ... that the program was actually created by a popular ... too. He tried numerous treatments for this disorder, but ... found himself in the situation of having to look ... years of research. Dawson used this method, too, to ...
(Date:7/29/2014)... Advertising claims for cosmetic procedures using stem cells ... safety and effectiveness, according to a review in the ... , the official medical journal of the ... cells offer tremendous potential, but the marketplace is saturated ... patients at risk," write Dr Michael T. Longaker of ...
(Date:7/29/2014)... Angeles, CA (PRWEB) July 29, 2014 ... the website of Time Magazine titled “From Kim’s Butt ... Kim Kardashian’s butt is the celebrity feature ... and their features include Beyoncé’s butt, Jennifer Lawrence’s ... lips. This information is based on data collected by ...
(Date:7/29/2014)... 29, 2014 Tylenol lawsuits ( ... allegedly suffered serious liver injuries due to the ... in a multidistrict litigation underway in U.S. District ... reports. According to an Order dated July 23rd, ... to bellwether case and discovery issues. Among other ...
(Date:7/29/2014)... Avenidas is always looking for ... again, the non-profit agency is doing just that with the ... , This event gives seniors the opportunity to learn about ... will be a variety of fun activities, including a Tai ... and artists. In addition, there will be food tastings, courtesy ...
Breaking Medicine News(10 mins):Health News:Natural Vitiligo Treatment System Review Reveals Michael Dawson’s New Vitiligo Cure Program 2Health News:Beware of claims about cosmetic stem cells procedures, says review in Plastic and Reconstructive Surgery 2Health News:Celebrity Plastic Surgery: Kim Kardashian’s Butt Tops the List of Celebrity Plastic Surgery Requests 2Health News:Tylenol Lawsuit News: Federal Court Overseeing Tylenol Liver Damage Claims Sets New Deadlines Pertaining to Discovery, Bellwether Trials, Bernstein Liebhard LLP Reports 2Health News:Tylenol Lawsuit News: Federal Court Overseeing Tylenol Liver Damage Claims Sets New Deadlines Pertaining to Discovery, Bellwether Trials, Bernstein Liebhard LLP Reports 3Health News:Tylenol Lawsuit News: Federal Court Overseeing Tylenol Liver Damage Claims Sets New Deadlines Pertaining to Discovery, Bellwether Trials, Bernstein Liebhard LLP Reports 4Health News:Avenidas Hosts Third Annual Successful Aging Celebration 2
... Total hip arthroplasty (THA), or hip replacement, is ... studies have only followed patients for up to ... December issue of Arthritis Care & Research ( ... eight years following hip replacement and found a ...
... obtained agreement with the United States, Food and Drug ... SP1049C for the treatment of metastatic adenocarcinoma of the ... upper gastrointestinal tract, ... clinical trial will compare SP1049C plus Best Supportive Care (BSC),versus BSC ...
... Flick, presents World AIDS Day Special ... SIRIUS Satellite Radio,Interview with Madonna and exclusive performances from Cyndi Lauper, Indigo ... Bell and others, NEW YORK, Nov. 28 SIRIUS Satellite Radio,(Nasdaq: ... --,Saturday, December 1 -- with an exclusive broadcast event on SIRIUS OutQ,109, ...
... Over the past few weeks,there has been a ... the meat industry and the USDA that permits ... failed to be "non-negative" for E.,coli O157:H7,( http://www.ehagroup.com/epidemiology/illnesses/e-coli-O157-H7.asp ... includes cooking to the thermal death,stage for all ...
... Breast cancer is a disease with a number ... have seen that these risks are often compounded by ... exactly, do social disadvantages, genetics, race and culture add ... women? , These are among the questions in ...
... of Americans still weigh much too much, study finds , , ... hasn,t increased much in recent years, but there are still ... study reports. , The study, based on 2005-06 data from ... , More than a third of American adults (about 72 ...
Cached Medicine News:Health News:Long-term improvement seen with hip replacement 2Health News:Supratek Pharma Inc. announced today that under the Special Protocol 2Health News:SIRIUS OutQ Honors International Day of AIDS Awareness 2Health News:SIRIUS OutQ Honors International Day of AIDS Awareness 3Health News:The USDA 'E. coli Loophole' in Ground Beef: Much Ado About Nothing 2Health News:The USDA 'E. coli Loophole' in Ground Beef: Much Ado About Nothing 3Health News:New perspectives on health disparities in breast cancer research 2Health News:New perspectives on health disparities in breast cancer research 3Health News:New perspectives on health disparities in breast cancer research 4Health News:New perspectives on health disparities in breast cancer research 5Health News:New perspectives on health disparities in breast cancer research 6Health News:New perspectives on health disparities in breast cancer research 7Health News:New perspectives on health disparities in breast cancer research 8Health News:Obesity Rates Leveling Off Among U.S. Adults 2
(Date:7/29/2014)... YORK , July 29, 2014  Longtime industry ... Caremark Rx, Drew Crawford today announced the ... the leading independent media source dedicated to delivering fair, ... on the pharmacy benefit management (PBM) industry .  ... of, and context behind, industry news.   The outlet will ...
(Date:7/29/2014)... , July 29, 2014 McGraw-Hill Education Professional, ... the science, technical, and medical communities, has announced the ... off-line mobile application of the world-renowned medical education platform. ... AccessMedicine App , available for download onto all ... be able to gain access to valuable AccessMedicine ...
(Date:7/29/2014)... According to a new market ... Devices Market - Global Forecast, Market Share, Size, Growth ... trauma fixation devices market is estimated at USD 6.1 ... a CAGR of 7.2% from 2014 to 2019, to ... 2020. Browse the Orthopedic Trauma Fixation Devices ...
Breaking Medicine Technology:Drew Crawford Announces Launch of PBM365 Media 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 3Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 2Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 3Orthopedic Trauma Fixation Devices Market is Expected to Reach USD 9.3 Billion Globally in 2020: Transparency Market Research 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: