Navigation Links
Stroma may provide key to better cancer treatment
Date:10/25/2010

A project focusing on the scar tissue surrounding cancer tumours aims to provide new targets for drugs for treating pancreatic cancer, the fifth highest cause of cancer deaths in the UK.

Funded by the UK charity Pancreatic Cancer Research Fund, the project will research the role of a family of molecules present in this scar tissue - known as stroma - which are believed to have a role in driving tumour growth.

The project is led by surgeon and researcher Mr Hemant Kocher from Barts and The London School of Medicine and Dentistry.

The research is based on the 'seed and soil' hypothesis, where the cancer is the 'seed' and the stroma the 'soil'. Mr Kocher explains: "We believe the stroma provides the right environment in which the cancer can grow. All cancers have stroma, but in pancreatic cancer, it's markedly more voluminous, which may prevent drug treatments reaching the tumour."

"The pancreatic cancer stroma has not, to date, been targeted as a potential route for treatment," says Mr Kocher. "The survival rate for pancreatic cancer hasn't improved in around 40 years, and we're hopeful this research will shed greater light on this area."

The team will be conducting in-depth analysis of a family of signalling molecules called Fibroblast Growth Factor (FGF) drawing on knowledge gained through progress in breast cancer research.

"A gene which was found to be implicated in breast cancer has been shown to code a receptor for FGF," says Mr Kocher. "If we can understand how FGF receptor gene regulates cell behaviour, we'll be able to harness this knowledge in the search for better drug treatments."

The research team includes PhD student Stacey Coleman and will draw on the expertise of cell biologist Dr Richard Grose also at the Institute of Cancer at Barts & The London School of Medicine & Dentistry - who has focused on these mechanisms in the search for more effective breast cancer treatments.


'/>"/>

Contact: Alex Fernandes
a.fernandes@qmul.ac.uk
44-020-782-27910
Queen Mary, University of London
Source:Eurekalert

Related medicine news :

1. Optimal surgical procedure for duodenal gastrointestinal stromal tumors
2. MSU tasked with educating health-care providers on fish consumption
3. Patient-provider language barriers linked to worse diabetes control
4. Pediatric field hospital in Haiti provides lessons in disaster planning and response
5. Circulating tumor cells can provide real-time information on patients current disease state
6. Women and Infants provides fertility preservation for childhood cancer survivors
7. The University of Warsaw obtains 3-year site license to Science to provide site-wide access to research institutions in Poland
8. Curry cooking ingredient could provide recipe for fight against cancer
9. JAK inhibitor provides rapid, durable relief for myelofibrosis patients
10. Elsevier partners with ASRT to provide multimedia educational modules through Mosbys Imaging Suite
11. Selected cells from blood or bone marrow may provide a route to healing blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/13/2017)... ... 2017 , ... “America On The Brink”: the Christian history of the United ... the creation of published author, William Nowers. Captain Nowers and his wife, Millie, ... spent thirty years in the Navy. Following his career as a naval aviator ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... sleep apnea using cutting-edge Oventus O2Vent technology. As many as 18 ... characterized by frequent cessation in breathing. Oral appliances can offer significant relief to ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... to meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s ... experts and tested to meet the highest standard. , These products are ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... Sept. 19, 2017   ZirMed Inc ., a recognized ... announced that it has been ranked #1 by its users ... Rankings 2017 User Survey. ZirMed was recognized as the ... hospitals and medical centers over 200 beds and holds one ... technology user survey history. ...
(Date:9/13/2017)... has been named the official orthopedic and sports medicine ... 2018 College Football Playoff (CFP) National Championship to be played ... Atlanta, Georgia . OrthoAtlanta is proud to be ... many activities leading up to, and including the national championship ... OrthoAtlanta serves ...
(Date:9/12/2017)... 12, 2017  ValGenesis Inc., the global leader ... pleased to announce the appointment of Dr. ... Board of Directors and Chairman of Advisory Board ... science companies to manage their entire validation lifecycle ... in this process. Furthermore, ValGenesis VLMS enables rigorous ...
Breaking Medicine Technology: