Navigation Links
Stroma may provide key to better cancer treatment
Date:10/25/2010

A project focusing on the scar tissue surrounding cancer tumours aims to provide new targets for drugs for treating pancreatic cancer, the fifth highest cause of cancer deaths in the UK.

Funded by the UK charity Pancreatic Cancer Research Fund, the project will research the role of a family of molecules present in this scar tissue - known as stroma - which are believed to have a role in driving tumour growth.

The project is led by surgeon and researcher Mr Hemant Kocher from Barts and The London School of Medicine and Dentistry.

The research is based on the 'seed and soil' hypothesis, where the cancer is the 'seed' and the stroma the 'soil'. Mr Kocher explains: "We believe the stroma provides the right environment in which the cancer can grow. All cancers have stroma, but in pancreatic cancer, it's markedly more voluminous, which may prevent drug treatments reaching the tumour."

"The pancreatic cancer stroma has not, to date, been targeted as a potential route for treatment," says Mr Kocher. "The survival rate for pancreatic cancer hasn't improved in around 40 years, and we're hopeful this research will shed greater light on this area."

The team will be conducting in-depth analysis of a family of signalling molecules called Fibroblast Growth Factor (FGF) drawing on knowledge gained through progress in breast cancer research.

"A gene which was found to be implicated in breast cancer has been shown to code a receptor for FGF," says Mr Kocher. "If we can understand how FGF receptor gene regulates cell behaviour, we'll be able to harness this knowledge in the search for better drug treatments."

The research team includes PhD student Stacey Coleman and will draw on the expertise of cell biologist Dr Richard Grose also at the Institute of Cancer at Barts & The London School of Medicine & Dentistry - who has focused on these mechanisms in the search for more effective breast cancer treatments.


'/>"/>

Contact: Alex Fernandes
a.fernandes@qmul.ac.uk
44-020-782-27910
Queen Mary, University of London
Source:Eurekalert

Related medicine news :

1. Optimal surgical procedure for duodenal gastrointestinal stromal tumors
2. MSU tasked with educating health-care providers on fish consumption
3. Patient-provider language barriers linked to worse diabetes control
4. Pediatric field hospital in Haiti provides lessons in disaster planning and response
5. Circulating tumor cells can provide real-time information on patients current disease state
6. Women and Infants provides fertility preservation for childhood cancer survivors
7. The University of Warsaw obtains 3-year site license to Science to provide site-wide access to research institutions in Poland
8. Curry cooking ingredient could provide recipe for fight against cancer
9. JAK inhibitor provides rapid, durable relief for myelofibrosis patients
10. Elsevier partners with ASRT to provide multimedia educational modules through Mosbys Imaging Suite
11. Selected cells from blood or bone marrow may provide a route to healing blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... 2017 , ... Veteran Theresa James awoke to the sound of her newly ... “Healing Tears,” James depicts every parent’s worst nightmare, when her three children were violently ... and situations throughout my divorce,” James said. “After the death of my children, I ...
(Date:4/24/2017)... ... ... My T Chai, a South African company that creates a number of ... a popular website specializing in sales of nutritional products. , Chai tea is ... It spread across Asia and Africa quickly, and today recipes vary from region to ...
(Date:4/24/2017)... ... April 24, 2017 , ... In 2017, up to ... approximately 25,000 of them will be malignant.(1) As research into precision medicine continues, ... healthcare model in the diagnosis and treatment of brain tumors. Healthcare facilities that ...
(Date:4/24/2017)... ... 2017 , ... As a former supermodel known for her timeless beauty, Joan ... single women is that she put all the words in her new book, "Manifest ... personal experiences and sparkling sense of humor have inspired her to write a book ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... shows that over the last decade, student well-being has seriously declined. "When disenfranchised ... of formal education, join the Islamic State to turn the historic multi-ethnic and ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , Tenn. and DALLAS , April ... EndoStim, Inc., announced that the first patients in ... the EndoStim device in the Lower Esophageal Sphincter Stimulation ... a minimally-invasive implantable device designed to provide long-term reflux ... neurostimulation. GERD affects nearly 65 million people ...
(Date:4/19/2017)... , April 19, 2017 ... stimulate an immune response in pets such as ... products are of various types such as Attenuated ... Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated ... as virus or bacteria, which have been weakend ...
(Date:4/19/2017)... 2017  SARES•REGIS Group leased the first of ... Conejo Spectrum Business Park in Thousand ... Inc. , a biopharmaceutical company developing meaningful therapies ... have been underserved by scientific innovation, with an ... autoimmune and infectious disease. Before commencement ...
Breaking Medicine Technology: