Navigation Links
Stroma may provide key to better cancer treatment
Date:10/25/2010

A project focusing on the scar tissue surrounding cancer tumours aims to provide new targets for drugs for treating pancreatic cancer, the fifth highest cause of cancer deaths in the UK.

Funded by the UK charity Pancreatic Cancer Research Fund, the project will research the role of a family of molecules present in this scar tissue - known as stroma - which are believed to have a role in driving tumour growth.

The project is led by surgeon and researcher Mr Hemant Kocher from Barts and The London School of Medicine and Dentistry.

The research is based on the 'seed and soil' hypothesis, where the cancer is the 'seed' and the stroma the 'soil'. Mr Kocher explains: "We believe the stroma provides the right environment in which the cancer can grow. All cancers have stroma, but in pancreatic cancer, it's markedly more voluminous, which may prevent drug treatments reaching the tumour."

"The pancreatic cancer stroma has not, to date, been targeted as a potential route for treatment," says Mr Kocher. "The survival rate for pancreatic cancer hasn't improved in around 40 years, and we're hopeful this research will shed greater light on this area."

The team will be conducting in-depth analysis of a family of signalling molecules called Fibroblast Growth Factor (FGF) drawing on knowledge gained through progress in breast cancer research.

"A gene which was found to be implicated in breast cancer has been shown to code a receptor for FGF," says Mr Kocher. "If we can understand how FGF receptor gene regulates cell behaviour, we'll be able to harness this knowledge in the search for better drug treatments."

The research team includes PhD student Stacey Coleman and will draw on the expertise of cell biologist Dr Richard Grose also at the Institute of Cancer at Barts & The London School of Medicine & Dentistry - who has focused on these mechanisms in the search for more effective breast cancer treatments.


'/>"/>

Contact: Alex Fernandes
a.fernandes@qmul.ac.uk
44-020-782-27910
Queen Mary, University of London
Source:Eurekalert

Related medicine news :

1. Optimal surgical procedure for duodenal gastrointestinal stromal tumors
2. MSU tasked with educating health-care providers on fish consumption
3. Patient-provider language barriers linked to worse diabetes control
4. Pediatric field hospital in Haiti provides lessons in disaster planning and response
5. Circulating tumor cells can provide real-time information on patients current disease state
6. Women and Infants provides fertility preservation for childhood cancer survivors
7. The University of Warsaw obtains 3-year site license to Science to provide site-wide access to research institutions in Poland
8. Curry cooking ingredient could provide recipe for fight against cancer
9. JAK inhibitor provides rapid, durable relief for myelofibrosis patients
10. Elsevier partners with ASRT to provide multimedia educational modules through Mosbys Imaging Suite
11. Selected cells from blood or bone marrow may provide a route to healing blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2016)... ... May 29, 2016 , ... "With 30 unique self-animating web themed intros and ... of their project," said Christina Austin - CEO of Pixel Film Studios. , ... for use in Final Cut Pro X. Pixel Film Studios’ minimalistic titles allow users ...
(Date:5/28/2016)... ... ... city where’s it’s easy to spot the neon lights of chains serving fast food, one ... a taste for real food. , On May 13, the Best Western Plus ... restaurant focusing on dishes made by hand with wholesome, organic ingredients that are sourced locally ...
(Date:5/27/2016)... ... May 27, 2016 , ... An influential resource amongst nurses ... time to shed lights on the variety of topics detailing why we appreciate nurses ... tackles why this career has gone from being in a major recession to one ...
(Date:5/27/2016)... ... ... Beleza Medspa has initiated a new program to assist active duty ... that Coolsculpting is being used for for more than just cosmetic purposes. ... prescribed body-fat standard, measured by the circumference-based tape method. The tape-test is used ...
(Date:5/26/2016)... (PRWEB) , ... May 26, 2016 , ... Despite last ... meeting, expect Janet Yellen and company to wait until March 2017 for an interest ... University’s J. Mack Robinson College of Business. , “The Federal Open Market Committee (FOMC) ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 2016 A key trend that ... emergence of new treatments. Cardax, a development stage life ... The therapy is expected to fulfil large unmet medical ... conducting studies to develop new treatments for osteoarthritis. One ... involved in osteoarthritis are being investigated, and early trials ...
(Date:5/26/2016)... 26, 2016   Change Healthcare , ... network solutions and technology-enabled services designed to ... into a strategic channel partnership with SourceMed, ... solutions and revenue cycle management services that ... rehabilitation clinics to optimize revenue, operational efficiency ...
(Date:5/25/2016)... , May 25,2016 FDA ... near-infrared Cellvizio platform for urological and surgical applications ... MKEAY) inventor of Cellvizio®, the multidisciplinary confocal laser ... milestone in the US with the 12 th ... Drug Administration (FDA). This new FDA clearance covers ...
Breaking Medicine Technology: