Navigation Links
Stroke drug kills bacteria that cause ulcers and tuberculosis
Date:12/20/2012

Bethesda, MDA drug currently being used to treat ischemic strokes may prove to be a significant advance in the treatment of tuberculosis and ulcers. In a new research report appearing online in The FASEB Journal, a compound called ebselen effectively inhibits the thioredoxin reductase system in a wide variety of bacteria, including Helicobacter pylori which causes gastric ulcers and Mycobacterium tuberculosis which causes tuberculosis. Thioredoxin and thioredoxin reductase proteins are essential for bacteria to make new DNA, and protect them against oxidative stress caused by the immune system. Targeting this system with ebselen, and others compounds like it, represents a new approach toward eradicating these bacteria.

"This new antibacterial principle provides better chances of surviving an infection," said Arne Holmgren, M.D., Ph.D., a researcher involved in the work from the Division of Biochemistry in the Department of Medical Biochemistry and Biophysics, at Karolinska Institutet in Stockholm, Sweden. "Since ebselen is also an antioxidant, the present mechanism can be described as a 'two for the price of one' antioxidant action in inflammation, and specific targeting of multi-resistant bacterial complications and sepsis."

Building on previous observations where ebselen has shown antibacterial properties against some bacteria, Holmgren and colleagues hypothesized that the bacteria sensitive to ebselen relied solely on thioredoxin and thioredoxin reductase for essential cellular processes. They investigated this by testing it on strains of E. coli with deletions in the genes for thioredoxin, thioredoxin reductase and the glutaredoxin system. They found that strains with deletions in the genes coding for glutaredoxin system were much more sensitive than normal bacteria. Researchers further tested ebselen against Helicobacter pylori and Mycobacterium tuberculosis, which both naturally lack the glutaredoxin system and are frequently resistant to many commonly used antibiotics, and found both to be sensitive to ebselen.

"As rapidly as these organisms evolve, we need new drugs sooner rather than later," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "The fact that these scientists have found a new target for killing some of the most resistant bacteria is great news, but the fact that we already have at least one drug which we could possibly use now makes the news even better."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. UGA research offers new targets for stroke treatments
2. US Drug Watchdog Now Urges Yaz Yasmin Birth Control Pill Users Who Suffered a Stroke, Blood Clots, or a Heart Attack to Call the Johnson Law Group for a Legal Review
3. Neurological Wellness Center's Novel Neuro-Inflammation Inhibition Procedure that Induces Rapid Recovery from Alzheimer's, Stroke and Brain Injury is Now Being Taught in a Newly Released Video
4. Silent stroke can cause Parkinsons disease
5. Neurocritical Care & Stroke Conference slated for March 2013
6. Telestroke networks can be cost-effective for hospitals, good for patients
7. High Blood Pressure Poses Bigger Stroke Risk for Blacks, Study Says
8. Changes in the gut bacteria protect against stroke
9. Blau, Brown & Leonard, LLC Settlements Near Two Million Dollars on Behalf of Women who Endured DVT's, PE's and Strokes from Yaz, Yasmin and Ocella
10. Stress, Depression Linked to Raised Stroke Risk in Seniors
11. RSNA: New Study Finds Brain Angioplasty and Stents Safe and Effective for Stroke Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... CA (PRWEB) , ... January 24, 2017 , ... ... for 21st century leadership, has named Hector M. Chavez, Manager, Employee & Labor Relations ... treatment center - as its Hispanic Leader of the Month. City of Hope is ...
(Date:1/24/2017)... ... 24, 2017 , ... The University of Iowa, long recognized as one of ... program that provides teachers with the specific skills and training they need to teach ... for post-baccalaureate students and HigherEducation.com is working to ensure that this new program is ...
(Date:1/24/2017)... ... ... The NewKILO JRP, a three-year project of the European Metrology Research Programme ... was completed in May 2015. The future definition will require the unit of mass ... presents some challenges to establishing traceability to the mass scale. , This white ...
(Date:1/24/2017)... ... January 24, 2017 , ... Today, Taza Agua, Costa ... bottles, designed specifically to optimize the drinking experience for K-Cup coffee, tea and ... introducing the world’s first untouched bottled water purposed exclusively for creating a superior ...
(Date:1/24/2017)... ... January 24, 2017 , ... “Speaking With God’s Voice”: ... Voice” is the creation of published author, Louis A. Miraglia, a born-again believer, who ... to deliver God’s great, impactful Word. , “There is little doubt that God ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... , Jan. 24, 2017 Sherpa ... clinical materials management services, is pleased to announce ... Operations. Kevin joins the Sherpa team to lead ... highest level of service excellence. Kevin ... and pharmaceutical manufacturing industries. He has extensive experience ...
(Date:1/24/2017)... Pa. , Jan. 24, 2017   ... 2 biopharmaceutical company developing novel therapies for the ... today announced the appointment of four world-class key ... These new appointments join QR Pharma,s previous roster ... leadership and direction to support the development of ...
(Date:1/24/2017)... 2017 The global  active pharmaceutical ingredients (API) market ... based on a new report by Grand View Research, Inc. The rising ... the market over the forecast period. Advancements in recombinant molecular technologies and ... growth.  Continue Reading ... ...
Breaking Medicine Technology: