Navigation Links
Stroke damage in mice overcome by training that 'rewires' brain centers
Date:2/5/2013

udies showed that although many nerve cells in the primary motor cortex were permanently damaged by the stroke, a different part of the brain called the medial premotor cortex adapted to control reaching and grasping. Zeiler says the function of the medial premotor cortex is not well-understood, but in this case it seemed to take over the functions associated with the reach-and-grab task in his experimental mice.

The researchers also report that otherwise healthy mice trained to reach and grasp pellets did not lose this ability after experiencing a stroke in the medial premotor cortex, which suggests that this part of the brain typically plays no role in those activities, and the existence of untapped levels of brain plasticity might be exploited to help human stroke victims.

Zeiler says another key finding in his research team's mouse model was a reduction of the level of parvalbumin, a protein that marks the identity and activity of inhibitory neurons that keep the brain's circuitry from overloading. With lower levels of parvalbumin in the medial premotor cortex, it appears the "brakes" are essentially off, allowing for the kind of activity required to reorganize and rewire the brain to take on new functions in this case the ability to reach and grasp.

To prove that the learned functions had moved to the medial premotor cortex in the mice, the researchers induced strokes there. Again, the new skills were lost. And again, the mice could be retrained.

The research team's next steps with their mouse model include evaluating the effect of drugs and timing of physical rehab on long-term recovery. The research could offer insight into whether humans should receive earlier and more aggressive rehab.

"In people left with deficits after a stroke, we have been asking how we can encourage the rest of the nervous system to adapt to allow true recovery," Zeiler says. "This research begins to provide us some answers."


'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Predictors identified for rehospitalization among post-acute stroke patients
2. Could Menthol Cigarettes Pose Even Higher Stroke Risk?
3. NJ stroke researchers report advances in spatial neglect research at AAN Conference
4. Mobile Stroke Units Might Trim Time to Treatment
5. Spouses of Cancer Patients May Have Raised Risk of Heart Disease, Stroke
6. Stopping Blood Thinners Raises Stroke Risk for Patients With Irregular Heartbeat
7. Cedars-Sinai stroke team earns award for improving regions quality of care
8. Procedure gives patients with A-fib who cant take blood thinners alternative to reduce stroke
9. Irregular Heartbeat Poses Greater Stroke Risk for Women Than Men
10. Elderly women with irregular heart beat at higher risk for stroke
11. Rate of Hospitalizations for Stroke Has Declined in U.S.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... May 21, 2013 Patients of Dr. Michael ... have lost teeth due to gum disease and would like ... gum disease treatment with laser gum surgery. Gum ... the highest success rate out of all tooth replacement options. ... a relatively new procedure cleared by the Food and Drug ...
(Date:5/21/2013)... 2013 ContinuCare Home Health, Inc. recently ... Aging and Disability Services. After completing a four-day review ... ContinuCare Home Health was found to have no deficiencies ... of the Department of Aging and Disability Services’ mission ... services, supports and opportunities that are easily accessed ...
(Date:5/21/2013)... May 2013, Paris, France: One-year results from SOURCE XT ... implantation (TAVI) registries to-date reported today at EuroPCR ... with high rates of device success for all access ... XT Post-Approval Study followed up 2688 consecutively enrolled patients ... XT heart valve at 93 centres in 17 countries ...
(Date:5/21/2013)... The In View series , ... cable channels across the country, announces it has posted ... The producers of the series proudly bring audiences across ... the manufacturing industry, health-related companies, medical facilities and more. ... practitioners in all parts of the United States, Canada ...
(Date:5/21/2013)... May 21, 2013 Modern couples ... help of Texas Counseling’s Sexuality and Relationship Workshops, ... the development of healthier habits for their relationship. ... for both couples and individuals at Texas Counseling. ... relationships and learn skills to develop long term ...
Breaking Medicine News(10 mins):Health News:Shenk Dental Care Stimulates Bone Growth for Gum Disease Patients Seeking Dental Implants with Laser Gum Surgery in Atlanta, GA 2Health News:ContinuCare Home Health, Inc. Receives Perfect Report from the Texas Department of Aging and Disability Services 2Health News:In View hosted by Larry King Announces New Videos on its YouTube Channel 2Health News:Workshops Offered To Identify Underlying Challenges That Put Strain On Relationships 2
... CLEMENS, Mich., Nov. 25 Two more H1N1 vaccine clinics have ... Macomb County Health Department announced today. They are being offered at ... in Sterling Heights. , The Dec. 3 clinic will be held ... from 9 a.m. to 3 p.m. The thimerosol-free version of the ...
... Fla., Nov. 25 Daniel Touizer, CEO of Ci n ... guaranteed issue health insurance benefit programs, is concerned that the labor department,s recently ... job and unlikely to have health insurance. , "True unemployment ... highest rate in over 20 years," says Dani e ...
... and Spanish . Researchers from the ... ocular diseases that are very common today, such as age-related macular ... had never before been used for this purpose. Scientists from ... affected by one of these two pathologies, finding a greater amount ...
... available in French . Montreal, November 25, ... marketplace, thanks to a new partnership between Gestion Univalor, ... privately owned technology company based in Montreal. Univalor, ... its affiliated institutions, and CSI have announced the signature ...
... Discovery in fruit fly study may lead to new drugs ... -- Sphingadienes, natural lipid molecules found in soy, could become ... have found. , The findings are preliminary, but the ... soy seems to provide protection against colon cancer. , In ...
... experts offer waistline-friendly ways to enjoy festive feasting , WEDNESDAY, ... holiday smorgasbord from Thanksgiving to New Year,s, but are already ... come Jan. 1, help is at hand. , It,s possible, ... make it to 2010 weighing the same as you do ...
Cached Medicine News:Health News:Macomb County Health Department Schedules Two More H1N1 Flu Vaccine Clinics Dec. 3 and 5 2Health News:Cinergy Health Commentary on Health Care for the Unemployed 2Health News:Achieve early diagnosis of ocular pathologies such as keratitis and macular degeneration 2Health News:Univalor and Cognitive Sensing Inc. to commercialize 4 University of Montreal discoveries 2Health News:Natural Soy Component May Help Treat Colon Cancer 2Health News:Holiday Eating Without the Guilt -- or the Pounds 2Health News:Holiday Eating Without the Guilt -- or the Pounds 3
(Date:5/21/2013)... 2013   Regulus Therapeutics Inc . ( NASDAQ: ... development of innovative medicines targeting microRNAs, today announced that ... Operating Officer and Executive Vice President, Finance, will present ... Healthcare Conference on Wednesday, May 29, 2013 at 3:30 ... Westin Boston Waterfront Hotel. The presentation will ...
(Date:5/21/2013)... , May 21, 2013 On ... impressive new product developments at the Special Libraries Association PHTD ... of unerring focus on product literature databases and workflow solutions ... the occasion," said founding director Nigel Johnson ... of benefit to our clients and what better forum to ...
(Date:5/21/2013)... , May 21, 2013  Armada Health ... of the new Armada corporate website ( www.armadahealthcare.com ... communicate Armada,s unique and first-to-market services and its ... focused on the specialty pharmacy industry. ... of the Armada business model in delivering an ...
Breaking Medicine Technology:Regulus to Present at Deutsche Bank 38th Annual Healthcare Conference 2Pi2 Solutions' 10th Anniversary Heralds New Corporate Image as Platinum Sponsor of SLA PHT Meeting in Philadelphia 2Pi2 Solutions' 10th Anniversary Heralds New Corporate Image as Platinum Sponsor of SLA PHT Meeting in Philadelphia 3Armada Announces New Corporate Website to Showcase Expanded Services to Specialty Pharmacy Marketplace 2
... 2011 Onyx Pharmaceuticals, Inc. (NASDAQ: ... quarter 2011. Onyx reported a non-GAAP net loss of $14.2 ... 2011 compared to a non-GAAP net loss of $1.5 million, ... 2010. Non-GAAP net loss excludes, among other items, adjustments to ...
... 2011 Reportlinker.com announces that a new ... catalogue: Latin American Markets ... Guided Surgery 2011 (Argentina, Brazil and Mexico) ... In 2010, the total Latin American ...
Cached Medicine Technology:Onyx Pharmaceuticals Reports First Quarter 2011 Financial Results 2Onyx Pharmaceuticals Reports First Quarter 2011 Financial Results 3Onyx Pharmaceuticals Reports First Quarter 2011 Financial Results 4Onyx Pharmaceuticals Reports First Quarter 2011 Financial Results 5Onyx Pharmaceuticals Reports First Quarter 2011 Financial Results 6Onyx Pharmaceuticals Reports First Quarter 2011 Financial Results 7Onyx Pharmaceuticals Reports First Quarter 2011 Financial Results 8Onyx Pharmaceuticals Reports First Quarter 2011 Financial Results 9Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 2Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 3Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 4Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 5Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 6Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 7Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 8Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 9Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 10Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 11Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 12Reportlinker Adds Latin American Markets for Dental Implants, Final Abutments and Computer Guided Surgery 2011 (Argentina, Brazil and Mexico) 13
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: