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Stroke Undertreated
Date:1/22/2008

Patients May Not Be Offered Advanced Therapy

HOLLYWOOD, Fla., Jan. 22 /PRNewswire/ -- Stroke patients who fail the standard stroke treatment using clot-busting drugs may succeed with more advanced therapies that attack blood clots directly in the brain, according to data being presented at the 20th annual International Symposium on Endovascular Therapy (ISET).

"Often patients who fail to improve with standard intravenous (IV) stroke therapy aren't given the chance to succeed with more advanced intra-arterial (IA) therapy, because it's thought that it won't work if IV therapy didn't, and that it will increase the risk of bleeding in the brain," said Christopher Zylak, M.D., director of neurointerventional radiology at Sacred Heart Medical Center, Spokane, Wash. "Our data suggest that IA therapy can be highly successful even when IV therapy doesn't work, and that the risk of bleeding is no different between the two therapies."

Eighty-three percent of strokes are "ischemic," meaning they are caused by a small clot that blocks an artery in the brain, stopping blood flow, according to the American Stroke Association. (The remaining 17 percent of strokes are "hemorrhagic," and are caused by a leaking or ruptured blood vessel in the brain.) If the clot is not cleared and blood flow restored, permanent damage will result, such as paralysis or death. Stroke is the third leading cause of death in the United States, killing about 160,000 people a year, according to the National Stroke Association. About 750,000 people suffer from stroke annually.

Standard therapy at most hospital stroke centers involves placing an IV device in the patient's arm to administer clot-busting drugs, a percentage of which get to the site of the blockage in the brain that is causing the stroke. However, IV treatment must begin within three hours of the onset of stroke, meaning the patient must get to the hospital at the first signs of stroke.

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SOURCE International Symposium on Endovascular Therapy
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