Navigation Links
Stroke Treatment Window May Allow a Bit More Time
Date:10/20/2009

Drug given within 4.5 hours still benefits patients, study shows

TUESDAY, Oct. 20 (HealthDay News) -- Tissue plasminogen activator (tPA) treatment benefits stroke patients when used up to 4.5 hours after a stroke, according to German researchers who said their findings provide further evidence to increase the tPA treatment window from the current three hours to 4.5 hours.

Previously published findings from the ECASS III study indicated that tPA treatment led to better outcomes than placebo in stroke patients treated from three hours to 4.5 hours post-stroke.

In this new study, Dr. Werner Hacke, of the University of Heidelberg, and colleagues conducted a secondary analysis of ECASS III data using different endpoints. They focused on the efficacy and safety of tPA treatment (using alteplase) and also looked for any factors or patient subgroups that might affect treatment outcome.

The study included 418 patients who received alteplase from three hours to 4.5 hours after a stroke, and 403 patients who received a placebo. The results showed a clear benefit from treatment with alteplase in all types of patients, including those younger and older than 65 years, men and women, and those with or without a history of diabetes, stroke or high blood pressure.

The researchers also found that alteplase was beneficial, regardless of the severity of the stroke.

"Our results support the use of this thrombolytic drug in the extended period across a broad range of patient subgroups who meet the requirements of the European product label but miss the approved treatment window of 0-3 hours," Hacke and colleagues wrote. "Even with these encouraging findings, the most important principle of acute stroke intervention should, however, not be lost -- i.e., time remains critical and fast treatment still provides the greatest chance of recovery."

The study was released online Oct. 20 in advance of publication in the December print issue of The Lancet.

"Thrombolytic therapy benefits patients, should be given as early as possible, offers sustained benefit, and is cost-effective," Dr. Patrick Lyden, of Cedars-Sinai Medical Center in Los Angeles, wrote in an accompanying editorial.

"The physician must, as always, diligently undertake a careful history and physical examination, look at the non-contrast brain CT scan carefully, and follow the appropriate protocol. All of these steps will result in substantial benefit to public health and will safely benefit many patients. But 'time is brain,' and therapy must be given as soon as possible after the patient arrives -- there is indeed not a moment to lose."

More information

The American Heart Association has more about tPA.



-- Robert Preidt



SOURCE: The Lancet, news release, Oct. 20, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. High alcohol consumption increases stroke risk among Chinese men
3. Heavy Drinking Boosts Stroke Risk for Chinese Men
4. High alcohol consumption increases stroke risk, Tulane study says
5. Broad-based group of physicians calls for improvement in stroke treatment
6. Continued Statin Use Boosts Post-Stroke Outcomes
7. U.S. Initiative Seeks to Boost Hispanic Stroke Awareness
8. Stopping Statins After Stroke Doubles Death Risk
9. Can brain-injured, partially-blind stroke patients regain some of their lost vision?
10. REACH Registry Highlights That Patients With Peripheral Arterial Disease (PAD) Suffer High Rates of Heart Attack, Stroke, Hospitalization, and Death
11. Link Between Air Pollution, Stroke Gets Clearer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
(Date:6/24/2016)... ... , ... People across the U.S. are sharpening their pencils and honing their ... in which patients and their families pay tribute to a genetic counselor by nominating ... of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
Breaking Medicine Technology: