Navigation Links
Stroke Damage Is Less in Rats Given Opioids

Drugs induce a state of hibernation that improves recovery, study shows

WEDNESDAY, June 17 (HealthDay News) -- Hibernation induced by opioid drugs reduced brain damage and behavioral dysfunction in a study of rats that experienced an experimental stroke, researchers report.

"Studies in hibernating and active squirrels have shown that 'natural hibernation' has anti-ischemic effects," Cesar Borlongan, a neuroscientist at the University of South Florida Center for Aging and Brain Repair, said in a news release about the study. "We've shown that a drug that induces hibernation can achieve similar results."

Borlongan, along with colleagues at the U.S. National Institutes of Health, gave the rats a drug called [D-ala2,D-leU5] enkephalin (DADLE) -- which belongs to the same drug family as morphine and heroin -- and then induced a stroke in the rats by blocking cerebral artery blood flow.

After the stroke, the rats that received the drug did better on behavioral tests than rats that weren't given the drug before a stroke, the researchers found.

"DADLE prevented cell death processes and behavioral abnormalities," they wrote. "The observation that this substance, previously shown to induce hibernation, attenuated deficits inherent in cerebral ischemia provides a new pharmacological target for stroke therapy."

The study appears online in the journal BMC Biology.

More information

The National Stroke Association explains the effects of stroke.

-- Robert Preidt

SOURCE: BioMed Central, news release, June 16, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Psoriasis Raises Risk of Heart Attack, Stroke, Death
2. Mini-Stroke Can Mean Major One Within Hours
3. Sacred Heart Hospital Starts to Expose Students to Stroke Awareness at an Early Age
4. Minimally invasive stroke treatment produces better patient outcomes than surgical operation
5. Window for Stroke Treatment Opens Wider
6. Compression Stockings Offer Little Benefit After Stroke
7. Statins Can Help Prevent Second Stroke
8. Siemens Demonstrates Groundbreaking Approach to Stroke Diagnosis at ASNR 2009
9. Risk Factor for Stroke More Common Among Whites
10. Aspirin Lowers Stroke Risk in Peripheral Artery Disease
11. Seniors Often Misstate Stroke History
Post Your Comments:
Related Image:
Stroke Damage Is Less in Rats Given Opioids
(Date:10/13/2017)... Rock, AR (PRWEB) , ... October 13, 2017 ... ... firm with locations throughout Arkansas that offers insurance and financial preparation services, is ... benefit the Rock City Rescue organization. , Rock City Rescue is a locally ...
(Date:10/13/2017)... ... ... While it’s often important to take certain medications during the night, finding them ... a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX to provide ... need to turn on a light when taking medication during the night, allowing the ...
(Date:10/13/2017)... ... October 13, 2017 , ... The International Association of ... of excellence for the field of eating disorders, announces the opening of early ... in Orlando, Florida at the Omni Resort at ChampionsGate. , The ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with ... for the primary prevention of cardiovascular diseases during the 15th Annual Women’s ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... Sept. 22, 2017 AVACEN Medical (AVACEN) announced ... now successfully helping those with the widespread pain associated ... diagnosed Amanda in Essex, England ... my hair, experiencing no sleep at all, tremendous pain, ... I cannot recommend [the AVACEN 100] enough, how this ...
(Date:9/18/2017)... , Sept. 18, 2017 ... fields of bioinformatics and immune engineering, today ... protective avian influenza A (H7N9) vaccine. ... related to seasonal influenza and presents a ... on prior exposure to be effective. Using ...
(Date:9/12/2017)... SAN FRANCISCO , Sept. 12, 2017 /PRNewswire/ ... Lifecycle Management Solutions (VLMS), is pleased to announce ... as a member of its Board of Directors ... 2017. ValGenesis VLMS enables life science companies to ... eliminate the use of paper in this process. ...
Breaking Medicine Technology: