Navigation Links
Stroke Damage Is Less in Rats Given Opioids
Date:6/17/2009

Drugs induce a state of hibernation that improves recovery, study shows

WEDNESDAY, June 17 (HealthDay News) -- Hibernation induced by opioid drugs reduced brain damage and behavioral dysfunction in a study of rats that experienced an experimental stroke, researchers report.

"Studies in hibernating and active squirrels have shown that 'natural hibernation' has anti-ischemic effects," Cesar Borlongan, a neuroscientist at the University of South Florida Center for Aging and Brain Repair, said in a news release about the study. "We've shown that a drug that induces hibernation can achieve similar results."

Borlongan, along with colleagues at the U.S. National Institutes of Health, gave the rats a drug called [D-ala2,D-leU5] enkephalin (DADLE) -- which belongs to the same drug family as morphine and heroin -- and then induced a stroke in the rats by blocking cerebral artery blood flow.

After the stroke, the rats that received the drug did better on behavioral tests than rats that weren't given the drug before a stroke, the researchers found.

"DADLE prevented cell death processes and behavioral abnormalities," they wrote. "The observation that this substance, previously shown to induce hibernation, attenuated deficits inherent in cerebral ischemia provides a new pharmacological target for stroke therapy."

The study appears online in the journal BMC Biology.

More information

The National Stroke Association explains the effects of stroke.



-- Robert Preidt



SOURCE: BioMed Central, news release, June 16, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Psoriasis Raises Risk of Heart Attack, Stroke, Death
2. Mini-Stroke Can Mean Major One Within Hours
3. Sacred Heart Hospital Starts to Expose Students to Stroke Awareness at an Early Age
4. Minimally invasive stroke treatment produces better patient outcomes than surgical operation
5. Window for Stroke Treatment Opens Wider
6. Compression Stockings Offer Little Benefit After Stroke
7. Statins Can Help Prevent Second Stroke
8. Siemens Demonstrates Groundbreaking Approach to Stroke Diagnosis at ASNR 2009
9. Risk Factor for Stroke More Common Among Whites
10. Aspirin Lowers Stroke Risk in Peripheral Artery Disease
11. Seniors Often Misstate Stroke History
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stroke Damage Is Less in Rats Given Opioids
(Date:8/22/2017)... ... 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5-star rating to Energy NADH, ... stress of modern life continually makes more demands on time and energy, people are ... trap people in vicious high/low cycles and can also cause long term health issues. ...
(Date:8/21/2017)... ... August 22, 2017 , ... Nanoparticle research provides ... and safety. By learning and implementing best practices for containment using ventilated safety ... attendees will gain a better understanding of a method for safely testing nanotechnology ...
(Date:8/21/2017)... MINNEAPOLIS, MINN (PRWEB) , ... August 21, 2017 ... ... Sports Group, today announced that it has become the Official Technology Partner of ... their AES (Advanced Event Systems) volleyball software, along with providing sport ...
(Date:8/21/2017)... , ... August 21, 2017 , ... The experts have ... are we supposed to get things done in a healthy way these days? FlexiSpot, ... launching a crowdfunding campaign on August 28 to introduce Deskcise Pro™– the world’s first ...
(Date:8/21/2017)... CA (PRWEB) , ... August 21, 2017 , ... ... health services business of UnitedHealth Group (NYSE: UNH), has made a multi-million dollar ... responders affected by post-traumatic stress disorder (PTSD) and traumatic brain injuries (TBI) over ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... 3, 2017  Opioid addiction and other drugs of ... costs and threatening outcomes, were problems taken on directly ... industry that support them, met this week. This according ... that drugs of abuse, procalcitonin and acute kidney injury ... organization,s 69th meeting in San Diego, CA. ...
(Date:8/2/2017)... , Aug. 2, 2017 CaryRx, a next-generation ... day delivery service for patients in the Washington ... traditional retail pharmacy by providing delivery of medications through the ... for future delivery or delivered within one hour to any ... are excited to bring this invaluable service to ...
(Date:7/31/2017)... 31, 2017 7D Surgical, developer of ground breaking ... the 7D Surgical System to support its strategic sales plan ... and Virginia.  7D Surgical has entered into an ... the premier medical facilities within those markets. ... Spartan ...
Breaking Medicine Technology: