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Strides Made in Lung Cancer Treatment
Date:1/13/2010

red at the conference.

  • UCLA researchers report that a set of 40 biomarkers in the blood correctly identified patients with lung cancer and patients without lung cancer the vast majority of the time (88 percent and 79 percent, respectively). "Most of the biomarkers had to do with inflammation and other kinds of immunomodulatory approaches," explained Dr. Matthew Meyerson, a professor of pathology at Harvard Medical School. "This is not intended yet for clinical testing but it shows the potential power of serum-based profiling for early detection of lung cancer." Early detection, of course, is the key to recovery.
  • A panel of 93 genes indicating the presence of EGFR mutations in non-small cell lung cancer (the most common type of lung cancer) predicted which patients have a better prognosis and could benefit from drugs targeting this pathway, scientists from M.D. Anderson Cancer Center at the University of Texas found. "This set of gene expression changes can be useful in determining which patients harbor such mutations which might be sensitive to targeted therapies directed at that particular mutation," said Tyler Jacks, AACR president and director of the David H. Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology in Boston.
  • University of Colorado investigators found that patients with non-small cell lung cancer who also had certain configurations of the anaplastic lymphoma kinase (ALK) gene responded better to a new drug which inhibits activity of this gene. About a quarter of patients who took the drug saw their tumors shrink by 20 percent or more, said Dr. Paul A. Bunn Jr., IASLC executive director and the James Dudley chair in cancer research at the University of Colorado. "Some had complete dissolution of the tumor so it couldn't be seen any more. That almost never happens with chemo," he noted. Participants had received multiple other treatments before enrolling in the trial.'/>"/>

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