Navigation Links
Strides Made in Hemophilia Research
Date:6/16/2009

Successful blood-clotting in lab could pave way for human trials, researchers say

TUESDAY, June 16 (HealthDay News) -- Researchers studying the bleeding disease hemophilia in mice have increased the rodents' ability to produce a crucial blood-clotting protein, a new study says. Their success may pave the way for human trials.

Past studies have successfully introduced a gene into animals' cells to make the clotting protein, Factor VIII, which is missing in people with hemophilia. But attempts at gene therapy in humans have been disappointing, the study authors note.

In the new study, the researchers say they have developed an approach to target genes in mouse liver sinusoidal endothelial cells, which are the main source of Factor VIII.

Researchers hope the new approach will be a step toward successful human clinical trials in individuals with hemophilia A, the most common form of the inherited disorder.

The study by researchers from the University of Minnesota Medical School in Minneapolis is in the June issue of the Journal of Clinical Investigation.

In the study, researchers used nanoparticles coated with hyaluron to target liver sinusoidal endothelial cells. The nanoparticles contained a therapeutic gene (Factor VIII) as well as Sleeping Beauty, a genetic element that helps the therapeutic gene become inserted into the genome of the targeted cells.

Fifty weeks after the treatment, mice injected with these nanoparticles had Factor VIII levels that were the same as those of normal mice. Bleeding times were also similar to those of normal mice.

According to a news release from the journal, it is the authors hope that the combination of Sleeping Beauty and the cell-specific nanocapsule delivery system will result in a successful gene therapy.

More information

The National Heart, Lung and Blood Institute has more on hemophilia.



-- Jennifer Thomas



SOURCE: Journal of Clinical Investigation, news release, June 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Twenty-Five Individuals Honored by Yoplait(R) for Making Extraordinary Strides in the Fight Against Breast Cancer
2. GREAT STRIDES Walks for Cystic Fibrosis Slated for 47 States This Weekend
3. Gentiva Safe Strides(R) Home Balance Therapy Program is Reducing Risk of Dangerous Falls and Relieving Pain for Thousands of Older Americans
4. Stroller Strides(R) Franchises Succeed Despite Economic Climate
5. Stroller Strides(R) Signs Pampers(R) as Premier Sponsor for 2009
6. Womans Day Presents the Sixth Annual Red Dress Awards Honoring Women Making Strides in the Fight Against Heart Disease
7. Cystic Fibrosis Foundation Launches GREAT STRIDES Walks Nationwide at 600 Locations
8. Nektar Announces Agreement With Baxter to Develop New PEGylated Therapeutics for Hemophilia
9. Transplanted Liver Lining Cells May Cure Hemophilia
10. Wyeths XYNTHA Approved by FDA for Treatment of Hemophilia A
11. eWorld Companies, Inc. Establishes Strategic Alliance With Hemophilia Foundation of Southern California
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Strides Made in Hemophilia Research
(Date:8/16/2017)... ... August 16, 2017 , ... Paul Vitenas, MD, FACS , ... Top Doctor. The annual list identifies the nation’s top physicians, in a variety of ... it to the top of Castle Connolly’s coveted ranking. , Castle Connolly is the ...
(Date:8/16/2017)... ... August 16, 2017 , ... SGNA Standards of Infection ... reprocessing cycle, both between patient procedures and before storage, is a requisite practice ... important to the prevention of disease transmission and nosocomial infection as cleaning and ...
(Date:8/16/2017)... ... 16, 2017 , ... Richard Strawn’s new book Surgical ... of a cancer diagnosis, surgery and recovery, the Psalms provided encouragement and hope, ... God shows love to those who are sick., Surgical Psalms contains 36 reflections ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... an opportunity for men and women to train as hospice volunteers. Volunteers provide ... life-limiting illness. For over 30 years, the agency has trained volunteers to be ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... and marketers of high-quality anti-aging skincare solutions, recently announced the launch of two ... are an affordable, yet effective alternative to expensive plastic surgery or in-patient cosmetic ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... OCEANSIDE, Calif. , Aug. 15, 2017  AOTI Inc. announced ... Advanced Oxygen Therapy Inc., has recently opened a New York City ... the ever-increasing usage of its unique Topical Wound Oxygen (TWO 2 ... approved by the Accreditation Commission for Health Care (ACHC) under the ... ...
(Date:8/8/2017)... Second-quarter 2017 revenues of $876 million ... continuing operations Second-quarter 2017 ... million Second-quarter 2017 Sterile ... Second-quarter 2017 adjusted diluted earnings ... to $0.93 Second-quarter 2017 ...
(Date:8/7/2017)... , Aug. 7, 2017  Endo International plc (NASDAQ: ... agreements to resolve virtually all known U.S. mesh product ... to resolve the known remaining U.S. claims at reasonable ... beginning in the fourth quarter of 2017 and continuing ... its second quarter 2017 results, the Company intends to ...
Breaking Medicine Technology: