Navigation Links
Stress triggers tumor formation, Yale researchers find
Date:1/13/2010

This release is available in Chinese.

Stress induces signals that cause cells to develop into tumors, Yale researchers have discovered. The research, published online Jan. 13 in the journal Nature, describes a novel way cancer takes hold in the body and suggests new ways to attack the deadly disease.

Until now, most researchers believed that more than one cancer-causing mutation needed to take place in a single cell in order for tumors to grow. The Yale team, led by Tian Xu, professor and vice chairman of genetics and a Howard Hughes Medical Institute Investigator, illustrated that cancer-causing mutations can cooperate to promote tumor development even when they are located in different cells within a tissue.

"The bad news is that it is much easier for a tissue to accumulate mutations in different cells than in the same cell," said Tian, who also is a researcher with the Yale Cancer Center and the Fudan-Yale Center for Biomedical Research at Fudan University in China.

The Yale team worked with fruit flies to study the activity of two genes known to be involved in development of human cancers: a gene called RAS that has been implicated in 30 percent of cancers, and a tumor-suppressing gene called scribble, which contributes to tumor development when mutated. Neither a mutated RAS nor the defective scribble alone can cause cancer. Researchers in the Xu lab previously showed that a combination of the two within the same cell could trigger malignant tumors.

However, the Yale team found that these mutations did not have to co-exist in the same cell to cause tumors. A cell with only mutant RAS can develop into a malignant tumor if helped by a nearby cell with defective scribble. They also found stress conditions such as a wound could trigger cancer formation. For instance, RAS cells developed into tumors when a wound was induced
'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stress on Cells Can Turn Them Cancerous
2. Men, Women Respond to Stress Differently
3. Study Finds More Than One Third of Parents Experience Traumatic Stress One Month After Childs Injury
4. As Swine Flu Ebbs, Officials Stress Importance of Vaccine
5. Quitline messages that stress benefits of quitting may improve smoking cessation
6. Dont Invite Holiday Stress Into Your Home
7. Prescription Audio Gives the Gift of Stress Relief This Holiday Season
8. Dancing in the Eye of the Hurricane: How to Stop Running from Stress…and Start Asking It to Dance
9. Stress From Prostate Cancer Diagnosis May Be Fatal
10. How to Attack Holiday Stress Head-On
11. The Breema Center Presents a Yearlong Campaign to Transform Stress into Harmony in 2010 and Beyond
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... ... ... Olive Fertility Centre is proud to announce that Olive medical director Dr. Jason ... department of Family Practice. , “This award is a real honour,” says Dr Hitkari. ... changing so rapidly and we are also developing new models of patient-centred care that ...
(Date:7/6/2015)... SAN DIEGO, CA (PRWEB) , ... July 06, 2015 , ... ... , will deliver the keynote address at the 4th Annual Seedstock Sustainable Agriculture Conference ... , This year’s conference , held at the University of California-San Diego, will ...
(Date:7/6/2015)... ... 06, 2015 , ... With a new community program in the Livonia, Canton ... and announced a new charity campaign to raise funds in support of the health ... Livonia Save Our Youth is a coalition created especially to educate and empower teens, ...
(Date:7/6/2015)... ... 06, 2015 , ... Orthopaedic & Spine Center ( http://www.OSC-Ortho.com ... SpineFrontier’s® PedFuse® REmind® Screws. The operation took place on Tuesday, June 30, 2015 ... an L5-S1 posterior lumbar interbody fusion on a 69 year old, male patient. ...
(Date:7/5/2015)... ... ... City Sports, the Boston-based specialty sporting goods retailer, has renewed their partnership ... this summer with ethos, the owner and operator of the Boston Triathlon. , The ... at the North End Greenway. The event will help new triathletes prepare for the ...
Breaking Medicine News(10 mins):Health News:Olive Fertility Centre Physician Honoured for Teaching 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 3Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 4Health News:Bowker Insurance Group and Nonprofit Livonia Save Our Youth Initiate New Charity Campaign in Livonia, MI to Provide for The Health and Safety of The Communities’ Youth 2Health News:Bowker Insurance Group and Nonprofit Livonia Save Our Youth Initiate New Charity Campaign in Livonia, MI to Provide for The Health and Safety of The Communities’ Youth 3Health News:100th Outpatient Less Exposure Surgery Procedure Completed by Industry Leading Surgeon Dr. Jeffrey Carlson 2Health News:100th Outpatient Less Exposure Surgery Procedure Completed by Industry Leading Surgeon Dr. Jeffrey Carlson 3Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 2Health News:Sporting Goods Retailer City Sports Renews Partnership with Boston Triathlon 3
... American Botanical Council (ABC) has officially launched its Adopt-an-Herb ... tea ( Camellia sinensis ). For the next three ... to ensure that abstracts (summaries) of the latest published ... within ABC,s HerbMedPro database, one of the most robust ...
... American Life League will feature two of the most ... and Activism Week and Personhood Conference Jan. 21-23. , ... , , The TAW will ... launched the Born Alive Truth campaign during the 2008 presidential ...
... third of patients with suspect scans develop the disease within ... -- Among people whose brain scans show signs of multiple ... within about five years, researchers say. , The study ... variety of reasons, including migraines or head trauma. The scans ...
... , Company Appoints Tami Booth Corwin To New Position ... NEW YORK, Dec. 10 In its first major offline ... publisher of self-improvement books and products, to publish THE SPARK: ... Your Life. The book will give readers a proven ...
... racing to develop drugs that use the gene silencing mechanism ... Now, a new study opens up an entirely new possibility ... have demonstrated for the first time that RNA interference can ... , "Our data suggest that, at least in an ...
... Pharmaceuticals, Inc. ("Napo"),is pleased to announce a collaboration ... crofelemer for all indications in North America,Europe (excluding ... Crofelemer is Napo,s novel anti-secretory,gastrointestinal agent currently ... treatment of,chronic diarrhea in people living with HIV/AIDS ...
Cached Medicine News:Health News:Tea Dragon Films is First Adopter in the American Botanical Council's New Adopt-An-Herb Program 2Health News:Tea Dragon Films is First Adopter in the American Botanical Council's New Adopt-An-Herb Program 3Health News:Tea Dragon Films is First Adopter in the American Botanical Council's New Adopt-An-Herb Program 4Health News:A.L.L. Personhood Conference Features Pro-Life New Media Stars 2Health News:MRI Can Spot Presymptomatic MS 2Health News:Top Online Health & Lifestyle Media Brand Inks Major Book Deal 2Health News:Top Online Health & Lifestyle Media Brand Inks Major Book Deal 3Health News:Study first to show that RNA interference can facilitate vaccine development 2Health News:Study first to show that RNA interference can facilitate vaccine development 3Health News:Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals 2Health News:Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals 3Health News:Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals 4Health News:Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals 5
(Date:7/6/2015)... July 6, 2015 Increase ... drive bioinformatics market in Germany ... released TechSci Research report, " Germany Bioinformatics Market Forecast ... Germany is projected to register a CAGR ... to witness tremendous growth on account of rising government ...
(Date:7/6/2015)... 6, 2015 Hologic, Inc. (NASDAQ: HOLX ... its financial results for the third quarter of fiscal ... closes.  In conjunction with the release, management will host ... Time. Interested participants may listen to the ... States ) or 719-325-4804 (for international callers) and ...
(Date:7/6/2015)... 2015 Moerae Matrix, a clinical stage ... target inflammation and fibrosis, today announced the appointment ... Chief Medical Officer. Dr. Bradford ... programs, which include a pipeline of therapies for ... Bill is an accomplished strategist and scientist with ...
Breaking Medicine Technology:Germany Bioinformatics Market to Grow at a CAGR Over 29% Through 2020 Says TechSci Research 2Germany Bioinformatics Market to Grow at a CAGR Over 29% Through 2020 Says TechSci Research 3Hologic to Announce Financial Results for the Third Quarter of Fiscal 2015 on Wednesday, July 29, 2015 2Moerae Matrix, Inc. (Moerae) Appoints Bill Bradford, M.D., PhD, as Chief Medical Officer 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: