Navigation Links
Stress-induced changes in brain circuitry linked to cocaine relapse
Date:10/30/2009

Stress-evoked changes in circuits that regulate serotonin in certain parts of the brain can precipitate a low mood and a relapse in cocaine-seeking, based on mouse studies published online this week in the Proceedings of the National Academy of Sciences.

"The impetus for this research was our interest in how stress alters the brain's cell receptors and protein signals in ways that lead to mood changes, depression, anxiety, and drug seeking," said Dr. Michael Bruchas, acting instructor of pharmacology at the University of Washington (UW), who with Dr. Benjamin Land, a former UW doctoral student now in the Department of Psychiatry at Yale University, co-led the recent study of the adverse effects of stress-activated brain pathways. The senior author was Dr. Charles Chavkin, the Allan and Phyllis Treuer Professor of Pharmacology and director of the UW Center for Drug Addiction Research

A common belief is that drug seeking is regulated by dopamine, a chemical nerve signal associated with motivating and rewarding behavior. Dopamine may still have a key role, the researchers noted, which is why they were surprised to find harmful effects of stress converging in a brain region the dorsal raphe nucleus --where nerve cells that use serotonin are abundant. These nerve cells also project to other structures found on either side of the brain -- the nucleus accumbens -- which are thought to play roles in feeding and drug addiction. Serotonin is a chemical nerve signal that has been associated with wake and sleep cycles, mood, anger, status and aggression

In explaining their study, the researchers said that the dynorphin/kappa opioid system, found in certain brain cells, can be activated either through repeated stress or by giving a chemical that triggers a receptor on the cells. Activation of this system produces what is called conditioned place aversion in mice. They avoid smells, locations or tactile sensations similar to those present du
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Arbios Announces Management Changes
2. Renovis Announces Management Changes
3. Bradmer announces management changes
4. Streamline Health Announces Executive Management Changes
5. Onyx Pharmaceuticals Announces Management Changes
6. How pitching changes little leaguers shoulders
7. Sontra Medical Corporation Changes Name to Echo Therapeutics, Inc.
8. Medicare Changes Didnt Alter Cancer Care
9. Breaking Study: Masimo Pleth Variability Index (PVI) Shown Effective in Noninvasive Detection of Changes in Ventricular Preload and Fluid Volume
10. HealthShares(TM) Announces Changes to the HealthShares(TM) Diagnostics and Composite Indexes
11. Imaging shows structural changes in mild traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... today became a founding partner in the Global STEM ... promoting young talent in science, technology, engineering and math ... York Academy of Sciences (NYAS), Malaysian Prime Minister Najib ... Sept. 22. , With the goal of developing over ... by 2020, the initiative will create a host of ...
(Date:9/22/2014)... -- Recent two-generation approaches to reducing poverty that ... attention from researchers, advocates, and foundations. By combining ... to move to jobs that offer a path ... education for children, these programs aim to improve ... to a new report from the National Center ...
(Date:9/22/2014)... New York (PRWEB) September 22, 2014 ... with the use of power morcellators ( http://www.gynecaremorcellatorlawsuit.com/ ... notes a new report detailing the continued use ... from federal regulators that specifically discouraged these procedures. ... believe that the potential cancer risks associated with ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 Pain does not ... Pain” is a user- and reader-friendly book designed to guide ... to pain-free living. This inspirational book is written to help ... to know a way to regain a pain-free life — ... of chronic pain. , Chronic pain has become an epidemic, ...
(Date:9/22/2014)... 2014) Montefiore Medical Center, Albert Einstein College of Medicine ... received a $300,000 grant from The Agency for Healthcare ... health Information Technology (IT) on patient safety. , This ... important clinical patient safety issue impacted by health IT. ... first time IT leaders have data on the risk ...
Breaking Medicine News(10 mins):Health News:Growing scientists: World's future jobs are rooted in STEM 2Health News:Growing scientists: World's future jobs are rooted in STEM 3Health News:A two-generation lens: Current state policies fail to support families with young children 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes New Report Detailing Continued Use of Uterine Morcellation Despite FDA Warning 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes New Report Detailing Continued Use of Uterine Morcellation Despite FDA Warning 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes New Report Detailing Continued Use of Uterine Morcellation Despite FDA Warning 4Health News:Naturopathic Doctor Inspires and Guides Those Who Suffer with Chronic Pain, Pointing the Way Back to Pain-free Living 2Health News:AHRQ grant awarded to study the impact of health IT on patient safety at Montefiore and Einstein and Brigham and Women's Hospital 2
... 23 NxStage Medical, Inc.,(Nasdaq: NXTM ), a ... million private placement of its common stock and,warrants. The ... stock at a price of $4.50 per share and ... an exercise price of $5.50 per share,which price may ...
... 23 Dr. Nancy Minshew, a,leading researcher on the ... work in a presentation co-sponsored by the Pennsylvania,Cyber Charter ... diagnosed with autism. Students with,autism and other special needs ... its mission, is committed to focusing on the needs ...
... University,Medical Center (MUMC) now offers a type of ... the belly button. It,s called single,incision laparoscopic surgery, ... in the SILS technique. One of them is ... remove the gallbladder through a,1cm. incision in the ...
... MDNG, a publication that,reaches nearly a quarter ... discussion that will provide physicians an opportunity,to speak ... unique,practice model has made him a household name. ... 2008, at 8:00 p.m. EDT at, http://www.mdnglive.com/chat/JayParkinson ., ...
... 500,000 to make a world of difference for Singer Songwriter Katie ... Reider Beginning ... years, Cincinnati-based,singer songwriter Katie Reider, age 29, has inspired the hearts ... within. Fans across the country are banding together to help Katie,during ...
... ... health in the Western world, the, Omega-3 story may someday be viewed ... - William S. Harris, PhD, American ... Nutrition (2003), COLUMBUS, Ohio, May 23 If anyone needed another reason,to ...
Cached Medicine News:Health News:NxStage Announces $43 Million Private Placement of Equity Securities 2Health News:NxStage Announces $43 Million Private Placement of Equity Securities 3Health News:NxStage Announces $43 Million Private Placement of Equity Securities 4Health News:Dr. Nancy Minshew, Autism Researcher, to Speak at Regional Learning Alliance in Cranberry Township 2Health News:SILS Surgical Technique Now Available at MUMC 2Health News:MDNG Offers Free Online Discussion With Maverick Physician Jay Parkinson, M.D. 2Health News:Katie Reider - Listen to Her Songs, Hear Her Story, Log Onto www.500kin365.org 2Health News:Katie Reider - Listen to Her Songs, Hear Her Story, Log Onto www.500kin365.org 3Health News:Announcing Another Great Reason to Eat Chocolate 2
(Date:9/22/2014)... NEW YORK , September 22, 2014 ... New Market Report on "Global Market Study on Ophthalmic ... Growth by 2020," the global ophthalmic devices market was valued at ... grow at a CAGR of 6.5% from 2014 to ... million in 2020. Browse the full Global Market ...
(Date:9/22/2014)... , Sept. 22, 2014  AVT, Inc. (OTC ... retailing systems and custom vending machines, announced today that ... Unit. This new, smaller sized unit is designed for ... practices. According to industry statistics, there are ... Opticwash is the world,s first automated kiosk ...
(Date:9/22/2014)... GERMANTOWN, Md. , Sept. 22, 2014  Neuralstem, Inc. ... , MD, site investigator at Emory University, presented long-term ... NSI-566 human neural stem cells in the treatment of ... disease).  The presentation, which occurred at the Annual Symposium ... Montreal, Canada , on Friday, and was not ...
Breaking Medicine Technology:Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 2Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 3Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 4Global Ophthalmic Devices Market will Reach $2,685.1 Million in 2020: Persistence Market Research 5Opticwash Pro Enables Optical Retailers to Generate New Revenues and Customer Traffic through a Unique Eyeglass Cleaning System 2Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 2Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 3Neuralstem ALS Investigator Presents Long-Term Follow Up Phase I Data 4
... 2011 BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ) ... will present a company update at the Wedbush Life Sciences ... 10:00 a.m. ET. Interested parties may access a ... section of the BioMarin website, www.BMRN.com .  A replay ...
... 2011 Healthy Advice ® Networks, the ... engagement programs at point-of-care, announces that their partner, ... promote the Food and Drug Administration,s campaign, educating ... pain relievers. Partnering with MediaForce PR, Healthy ...
Cached Medicine Technology:BioMarin to Present at the Wedbush Life Sciences Conference 2Healthy Advice® Networks Partners With MediaForce PR to Deliver Public Service Announcements to Educate Consumers About Appropriate Use of Prescription Medications 2Healthy Advice® Networks Partners With MediaForce PR to Deliver Public Service Announcements to Educate Consumers About Appropriate Use of Prescription Medications 3
... Aplicare's Prep-Swab Ampule is a ... plastic tube that is sealed ... an absorbent applicator at the ... is squeezed to break the ...
... a valuable tool in standardizing protocols for ... for a procedure are supplied in a ... care are easier to be established and ... use, allowing the clinician to progress efficiently ...
... Patient preoperative skin preparation ... surgical site infections. Scrub Care ... trays offer high efficacy and ... , Prevail-Fx offers the highest ...
... Anti-HCV Low Titer Performance Panel consists of ... to strong positive for antibodies to the ... for use by manufacturers and diagnostic laboratories ... from all major test systems are included ...
Medicine Products: