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Stress hormone elevation is associated with working memory deficits in aging
Date:6/17/2014

"Thus, stress may act as a pacemaker of aging in this key brain region."

Older rats with higher levels of stress hormone displayed a 20 percent reduction in the density of dendritic spines (the small protrusions on neurons that come into close contact with other cells to form synapses, the connections between cells) relative to age-matched rats with less stress hormone.

The researchers also compared how the young and old rats performed on a simple working memory task, where the animals had to remember which arm of a two-arm maze contained a food reward following varying periods of delay. Older animals with higher levels of corticosterone made more errors when attempting to predict the location of the reward than age-matched animals with less of the stress hormone after a brief period of delay.

"These findings are not meant to indicate that high stress hormones are the only factor in determining the decline of mental abilities during aging," Radley cautioned. "Nonetheless, this study suggests that the effects of these stress hormones on the brain may be much more widespread than we previously thought."


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Contact: Emily Ortman
media@sfn.org
202-962-4090
Society for Neuroscience
Source:Eurekalert

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