Navigation Links
Stress hormone elevation is associated with working memory deficits in aging
Date:6/17/2014

Washington, DC A new study published in the June 18 issue of The Journal of Neuroscience adds to a body of evidence suggesting stress may accelerate cognitive decline later in life. The study found that aged rats with high levels of the stress hormone corticosterone showed structural changes in the brain and short-term memory deficits.

While most people will experience some cognitive decline as they get older, the extent of these changes and how rapidly they progress varies greatly from one person to the next. Scientists are interested in understanding the factors that contribute to these differences. Research suggests that how the body responds to stress may be one of the factors influencing how the brain ages. Multiple animal studies have linked high levels of the stress hormone corticosterone (similar to the human stress hormone cortisol) with age-related structural and functional decline in the hippocampus, a region that plays a key role in long-term memory.

Jason J. Radley of the University of Iowa wanted to know whether exposure to high levels of corticosterone is associated with other changes in the brain and memory deficits. In the current study, he and others measured the amount of the stress hormone in the blood of young and old rats and examined cells in the prefrontal cortex, a region of the brain involved in short-term memory. The researchers found that older animals with high levels of the stress hormone had fewer connections between prefrontal cortex cells than the older animals with lower levels of the hormone. In contrast, prefrontal cortex cells appeared similar in younger animals regardless of stress hormone levels.

"Older animals with higher levels of stress hormones in their blood have 'older' frontal cortexes than animals with less stress hormones," explained Stanford University professor Robert Sapolsky, PhD, an expert on the damaging effects of long-term stress who was not involved with this study. "Thus, stress may act as a pacemaker of aging in this key brain region."

Older rats with higher levels of stress hormone displayed a 20 percent reduction in the density of dendritic spines (the small protrusions on neurons that come into close contact with other cells to form synapses, the connections between cells) relative to age-matched rats with less stress hormone.

The researchers also compared how the young and old rats performed on a simple working memory task, where the animals had to remember which arm of a two-arm maze contained a food reward following varying periods of delay. Older animals with higher levels of corticosterone made more errors when attempting to predict the location of the reward than age-matched animals with less of the stress hormone after a brief period of delay.

"These findings are not meant to indicate that high stress hormones are the only factor in determining the decline of mental abilities during aging," Radley cautioned. "Nonetheless, this study suggests that the effects of these stress hormones on the brain may be much more widespread than we previously thought."


'/>"/>

Contact: Emily Ortman
media@sfn.org
202-962-4090
Society for Neuroscience
Source:Eurekalert

Related medicine news :

1. No long-term anxiety or distress associated with low-dose computed tomography screening
2. Stress hormone receptors localized in sweet taste cells
3. Ice Storm Project and maternal stress
4. Stress degrades sperm quality
5. Cognitive behavioral or relaxation training helps women reduce distress during breast cancer treatment
6. How does stress increase your risk for stroke and heart attack?
7. Stress research in therapy dogs reveals animals needs
8. Life stressors trigger neurological disorders, researchers find
9. Acute respiratory distress syndrome: Study IDs surgical patients at risk
10. Returning vets face warring identities distress
11. Yoga regulates stress hormones and improves quality of life for women with breast cancer undergoing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... (PRWEB) , ... January 17, 2017 , ... Gym Source, ... of a new showroom at South Dixie Hwy in Miami, FL. , “We are ... Gym Source. “The new innovative in-store concept is designed to give clients a seamless ...
(Date:1/17/2017)... Los Angeles, CA (PRWEB) , ... January 17, ... ... conflicted and concerned by the political/social/economic events, Dr. Carol Francis re-releases powerfully uplifting ... tragedies and magical moments that help everyone endure and pass through tough times, ...
(Date:1/17/2017)... ... January 17, 2017 , ... Kevin Harrington (one of the original Sharks ... DRTV campaigns regarding the topic of Beauty and Personal Care. , ... What better way to commit to these changes than beginning with personal care and ...
(Date:1/17/2017)... ... January 17, 2017 , ... Achieve TMS West, with multiple ... new office in San Clemente, California this month. Achieve TMS West is the ... treating individuals struggling with major depression. Depression impacts over 15 million adults in ...
(Date:1/17/2017)... ... January 17, 2017 , ... Peoples Health is pleased to ... on Dec. 1, 2016. Peoples Health, a Metairie-based Medicare Advantage company, serves more ... addition to our provider network, and the addition will benefit our members in ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... -- Research and Markets has announced the addition of ... to their offering. ... The global fluoropolymer market in the healthcare industry to grow ... Global Fluoropolymer Market in the Healthcare Industry 2016-2020, has been ... experts. The report covers the market landscape and its growth prospects ...
(Date:1/17/2017)... Tocagen Inc ., a clinical-stage, cancer-selective gene therapy company, today announced ... pharmaceutical development at Tocagen, will present at Phacilitate Cell & ... Miami . Details of the ... ... - what to do when and why Date and Time: Wednesday, ...
(Date:1/17/2017)... 2017 Research and Markets has announced the ... Generic), Manufacturer (Captive, Merchant), Synthesis (Synthetic, Biotech), Product (mAb, Hormone) Drug ... 2021" report to their offering. ... The global active pharmaceutical ingredients market is ... Billion in 2016, growing at a CAGR of 6.3% from 2016 ...
Breaking Medicine Technology: