Navigation Links
Stress hormone elevation is associated with working memory deficits in aging
Date:6/17/2014

Washington, DC A new study published in the June 18 issue of The Journal of Neuroscience adds to a body of evidence suggesting stress may accelerate cognitive decline later in life. The study found that aged rats with high levels of the stress hormone corticosterone showed structural changes in the brain and short-term memory deficits.

While most people will experience some cognitive decline as they get older, the extent of these changes and how rapidly they progress varies greatly from one person to the next. Scientists are interested in understanding the factors that contribute to these differences. Research suggests that how the body responds to stress may be one of the factors influencing how the brain ages. Multiple animal studies have linked high levels of the stress hormone corticosterone (similar to the human stress hormone cortisol) with age-related structural and functional decline in the hippocampus, a region that plays a key role in long-term memory.

Jason J. Radley of the University of Iowa wanted to know whether exposure to high levels of corticosterone is associated with other changes in the brain and memory deficits. In the current study, he and others measured the amount of the stress hormone in the blood of young and old rats and examined cells in the prefrontal cortex, a region of the brain involved in short-term memory. The researchers found that older animals with high levels of the stress hormone had fewer connections between prefrontal cortex cells than the older animals with lower levels of the hormone. In contrast, prefrontal cortex cells appeared similar in younger animals regardless of stress hormone levels.

"Older animals with higher levels of stress hormones in their blood have 'older' frontal cortexes than animals with less stress hormones," explained Stanford University professor Robert Sapolsky, PhD, an expert on the damaging effects of long-term stress who was not involved with this study. "Thus, stress may act as a pacemaker of aging in this key brain region."

Older rats with higher levels of stress hormone displayed a 20 percent reduction in the density of dendritic spines (the small protrusions on neurons that come into close contact with other cells to form synapses, the connections between cells) relative to age-matched rats with less stress hormone.

The researchers also compared how the young and old rats performed on a simple working memory task, where the animals had to remember which arm of a two-arm maze contained a food reward following varying periods of delay. Older animals with higher levels of corticosterone made more errors when attempting to predict the location of the reward than age-matched animals with less of the stress hormone after a brief period of delay.

"These findings are not meant to indicate that high stress hormones are the only factor in determining the decline of mental abilities during aging," Radley cautioned. "Nonetheless, this study suggests that the effects of these stress hormones on the brain may be much more widespread than we previously thought."


'/>"/>

Contact: Emily Ortman
media@sfn.org
202-962-4090
Society for Neuroscience
Source:Eurekalert

Related medicine news :

1. No long-term anxiety or distress associated with low-dose computed tomography screening
2. Stress hormone receptors localized in sweet taste cells
3. Ice Storm Project and maternal stress
4. Stress degrades sperm quality
5. Cognitive behavioral or relaxation training helps women reduce distress during breast cancer treatment
6. How does stress increase your risk for stroke and heart attack?
7. Stress research in therapy dogs reveals animals needs
8. Life stressors trigger neurological disorders, researchers find
9. Acute respiratory distress syndrome: Study IDs surgical patients at risk
10. Returning vets face warring identities distress
11. Yoga regulates stress hormones and improves quality of life for women with breast cancer undergoing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... February 06, 2016 , ... Shark Finds ... the launch of a new DRTV campaign with Belly Bands. , Having a dog ... from sprays to puppy pads and find nothing works, get Belly Bands, the ...
(Date:2/5/2016)... NY (PRWEB) , ... February 05, 2016 , ... Love ... long-stem roses in a variety of colors, assortments and packaging. This staple for Valentine’s ... any King Kullen location. , For Valentine’s Day, not only are long-stem roses ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... the stage for new clinical and scientific initiatives have all marked the last ... was appointed President and CEO of the nation’s oldest cancer center, Candace S. ...
(Date:2/5/2016)... ... February 05, 2016 , ... Francisco Canales, MD and Heather ... Napa Valley office. The technique utilizes the body’s own healing abilities to quickly ... Furnas, are part of only a select few cosmetic surgeons bringing this procedure ...
(Date:2/5/2016)... ... 05, 2016 , ... After years as an active staff surgeon and having ... surgeon Dr. Wayne Carman transitioned to chief of the Division of Plastic Surgery at ... term as chief and began a second three-year term in January of 2016. , ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... Feb. 5, 2016  Patients in Alabama ... ultrasound (HIFU) therapy no longer have to travel out of ... partnership with Urology Centers of Alabama to provide ... procedure for qualifying patients. Alabama ... the treatment of prostate cancer using many different modalities. They ...
(Date:2/5/2016)... VENICE, Fla. , Feb. 5, 2016 /PRNewswire/ ... Centers , is the first of its kind ... of undesired tattoos through advanced laser treatment. The ... Florida,s Suncoast by storm with ... video consultations, and advanced multi-wavelength Astanza Trinity technology. ...
(Date:2/5/2016)... , February 5, 2016 ... new market research report "Fetal (Labor & Delivery) and ... Antepartum), Warmer, Incubator, Pulse Oximeter, Phototherapy/Jaundice Management Devices, CPAP, ... by MarketsandMarkets, This report studies the global market over ... is estimated at USD 6.28 Billion in 2015 and ...
Breaking Medicine Technology: