Navigation Links
Stress during pregnancy leads to abdominal obesity in mice offspring
Date:7/31/2012

A new report involving mice suggests that a relationship exists between maternal metabolic or psychological stress and the development of obesity, type 2 diabetes, and metabolic syndrome in her offspring. What's more, the report shows that if the stress cannot be reduced or eliminated, manipulating the neuropeptide Y (NPY) system in visceral fat may prevent maternal stress-induced obesity from occurring in the next generation. This discovery is reported in the August 2012 issue of The FASEB Journal (http://www.fasebj.org).

"Obesity is a worldwide disease. Here we found that maternal stress, psychologically and metabolically, increases abdominal obesity and glucose intolerance in the next generation in a sex-specific manner, which is mediated by the NPY system in visceral fat," said Ruijun Han, a researcher involved in the work from the Department of Integrative Biology and Physiology, Stress Physiology Center at the University of Minnesota. "Our study suggested that NPY in the platelet-rich plasma and its Y2 receptor in the visceral fat, play an important role in maternal stress-programmed abdominal obesity and metabolic syndrome in offspring."

To make this discovery, Young and colleagues fed different groups of pregnant mice a low protein diet during pregnancy and lactation; a normal protein diet during pregnancy and lactation; or a low protein diet only during pregnancy. After weaning, all the pups were fed high fat diets for 18 weeks, and metabolic parameters and expression of NPY system in periphery tissues were monitored and measured.

"There are a lot of reasons why expectant mothers should not be under stress," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, "and this report adds yet another reason. What's most interesting, however, is that it provides some insight into how we can counter the negative effects of stress, even when it's not possible to reduce or eliminate the stressors themselves."


'/>"/>
Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Force of habit: Stress hormones switch off areas of the brain for goal-directed behaviour
2. Yoga reduces stress; now its known why
3. Male Ontario students show declines in fighting; females show elevated bullying and mental distress
4. Stressful Jobs Linked to Heart Woes in Women
5. Does Stress Management Slow MS?
6. Police officer stress creates significant health risks, study finds
7. New Health Product: Adaptogen Blend by Longevity Herbs May Help the Body Cope With Stress
8. Poor Sleep Affects Immune System Much Like Physical Stress
9. Sleep deprivation effect on the immune system mirrors physical stress
10. Link between brain insulin resistance, neuronal stress in worsening Alzheimers disease
11. Hospitals communication during residency matching may put stress on OB-GYN doctors-in-training
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... San Francisco, CA (PRWEB) , ... February 27, ... ... transplant clinic serving San Francisco and environs, is proud to announce an upgrade ... research information on the upgraded Yelp page on topics as diverse as Platelet ...
(Date:2/26/2017)... ... February 26, 2017 , ... Today, A' Design Awards & ... International Social Design Awards. , The 7th A' Social Design Award is ... Institutions worldwide with realized projects and conceptual works. , The first phase of ...
(Date:2/26/2017)... ... February 26, 2017 , ... LatitudeC Baby Products, an ... announced it would be offering some it’s exclusive product line to the public ... and unique baby clothing/feeding products, will team up with AMAZON to distribute a ...
(Date:2/26/2017)... ... February 26, 2017 , ... ODH, Inc.™ announced today it will exhibit ... Sheraton Pentagon City Hotel in Arlington, VA. ODH’s director of medical strategy, Candace Saldarini, ... to improve Medicaid population health management. , ODH will also have an exhibit booth ...
(Date:2/25/2017)... ... February 25, 2017 , ... FCPX users now have the ... Pixel Film Studios. With ProSharpen Color users have total control over sharpening amount, sharpening ... color range. With color spectrum tools users can visually see the color range effected ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... NORWALK, Conn. , Feb. 27, 2017 /PRNewswire/ ... a meta-analysis of 28 studies, representing 2468 patients ... disease (GERD). The study entitled, " Systematic Review ... Studies of Endoscopic Radiofrequency for Treatment of Gastroesophageal ... . Authors included Ronnie Fass , MD, ...
(Date:2/27/2017)... Israel and TAMPA, Fla. , Feb. ... emerging medical device company focused on developing cerebral ... applauds the members of the FDA,s Circulatory System ... their acknowledgement of the need for cerebral protection ... "The statements shared by this FDA panel ...
(Date:2/27/2017)... (NASDAQ: IPXL ) today announced that it plans to participate ... James and Associates, 38 th Annual Institutional Investors Conference at ... Cowen and Company 37 th Annual ... Boston, MA. Barclays Global Healthcare ... FL. Individuals may listen to the ...
Breaking Medicine Technology: