Navigation Links
Stress Robs Skin of Antimicrobial Defenses
Date:11/2/2007

Researchers discover how it leads to 'nervous breakdown' in the epidermis

FRIDAY, Nov. 2 (Health Day News) -- A team of researchers has identified the biological mechanism by which stress increases susceptibility to skin infections.

"We have shown what stress does, the basis of the stress," said study author Dr. Peter Elias, a professor of dermatology at the University of California, San Francisco, and the VA Medical Center, San Francisco. Interestingly, it has nothing to do with the classic explanation of the immune system breaking down, he added.

Rather, it's a breakdown in the skin's antimicrobial defense, according to the study in the November issue of The Journal of Clinical Investigation.

Elias and his team subjected mice to psychological stress and found them more susceptible to group A Streptococcus pyogenes skin infections than mice kept under less stressful conditions.

The stressed-out mice showed a decrease in the expression of antimicrobial peptides by the skin's epidermis.

Streptococcal bacteria can cause many problems, such as skin infections, severe sore throats and even flesh-eating disease. The role of the peptides that Elias and his team studied have come to light in recent years, and it has been found that they are the "front line" of the immune system. They act like antibiotics, attacking bacteria and killing them.

In the study, Elias' team also found that the stress led to the increased production of glucocorticoids. This, in turn, inhibited the synthesis of fat in the skin's epidermis and reduced the secretion of vesicles containing antimicrobial peptides, setting up the mice for skin problems.

"What happens is, stress down-regulates the expression of two key families of antimicrobial peptides," Elias said. As that happened, skin infections became more severe in the animals.

When Elias' team blocked the production of the glucocorticoids, the skin's antimicrobial defenses returned to normal.

While many people think of the immune system's T-cells, which attack invaders, as the first line of defense, recent research suggests otherwise, Elias said. ""The antimicrobial defense mechanisms are so effective, they deal with 99.5 percent of all challenges by microbial pathogens, such as bad viruses, bad bacteria," he said.

In an accompanying commentary, Dr. Andrzej Slominski, of the University of Tennessee, wrote that "this study provides what I believe to be the first mechanistic link between psychological stress and increased susceptibility to microbial infection."

The research may eventually lead to new treatment options, such as topical medications that block excess glucocorticoid production.

More information

To learn more about skin conditions, visit the U.S. National Library of Medicine.



SOURCES: Peter Elias, M.D., professor, dermatology, University of California, San Francisco, VA Medical Center, San Francisco; November 2007, The Journal of Clinical Investigation


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stress reduces your immunity- startling but true!!!!!
2. Meditation relieves stress
3. New guidelines for dealing with post traumatic stress disorder
4. Meditation relieves stress
5. Stress can make you overweight
6. Stress response increases suicide risk
7. Avoid stress to have strong babies
8. Toddlers stressed out
9. Spirituality relieves stress
10. Alcohol injures stress hormone response
11. Self control makes stress response easy
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stress Robs Skin of Antimicrobial Defenses
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, 2016 , ... ... the factors of a stroke, which we as a society can control and change. ... a stroke occurs nearly every 40 seconds within the United States. Plus, with an ...
(Date:5/27/2016)... ... ... Beleza Medspa has initiated a new program to assist active duty ... that Coolsculpting is being used for for more than just cosmetic purposes. ... prescribed body-fat standard, measured by the circumference-based tape method. The tape-test is used ...
(Date:5/27/2016)... ... 27, 2016 , ... Each year Standard Process Inc. ... is this year’s Life University winner of a $2,500 scholarship from ... Leadership Awards ceremony. , Outerbridge is approaching her last quarter at Life University ...
(Date:5/26/2016)... ... 2016 , ... There are many ways to cook a hot dog, but ... Americans prefer their dogs straight off the grill. Of the 90 percent of Americans ... to cook a hot dog, far outpacing other cooking methods such as steaming (12 ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... clinical outcomes, hosted members and suppliers for its inaugural Member Conference at the ... their mission of elevating the operational health of America’s healthcare providers. , The ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 ... aplicación médica para ayudar a los médicos a compartir ... los pacientes a escala mundial. Profesionales médicos de Europa, ... ya se han apuntado a la aplicación, que combina ... en un entorno totalmente seguro. Educación   ...
(Date:5/24/2016)... CHRISTCHURCH, New Zealand , May 24, 2016 ... scanning and informatics solutions for the healthcare sector, has been ... the New Zealand Hi-Tech Awards 2016. Dr ... a fantastic acknowledgement for our team.  It,s really good to ... the burden healthcare internationally. Our products are used in 35 ...
(Date:5/24/2016)... KONG , May 24, 2016 ... , the world , s first ... AV fistula intervention   OrbusNeich, a global ... has expanded its portfolio to include products to treat ... are the company,s first entry devices for lower limb ...
Breaking Medicine Technology: