Navigation Links
Stress May Speed Melanoma Progression
Date:2/19/2009

But certain heart drugs may help counter the effect, researchers say

THURSDAY, Feb. 19 (HealthDay News) -- Stress appears to hasten the progression of aggressive or advanced melanoma skin cancer, but commonly prescribed blood pressure drugs may slow the disease and improve the quality of patients' lives, according to an Ohio State University study.

In laboratory tests, the researchers exposed samples of three melanoma cell lines to the stress hormone norepinephrine and looked for changes in the levels of certain proteins released by the cells: vascular endothelial growth factor (VEGF), which stimulates the growth of new blood vessels to feed a growing tumor; and interleukin-6 (IL-6) and interleukin-8 (IL-8), which play a role in tumor growth.

When exposed to norepinephrine, all three melanoma cell lines increased production of the three proteins. In C8161 cells -- the most aggressive and advanced form of melanoma -- there was "a 2,000 percent increase in IL-6. In untreated samples from this cell line, you normally can't detect any IL-6 at all," Eric V. Yang, a research scientist at the Institute for Behavioral Medicine Research, said in an OSU news release.

"What this tells us is that stress might have a worse effect on melanoma that is in a very aggressive or advanced stage, and that one marker for that might be increased levels of IL-6," Yang said.

The researchers found that norepinephrine molecules bind to receptors on the surface of cancer cells, which stimulates the release of the pro-cancer proteins.

Further tests showed that common beta-blocker blood pressure drugs significantly reduced melanoma cells' production of IL-6 and the other two proteins. The drugs did this by blocking the receptors on the surface of the cancer cells.

The findings, published in the February issue of the journal Brain, Behavior and Immunity, suggest that beta-blockers may help slow the progression of melanoma, Yang and colleagues said.

Each year in the United States, almost 48,000 cases of melanoma are diagnosed and nearly 8,000 people die of the disease, according to the American Cancer Society.

More information

The American Academy of Dermatology has more about melanoma.



-- Robert Preidt



SOURCE: Ohio State University, news release, Jan. 30, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New research shows how chronic stress worsens neurodegenerative disease course
2. Ability to cope with stress can increase good cholesterol in older white men, study finds
3. Handling Stress Properly Increases Good Cholesterol
4. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
5. Stressed-Out Moms Carry Babies on the Right
6. New Asthma Guidelines Stress Disease Control
7. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
8. Study identifies key player in the bodys immune response to chronic stress
9. Environmental stress probed in cardiovascular disease, diabetes
10. Parents PTSD May Boost Stress in Offspring
11. New nurses report job stress, need for better management
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stress May Speed Melanoma Progression
(Date:6/23/2017)... ... June 23, 2017 , ... Yesterday, U.S. ... healthcare bill to repeal and replace the Affordable Care Act (ACA). Like the ... significant cuts to Medicaid, a public health insurance program for low-income children, pregnant ...
(Date:6/23/2017)... ... ... Everybody has their own personal preference when it comes to pornography. Some ... don't like it at all. FindaTopDoc took a look at what makes people attracted ... readers a taste of their deepest, darkest fantasies and has the ability to help ...
(Date:6/23/2017)... ... ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows ... civil society in 11 countries across the Middle East and South Asia to embark ... of knowledge and ideas with the leading minds in their fields. , For ...
(Date:6/23/2017)... Francisco, CA (PRWEB) , ... June 23, 2017 , ... ... on 26th June, 2017 from 9 am to 3 pm to present to graduate ... The program is an original curriculum project led by The Health Improvement Service ...
(Date:6/23/2017)... ... June 23, 2017 , ... Moore Insurance, ... area with access to asset protection and financial planning services, is teaming up ... improving the lives of children with cancer and other chronic diseases. , The ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... -- Novavax, Inc., (Nasdaq: NVAX ) today announced that ... its RSV F protein recombinant nanoparticle vaccine candidate (RSV F ... in the journal Vaccine (the data ... conferences). The Company previously announced top line results ... RSV F Vaccine with the goal of protecting infants from ...
(Date:6/3/2017)... INDIANAPOLIS , June 3, 2017  Eli ... today announced that results from the Phase 3 ... kinase (CDK)4 & 6 inhibitor, in combination with ... treatment with fulvestrant alone in women with hormone-receptor-positive ... advanced breast cancer who have relapsed or progressed ...
(Date:5/30/2017)... , May 30, 2017 Hill-Rom Holdings, Inc. (NYSE: ... Annual Global Healthcare Conference on Tuesday, June 13, 2017, in ... Greisch , Hill-Rom,s president and chief executive officer, is scheduled ... live audio webcast can be accessed at http://ir.hill-rom.com/events.cfm . ... of the live event through September 13, 2017. ...
Breaking Medicine Technology: