Navigation Links
Stress May Speed Melanoma Progression

But certain heart drugs may help counter the effect, researchers say

THURSDAY, Feb. 19 (HealthDay News) -- Stress appears to hasten the progression of aggressive or advanced melanoma skin cancer, but commonly prescribed blood pressure drugs may slow the disease and improve the quality of patients' lives, according to an Ohio State University study.

In laboratory tests, the researchers exposed samples of three melanoma cell lines to the stress hormone norepinephrine and looked for changes in the levels of certain proteins released by the cells: vascular endothelial growth factor (VEGF), which stimulates the growth of new blood vessels to feed a growing tumor; and interleukin-6 (IL-6) and interleukin-8 (IL-8), which play a role in tumor growth.

When exposed to norepinephrine, all three melanoma cell lines increased production of the three proteins. In C8161 cells -- the most aggressive and advanced form of melanoma -- there was "a 2,000 percent increase in IL-6. In untreated samples from this cell line, you normally can't detect any IL-6 at all," Eric V. Yang, a research scientist at the Institute for Behavioral Medicine Research, said in an OSU news release.

"What this tells us is that stress might have a worse effect on melanoma that is in a very aggressive or advanced stage, and that one marker for that might be increased levels of IL-6," Yang said.

The researchers found that norepinephrine molecules bind to receptors on the surface of cancer cells, which stimulates the release of the pro-cancer proteins.

Further tests showed that common beta-blocker blood pressure drugs significantly reduced melanoma cells' production of IL-6 and the other two proteins. The drugs did this by blocking the receptors on the surface of the cancer cells.

The findings, published in the February issue of the journal Brain, Behavior and Immunity, suggest that beta-blockers may help slow the progression of melanoma, Yang and colleagues said.

Each year in the United States, almost 48,000 cases of melanoma are diagnosed and nearly 8,000 people die of the disease, according to the American Cancer Society.

More information

The American Academy of Dermatology has more about melanoma.

-- Robert Preidt

SOURCE: Ohio State University, news release, Jan. 30, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New research shows how chronic stress worsens neurodegenerative disease course
2. Ability to cope with stress can increase good cholesterol in older white men, study finds
3. Handling Stress Properly Increases Good Cholesterol
4. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
5. Stressed-Out Moms Carry Babies on the Right
6. New Asthma Guidelines Stress Disease Control
7. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
8. Study identifies key player in the bodys immune response to chronic stress
9. Environmental stress probed in cardiovascular disease, diabetes
10. Parents PTSD May Boost Stress in Offspring
11. New nurses report job stress, need for better management
Post Your Comments:
Related Image:
Stress May Speed Melanoma Progression
(Date:11/29/2015)... ... November 29, 2015 , ... ProStatic Analog ... effect tool designed specially for Final Cut Pro X. FCPX users ... the easy-to-use modification controls. Destoying and creating chaotic distortion is now quick and ...
(Date:11/28/2015)... ... ... Trying to relax on a couch can actually be uncomfortable, so an ... due to personal experience with a bad back," he said. , This easy-to-use, versatile ... as increases support. It also makes it easier to eat, do other activities and ...
(Date:11/27/2015)... ... November 27, 2015 , ... According to an ... the University of Toronto and the University of British Columbia suggested that laws requiring ... injuries. The article explains that part of the reason for the controversial conclusion is ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... the toilets were," said an inventor from Hillside, N.J. "Many people catch diseases ... cover so that individuals will always be protected from germs." , He developed ...
(Date:11/27/2015)... ... November 27, 2015 , ... Consistent with the ... 2016 Building Better Radiology Marketing Programs meeting will showcase some of the ... 2016, at Caesars Palace in Las Vegas with a pre-conference session on a ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... UTRECHT , Nederland, November 26, 2015 ... --> Een nieuwe aanpak combineert ... van gevorderde kanker. ... -->      (Photo: ... van het Leids Universitair Medisch Centrum (LUMC) ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 /PRNewswire/ ... the addition of the "2016 Future ... Drugs of Abuse Testing Market: Supplier Shares, ... report to their offering. --> ... of the "2016 Future Horizons and ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Therapeutic Drug Monitoring (TDM) Market: Supplier ... Emerging Opportunities"  report to their offering.  ... announced the addition of the  "2016 ...
Breaking Medicine Technology: