Navigation Links
Stress May Encourage E. Coli Illness
Date:3/19/2009

Anxiety-linked hormones could spur the stomach bug's activity, research suggests

WEDNESDAY, March 18 (HealthDay News) -- Researchers say they have found a possible link between stress-induced sickness and a diarrhea-causing strain of the E. coli bacterium.

Researchers at the University of Texas Southwestern Medical Center say the newly discovered QseE receptor, found on the enterohemorrhagic Escherichia coli (EHEC) strain, picks up signals when stress hormones are released in the body. Once activated, this pathogen -- which usually enters the body through contaminated food such as raw meat -- sets off a series of reactions that release toxins into the body. This process changes the makeup of other cells and robs the body of nutrients.

"The bacteria get what they want -- nourishment -- and the person ends up getting diarrhea," study senior author Vanessa Sperandio, UT Southwestern associate professor of microbiology, said in a news release issued by the school.

QseE, which is found only in intestinal bacteria, works with the known previously found QseC sensor kinase (enzyme) on the EHEC bacterium. QseC, discovered by Sperandio's lab about three years ago, provides the timing for the bacterium's actions, including the regulation of the genes necessary for EHEC to cause diarrhea. It appears to have a key role in other disease development because its senses stress cues, mostly from body chemicals generally linked to blood poisoning, also known as sepsis.

"Patients with high levels of phosphate in the intestine have a much higher probability of developing sepsis due to systemic infection by intestinal bacteria," Sperandio said. "If we can find out how bacteria sense these cues, then we can try to interfere in the process and prevent infection."

The findings were published online March 10 and are scheduled to be published in a future print issue of the Proceedings of the National Academy of Sciences.

The human body usually hosts millions of potentially harmful bacteria that stay dormant until they receive a signal that it's to release their toxins. If those signals never arrive, the bacteria pass through the body without harm.

"There's obviously a lot of chemical signaling between host and bacteria going on, and we have very little information about which bacteria receptors recognize the host and vice-versa," Sperandio said. "We're scratching at the tip of the iceberg on our knowledge of this."

In previous research, Sperandio discovered that phentolamine, an alpha blocker used to treat high blood pressure, and a new drug called LED209, prevent QseC from doing its nasty work. Tests on whether phentolamine also works on QseE are expected to follow.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about bacteria and foodborne illness.



-- Kevin McKeever



SOURCE: University of Texas Southwestern Medical Center, news release, March 10, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New research shows how chronic stress worsens neurodegenerative disease course
2. Ability to cope with stress can increase good cholesterol in older white men, study finds
3. Handling Stress Properly Increases Good Cholesterol
4. New Alzheimers findings: High stress and genetic risk factor lead to increased memory decline
5. Stressed-Out Moms Carry Babies on the Right
6. New Asthma Guidelines Stress Disease Control
7. Latest DES Analysis Stresses Importance of Physicians Well-Trained in Implantation Technique and Patient Follow-Up
8. Study identifies key player in the bodys immune response to chronic stress
9. Environmental stress probed in cardiovascular disease, diabetes
10. Parents PTSD May Boost Stress in Offspring
11. New nurses report job stress, need for better management
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stress May Encourage E. Coli Illness
(Date:1/13/2017)... ... January 13, 2017 , ... KOAMTAC ®, Inc., a leading manufacturer ... next generation companion scanner and data collector at the National Retail Federation’s Big Show ... as an answer to the market’s need for more compact and rugged devices for ...
(Date:1/13/2017)... ... ... inventor from Pahrump, Nev., used an unsavory medical experience to think of a way to ... urine bag for a half year due to lazy bladder," he said. "Keeping these things ... better way to do this." , He then designed and created a prototype of the ...
(Date:1/13/2017)... Minneapolis, MN (PRWEB) , ... January 13, 2017 , ... ... have to endure jolts of pain whenever they brush their teeth. Sadly, most dental ... people who have sensitive gums and teeth. For these people, continuing their daily oral ...
(Date:1/13/2017)... (PRWEB) , ... January 13, 2017 , ... Friday, January ... area of the game room, increasing the size of the location to 90,000 square ... an 8-hole mini golf course that takes customers on an educational tour of the ...
(Date:1/13/2017)... ... 2017 , ... MyGenetx, a molecular laboratory headquartered in middle Tennessee is proud ... Smith, RD, LD, will serve on the 2017 TBCC Board. , Kris ... and one year as Vice President. She will oversee the newly elected board of ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... According to the new market research report "Display Controller Market by ... LCD Controller), Application (Industrial Control, Medical Equipment, Automotive, Mobile Communication), and Geography ... to grow from USD 17.26 Billion in 2015 to reach USD 32.24 ... Continue Reading ... ...
(Date:1/16/2017)... PORTLAND, Oregon and PUNE, India ... According to a new report published by Allied Market ... Global Opportunity Analysis and Industry Forecast, 2014-2022," the ... million by 2022, from $5,768 million in 2015, growing ... The chemical & gas sterilization segment dominated the market ...
(Date:1/16/2017)... , January 16, 2017 Transparency Market ... Smart Medical Devices Market  held a huge share of 43% ... have been frontrunners in the overall market, grabbing the undivided ... growing presence across geographies, and strong product portfolio is expected ... few years.  ...
Breaking Medicine Technology: