Navigation Links
Streptococci and E. coli continue to put newborns at risk for sepsis
Date:4/24/2011

Bloodstream infections in newborns can lead to serious complications with substantial morbidity and mortality. What's more, the pathogens responsible for neonatal infections have changed over time. In recent years, however, antibiotic prophylaxis given to at-risk mothers has reduced the incidence of early-onset group B streptococcal infections among their babies.

A new nationwide, multi-site study aimed at determining current early-onset sepsis rates among newborns, the pathogens involved, and associated morbidity and mortality demonstrates that the most frequent pathogens associated with sepsis are group B streptococci (GBS) in full-term infants and Escherichia coli in preterm infants.

The study, which included nearly 400,000 newborns, also found that infection rates in newborns increased with decreasing gestational age and birth weight. The overall rate of infection was 0.98 per 1,000 live births; 0.41 per 1,000 live births involving GBS and 0.28 per 1,000 live births involving E. coli.

The study appears online April 25 and in the May 2011 issue of Pediatrics.

GBS emerged as the leading cause of early-onset sepsis and meningitis in newborns in the 1970s. In 2002, the Centers for Disease Control and Prevention recommended universal screening of women at 35 to 37 weeks of pregnancy followed by chemoprophylaxis for women with GBS colonization.

Sepsis occurs when pathogenic bacteria enter the blood stream, causing systemic infection. In infants less than 72 hours old, sepsis is considered of early onset.

"Infections occur in almost one case per thousand live births," says Barbara Stoll, MD, lead investigator for the study. Stoll is the George W. Brumley, Jr., Professor and Chair, Department of Pediatrics in Emory University School of Medicine. "With approximately 4 million births a year in the United States, this equates to a substantial burden of disease. We estimate that approximately 3,000 infants a year develop early-onset sepsis. With current mortality rates, approximately 300 to 350 deaths per year are associated with neonatal sepsis. So, it's not inconsequential."

The study also shows that opportunities for prevention of neonatal GBS infections continue to be missed. "Missed opportunities for prevention of GBS include failure to screen all women who deliver at term, failure to provide antibiotics to all colonized women or to those who delivered preterm with unknown colonization status and false negative GBS screens among women who deliver with GBS infection," says Stoll.

"Our findings suggest that accurate point-of-care diagnostic tests at the time a woman comes in for delivery would enhance our ability to identify at-risk women."

In addition, the gap in linking electronic medical records between a woman's obstetrician and the hospital where she delivers can also impede prevention. "A community health record that links the medical record in a physician's office with the hospital where the woman gets care could enhance identification and therapy for at-risk women," says Stoll. "If a woman has been screened for GBS and is known to be colonized, that information should be available to the health care team taking care of her at the time she is in labor."


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Related medicine news :

1. More women medical students select general surgery and continue to close the gender gap
2. U.S. Cancer Rates Continue to Fall
3. Explosions Continue to Rock Japanese Nuclear Complex
4. Women who miscarry continue to have mental health problems
5. Need for Blood and Organ Donors Continues to Grow
6. Heavy Drinking in Teen Years May Continue Into Adulthood
7. Pollution controls used during China Olympics could save lives if continued
8. Race gap narrows for some cancers in African-Americans; continues to increase for others
9. Oncology basic research director at John Theurer Cancer Center continues transplantation research
10. Rep. Giffords Continues to Improve
11. Rep. Giffords Continues to Recover From Gunshot Wound
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... May 27, 2016 , ... An influential resource amongst nurses and professionals ... shed lights on the variety of topics detailing why we appreciate nurses in so ... this career has gone from being in a major recession to one of the ...
(Date:5/27/2016)... ... May 27, 2016 , ... An educational campaign aimed ... human-interest stories, courtesy of awareness-driven celebrities and thought leaders. It also provides insight ... and industry leaders such as Bioness. , As patients feel increasingly concerned ...
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses and ... interest stories, courtesy of leaders in the nursing and health care industry. It ... leading advocates and associations—namely Jones & Bartlett Learning. , Jones & Bartlett Learning ...
(Date:5/27/2016)... , ... May 27, 2016 , ... ... name in the pharmaceutical, medical and food industries. Aside from its GMP accreditation, ... (SIC), providing proof of successfully certified products, services and staff. , Validation Center ...
(Date:5/26/2016)... ... May 26, 2016 , ... W.S. Badger Co. Inc ., ... with a 2016 When Work Works Award for its use of effective workplace strategies ... When Work Works project administered by the Families and Work Institute (FWI) and the ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... 2016 According to the 2016 ... driving ambulatory blood pressure monitoring system market growth. With ... ability to respond to different pressure rates, leading to ... to various cardiovascular disorders such as heart failure, stroke, ... are growing in prevalence each year. WHO estimates that ...
(Date:5/27/2016)... May 27, 2016 The healthcare ... health insurance companies all falling under its umbrella.  A ... While not often talked about, these healthcare companies are ... States is by far the largest consumer ... Isotope Corp. (OTC: ADMD), Nutranomics Inc. (OTC: NNRX), KollagenX ...
(Date:5/26/2016)... NASHVILLE, Tenn. , May 26, 2016 ... provider of software and analytics, network solutions ... healthcare, today announced it entered into a ... leading provider of outpatient software solutions and ... surgery centers, specialty hospitals and rehabilitation clinics ...
Breaking Medicine Technology: