Navigation Links
Strep steps up in urinary tract infections

Research suggests pathogenic strains of Group B Streptococcus (GBS) are an under-recognised cause of urinary tract infections.

The bacteria are better known as a cause of infection in pregnant women with subsequent risks of preterm delivery and transmission to newborn infants often with devastating consequences.

Microbiologist Dr Glen Ulett, from the Griffith Institute for Health and Medical Research, said pathogenic strains of GBS have been shown to bind to the surface of human bladder cells as the initial step in the development of urinary tract infections.

"Affected cells appear to change their morphology and secrete significant amounts of interleukin, an inflammatory cytokine which activates the body's immune system."

He said the interleukin levels associated with GBS infection were significantly higher than those associated with Escherichia coli, the cause of 90 per cent of urinary tract infections. The findings have appeared in the Journal of Infectious Diseases.

"The fact that GBS causes more inflammation than E. coli was the exact opposite to what we expected and supports the notion that GBS urinary tract infection is unique and may cause disease at a lower bacterial count than is typical," Dr Ulett said.

He said because GBS is part of the normal microbial flora of the genital tract in about 40 per cent of healthy women, isolation of the bacteria in urine samples was often attributed to contamination of the sample rather than an possible indicator of disease.

"Because there are no clearly defined risk factors for GBS infection, the high prevalence of the bacteria, and the difficulties of diagnosis, we are probably often overlooking this organism as a cause of urinary tract infections."

Dr Ulett said a clinical study of over 34,000 patients published last year in collaboration with Westmead Hospital, University of Queensland and the University of Alabama, showed that non-typeable GBS serotypes were not associated with urinary tract infections as was previously thought.

"Importantly, we showed that GBS serotype III was the only serotype more commonly associated with urinary tract infections compared with other serotypes. This gives us a better understanding of the potential targets for vaccine development."

He said while a vaccine to protect women against GBS urinary tract infections may not be a priority on its own, it may be a spin-off benefit from the need to protect newborn infants against fulminating GBS infection through maternal vaccination.


Contact: Mardi Chapman
Research Australia

Related medicine news :

1. Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae
2. B. Eliot Cole, MD, Steps Down as Executive VP at Aventine Healthsciences and Executive Director of American Society of Pain Educators
3. Consumers over age 50 should consider steps to cut copper and iron intake
4. New York Medical Malpractice Attorney Recommends Cancer Patients Take Precautionary Steps Before Undergoing Radiation Therapy
5. KID HEALTHY-Steps to Healthy Living Kicks Off 2010 Campaign to Make Southern California Kids and Families Healthier
6. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
7. New Lumension Webcast Highlights Key Steps to Prepare Healthcare Firms and Business Associates to Comply with New HITECH Act
8. Doctors: Memorable or Forgettable? 4 Steps to a High Visibility Practice
9. Experts Push 7 Steps to Heart Health
10. IOM report recommends steps to tackle hepatitis B and C
11. Five Steps to Reaching 2010 Career Goals
Post Your Comments:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... locations throughout Arkansas that offers insurance and financial preparation services, is providing an ... Rock City Rescue organization. , Rock City Rescue is a locally recognized nonprofit ...
(Date:10/13/2017)... ... 13, 2017 , ... The International Association of Eating Disorders ... for the field of eating disorders, announces the opening of early registration for ... Florida at the Omni Resort at ChampionsGate. , The annual iaedp™ ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , which ... evacuation of the facility as part of a disaster drill on October 3rd. , ... and Shelton City Emergency Manager, as well as the Connecticut Long Term Care ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... WASHINGTON , Sept. 28, 2017 Cohen ... to advance the use of wearable and home sensors ... brain disorders. Early Signal Foundation, a nonprofit organization focused ... populations, will provide an affordable analytical system to record ... ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
(Date:9/22/2017)... Sept. 22, 2017  As the latest Obamacare repeal ... Bill Cassidy (R-LA) and Lindsey Graham ... the medical device industry is in an odd place. ... the 2.3% excise tax on medical device sales passed ... want covered patients, increased visits and hospital customers with ...
Breaking Medicine Technology: