Navigation Links
Strep steps up in urinary tract infections
Date:4/23/2010

Research suggests pathogenic strains of Group B Streptococcus (GBS) are an under-recognised cause of urinary tract infections.

The bacteria are better known as a cause of infection in pregnant women with subsequent risks of preterm delivery and transmission to newborn infants often with devastating consequences.

Microbiologist Dr Glen Ulett, from the Griffith Institute for Health and Medical Research, said pathogenic strains of GBS have been shown to bind to the surface of human bladder cells as the initial step in the development of urinary tract infections.

"Affected cells appear to change their morphology and secrete significant amounts of interleukin, an inflammatory cytokine which activates the body's immune system."

He said the interleukin levels associated with GBS infection were significantly higher than those associated with Escherichia coli, the cause of 90 per cent of urinary tract infections. The findings have appeared in the Journal of Infectious Diseases.

"The fact that GBS causes more inflammation than E. coli was the exact opposite to what we expected and supports the notion that GBS urinary tract infection is unique and may cause disease at a lower bacterial count than is typical," Dr Ulett said.

He said because GBS is part of the normal microbial flora of the genital tract in about 40 per cent of healthy women, isolation of the bacteria in urine samples was often attributed to contamination of the sample rather than an possible indicator of disease.

"Because there are no clearly defined risk factors for GBS infection, the high prevalence of the bacteria, and the difficulties of diagnosis, we are probably often overlooking this organism as a cause of urinary tract infections."

Dr Ulett said a clinical study of over 34,000 patients published last year in collaboration with Westmead Hospital, University of Queensland and the University of Alabama, showed that non-typeable GBS serotypes were not associated with urinary tract infections as was previously thought.

"Importantly, we showed that GBS serotype III was the only serotype more commonly associated with urinary tract infections compared with other serotypes. This gives us a better understanding of the potential targets for vaccine development."

He said while a vaccine to protect women against GBS urinary tract infections may not be a priority on its own, it may be a spin-off benefit from the need to protect newborn infants against fulminating GBS infection through maternal vaccination.


'/>"/>

Contact: Mardi Chapman
m.chapman@griffith.edu.au
61-755-529-089
Research Australia
Source:Eurekalert

Related medicine news :

1. Severity of H1N1 influenza linked to presence of Streptococcus pneumoniae
2. B. Eliot Cole, MD, Steps Down as Executive VP at Aventine Healthsciences and Executive Director of American Society of Pain Educators
3. Consumers over age 50 should consider steps to cut copper and iron intake
4. New York Medical Malpractice Attorney Recommends Cancer Patients Take Precautionary Steps Before Undergoing Radiation Therapy
5. KID HEALTHY-Steps to Healthy Living Kicks Off 2010 Campaign to Make Southern California Kids and Families Healthier
6. UAB-led study shows simple steps could reduce stillbirths by up to 1 million
7. New Lumension Webcast Highlights Key Steps to Prepare Healthcare Firms and Business Associates to Comply with New HITECH Act
8. Doctors: Memorable or Forgettable? 4 Steps to a High Visibility Practice
9. Experts Push 7 Steps to Heart Health
10. IOM report recommends steps to tackle hepatitis B and C
11. Five Steps to Reaching 2010 Career Goals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San ... Society and the Road To Recovery® program to drive cancer patients to and from ... adults to ensure the highest quality of life and ongoing independence. Getting to ...
(Date:6/24/2016)... Nevada (PRWEB) , ... June 24, 2016 , ... ... Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations ... in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Consumers have taken ... regulators/payers have placed more emphasis on patient outcomes. ... support programs in the pharmaceutical industry have evolved ... Consequently, pharmaceutical companies are focusing on becoming more ... providing products and services that improve health. ...
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
Breaking Medicine Technology: