Navigation Links
Strengthening fragile immune memories to fight chronic infections
Date:8/18/2011

After recovering from the flu or another acute infection, your immune system is ready to react quickly if you run into the same virus again. White blood cells called memory T cells develop during the infection and help the immune system remember the virus and attack it if it comes back.

But chronic infections such as those caused by viruses like HIV and hepatitis C are different. If the immune system can't clear the infection out of the body fast enough, the memory T cells that initially developed against the virus upon first encounter are lost. This poses a challenge for vaccine development.

Researchers at the Emory Vaccine Center have identified the conditions that make memory T cells slip away during persistent infections. They have also shown that a molecule called 2B4 on memory cells causes them to slow down during chronic infections. The results are published online this week in the journal Immunity.

The results have implications for vaccine design. The authors emphasize the importance of having vaccines that encourage the immune system to quickly control a potentially chronic infection or prevent it from gaining a foothold a task that some experimental vaccines against HIV's cousin SIV have accomplished.

"In a chronic infection, the memory T cells become so tightly regulated that they eventually are ineffective," says first author Erin West, an Emory graduate student in immunology and molecular pathogenesis. "This is why it's so important to have that initial strength at the beginning."

West and most of the co-authors are in the laboratory of Rafi Ahmed, PhD, director of the Emory Vaccine Center and a Georgia Research Alliance Eminent Scholar. Researchers from Harvard Medical School also contributed to the study, including W. Nicholas Haining and Cox Terhorst.

West and her colleagues studied mice infected by a meningitis virus which establishes a chronic infection. A weaker form of the virus can be c
'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Strengthening routine flu vaccination and health programs may improve pandemic vaccinations
2. Bone-Strengthening Drug Guards Against Spread of Breast Cancer
3. New clinical trial to examine medication to treat social withdrawal in Fragile X and autism
4. Fragile X researcher honored by March of Dimes
5. Study shows promise for new drug to treat Fragile X
6. U-M researchers discover way to block neurodegeneration in an adult form of Fragile X syndrome
7. Parents report a widely prescribed antibiotic is effective for fragile X treatment
8. UT Southwestern researchers uncover Fragile X syndrome genes role in shaping brain
9. Brain Develops Differently in Fragile X Syndrome
10. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
11. Penn researchers describe key molecule that keeps immune cell development on track
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Recently, TideStore.com, a leading online store offering many ... offer TideStore Thanksgiving Sales . According to the ... provided with big discounts. The special offer is valid ... extra 10% discount with this coupon code: thanks. , ... opportunities to win free gifts. TideStore.com has done much ...
(Date:11/21/2014)... CARE Surrogacy Center in Mexico is ... at the same time enhancing their surrogacy journey with high ... parents across the globe, the company is reporting on its ... zoning in on the skyrocketing costs of surrogacy — and ... over-stressing clinical success rates ? , Fertility clinics ...
(Date:11/21/2014)... TX (PRWEB) November 21, 2014 ... facility at 7am today. The new facility is located ... open 24-7. , “We are pleased to join ... highest quality emergency medical care here,” said Dr. Siddiqi, ... , To celebrate the opening, First Choice ...
(Date:11/21/2014)... Maureen Salamon HealthDay Reporter ... Jobs requiring intellectually challenging tasks may help preserve thinking ... suggests. The researchers compared IQ scores obtained ... with their memory and reasoning scores around age 70. ... jobs appeared to retain sharper thinking even years after ...
(Date:11/21/2014)... (HealthDay News) -- Some people with cochlear implants experience ... when they undergo an MRI scan, a new study ... researchers, about 300,000 people worldwide have cochlear implants, devices ... are deaf or have severe hearing loss. There have ... implants when undergoing MRI. One expert said the ...
Breaking Medicine News(10 mins):Health News:Thanksgiving Sales from TideStore.com 2Health News:CARE Surrogacy Center Reports on its Multiple Measures of Success 2Health News:CARE Surrogacy Center Reports on its Multiple Measures of Success 3Health News:First Choice Emergency Room Opens New Facility in Friendswood, Texas 2Health News:Could Your Job Help Preserve Your Aging Brain? 2Health News:Could Your Job Help Preserve Your Aging Brain? 3Health News:MRI Can Be Painful, Disruptive for People With Cochlear Implants 2
... brain, study suggests , , WEDNESDAY, Aug. 22 (HealthDay News) ... traumatic memories go so deep and linger so long ... shows that a powerful neurochemical called norepinephrine is released ... it also "imprints" an emotional fear tagged to the ...
... it prevented buildup of dangerous tau protein , , TUESDAY, ... combat a protein implicated in Alzheimer,s disease has proven ... protein accumulates into damaging tangles in the memory center ... at the New York University Medical Center (NYUMC). , ...
... , TUESDAY, Aug. 21 (HealthDay News) -- Claims of male-female ... or validation, experts report in the Aug. 22/29 issue of ... A team of researchers in Greece analyzed 77 studies that ... percent) of these claims were decided in advance of the ...
... three-quarters of cases went unnoticed, study found , , TUESDAY, ... one in four children who had high blood pressure ... the dangerous problem is missed. , "Hypertension in children ... a pediatrician, internist and fellow at the Center for ...
... major study finds , , TUESDAY, Aug. 21 (HealthDay News) -- ... cancer and acrylamide, a substance found in many baked and ... subject conducted to date. , "The data are accumulating, and ... to be an important breast cancer risk factor," said study ...
... the behavioral and academic problems associated with Attention Deficit ... by researchers at Lehigh Universitys College of Education. , ... National Institute of Mental Health (NIMH), was the largest ... 5 who have shown significant symptoms of ADHD. It ...
Cached Medicine News:Health News:Study Probes Roots of Fearful Memories 2Health News:Gene Studies of Male-Female Differences Often Flawed 2Health News:Doctors Often Miss High Blood Pressure in Kids 2Health News:Doctors Often Miss High Blood Pressure in Kids 3Health News:Acrylamide Won't Raise Breast Cancer Risk 2Health News:Acrylamide Won't Raise Breast Cancer Risk 3Health News:Acrylamide Won't Raise Breast Cancer Risk 4Health News:Non-medicinal treatment touted for pre-schoolers with ADHD 2Health News:Non-medicinal treatment touted for pre-schoolers with ADHD 3
(Date:11/21/2014)... Nov. 21, 2014  Lexicon Pharmaceuticals, Inc. (Nasdaq: ... its offering of $80,000,000 aggregate principal amount of 5.25% ... a private offering within the United States ... institutional buyers pursuant to Rule 144A under the Securities ... has also granted the initial purchasers an option to ...
(Date:11/18/2014)... 2014 Breast cancer will interrupt life ... who get a new diagnosis. The Commission for ... case managers to help those diagnosed with advanced ... physical, emotional and financial decisions that come with ... cost via the Commission,s online knowledge resource, the ...
(Date:11/18/2014)... , Nov. 18, 2014 BioLink ... International Technology Transfer Summit, co-organized by CCCMHPIE ( ... Export of Medicines & Health Products), UBM Live ... January 22nd and 23rd, 2015 at Beijing Yizhuang Biomedical ...   This event will gather ...
Breaking Medicine Technology:Lexicon Announces Pricing Of Convertible Senior Notes Offering 2Lexicon Announces Pricing Of Convertible Senior Notes Offering 3New Breast Cancer Resources: Commission For Case Manager Certification Adds Specialty Tools to Case Management Body of Knowledge Online Learning Center 2BioLink 2015 Will be Held on Jan 22, 2015, with a Focus on Biopharma Industrial Innovation & International Technology Transfer 2BioLink 2015 Will be Held on Jan 22, 2015, with a Focus on Biopharma Industrial Innovation & International Technology Transfer 3
... historic open letter to the World Health Organization ... Drugs (CoMeD) , and the United Methodist Women are seeking ... vaccines.  Currently, the mercury-based preservative Thimerosal, which is 49% mercury ... much of the world, despite the fact that it is ...
... Texas, March 15, 2012  OxySure® Systems, Inc. (OTCBB: ... emergency oxygen solutions with its "oxygen from powder" ... a Supplier Agreement ("Agreement") with W.W. Grainger, Inc. ... (Logo:  http://photos.prnewswire.com/prnh/20120315/DA71084LOGO ) In terms ...
Cached Medicine Technology:Global Call for Mercury-free Vaccines Issued 2OxySure Systems Announces Supplier Agreement With Grainger 2OxySure Systems Announces Supplier Agreement With Grainger 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: