Navigation Links
Strategy discovered to activate genes that suppress tumors and inhibit cancer
Date:5/21/2012

sor genes," said Wang. "So we theorized that by inhibiting the enzyme that this gene produces, the 'good guys' -- the tumor-suppressor genes -- would do a better job at destroying cancerous tissue and allowing the body to heal."

To test their theory, Wang and his colleagues treated mice that had cancerous tumors with a molecule to inhibit the PAD4 enzyme. They found that, especially when combined with additional enzyme inhibitors, the treatment worked as effectively as the most-commonly-used chemotherapy drug, doxorubicin, which shrinks tumors by about 70 percent.

Most striking, however, was that the PAD4 enzyme-inhibition strategy caused significantly less damage to healthy tissues. "Current chemotherapy drugs such as doxorubicin don't attack just tumors; unfortunately, they also attack healthy areas of the body," Wang explained. "That's why chemotherapy patients experience such terrible side effects such as weight loss, nausea, and hair loss. Because the PAD4 treatment appears to be less toxic, it could be an excellent alternative to current chemotherapy treatments."

Wang also explained that the PAD4 gene's dual personality -- on the one hand a helpful defense against bacteria, while on the other, a harmful silencer of cancer-suppressor genes -- can be understood from the perspectives of evolution and longer life spans. "Our ancestors didn't have antibiotics, so a bacterial infection could easily result in death, especially in young children," Wang explained. "So, back then, an overactive PAD4 gene was advantageous because the NET bacteria-trapping mechanism was the body's major defense against infection." Wang also explained that on the other hand, because people today have access to antibiotics, we live much longer than our ancestors did. "PAD4's bad effects -- cancer and autoimmune diseases -- tend to be illnesses that appear later in life," Wang said. "So nowadays, an overactive PAD4 gene, while still protective against bacteria, can
'/>"/>

Contact: Barbara Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Governor Rendell Proposes Budget With No Tax Increase, More Money for Public Schools, Strategy for Jobs, Plan to Address Future Deficits
2. SOKO Fitness & Spa Group Broadens Geographic Expansion Strategy
3. Keenan Chief Strategy Officer Selected to Join Editorial Board of Payers & Providers
4. Data Strategy Announces SurePath Services Offering for EMC Avamar
5. New strategy produces promising advance in cancer vaccines
6. New Cancer-Fighting Strategy Focuses On Signaling Molecules
7. Targeting leukemia cells gene addiction presents new strategy for treatment
8. Novel Parkinson's Treatment Strategy Involves Cell Transplantation
9. A new strategy normalizes blood sugars in diabetes
10. Promising strategy for treatment of lung cancer
11. ActiveStrategy iRound™ is Launched to Enable Seamless Capture of Field-Level Performance Management Data
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Strategy discovered to activate genes that suppress tumors and inhibit cancer
(Date:7/12/2014)... Warminster, PA (PRWEB) July 12, 2014 ... Paddock covering a variety of men’s health questions. ... issues specific to men, why women live longer than ... article, Men's Health Made Simple featured on ... can get a hernia at any age. If you ...
(Date:7/12/2014)... A recent article released by Seattle's well known plastic ... those seeking cosmetic surgical procedures in summer months . ... heat begins to enliven the rainy Pacific Northwest, many people ... they didn’t work out as much during the winter as ... surge of people eager to look their best for their ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 ... score of 4.1 out of 5. This above-average ... have been underpinning buyer negotiation power over the ... analyst Anna Son, “during the period, surging demand ... costs associated with new product development, have placed ...
(Date:7/11/2014)... 12, 2014 Recently, MagicQuinceaneraDresses.com, the popular ... new collection of 2014 Quinceanera dresses . The ... want to look fashionable without paying a large amount ... up to 57% off. , The company’s online shop ... get amazing special occasion outfits. In addition to exquisite ...
(Date:7/11/2014)... Ticket Down reports that tickets to the ... World Cup Match between Brazil and Netherlands are ... on Saturday, July 12th at Estadio Nacional de Brasilia Mane ... place on Sunday, July 13th at Estadio Jornalista Mario Filho ... the 2014 World Cup are guaranteed to be authentic and ...
Breaking Medicine News(10 mins):Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 4Health News:Cheap Quinceanera Dresses Now Available At MagicQuinceaneraDresses.com 2Health News:Argentina vs. Germany World Cup Finals Tickets & Brazil vs. Netherlands 3rd Place World Cup Tickets Are in Huge Demand 2
... The Campaign for Cancer Prevention (CCP) began in,2007 ... globe who care about preventing cancer. It has now,grown ... a leading initiative on the social media,platform, Causes.com. Nearly ... Brigham and Women,s,Hospital (BWH), a Harvard Medical School flagship ...
... male breast cancer is low and most men do not even ... new research from the University of Leeds. Breast cancer ... diagnoses in women in the UK each year. However around 340 ... cancer each year and around 70 men will die. Funded ...
... technology tweaking that would rival MacGyver, a team of ... everyday iPhones into medical-quality imaging and chemical detection devices. ... typical app, the decked-out smartphones are able to use ... The team will present their findings at the ...
... by psychologists at the University of Bristol, has found that ... it to be more filling. This finding, published (online ahead ... , is important because it reveals one way in which ... overweight. Children are at risk of obesity due to ...
... HealthDay Reporter , FRIDAY, Sept. 30 (HealthDay News) -- ... as psychiatric drugs in reducing the agitation that often ... In a three-month period, nursing home residents who ... music, mime and humorous props showed a significant reduction ...
... in The Endocrine Society,s Journal of Clinical Endocrinology ... a young age is associated with elevated long-term ... shown that long-term elevated cortisol levels lead to ... Shift work, defined as work performed primarily ...
Cached Medicine News:Health News:Campaign for Cancer Prevention connects 6 million+ members on Facebook Causes to research at BWH 2Health News:Campaign for Cancer Prevention connects 6 million+ members on Facebook Causes to research at BWH 3Health News:Researchers call for more awareness of male breast cancer as cases rise 2Health News:Researchers call for more awareness of male breast cancer as cases rise 3Health News:Researchers transform iPhone into high-quality medical imaging device 2Health News:Researchers transform iPhone into high-quality medical imaging device 3Health News:Researchers transform iPhone into high-quality medical imaging device 4Health News:New study finds familiarity increases the fullness that children expect from snack foods 2Health News:Laughter Might Be Good Medicine for Alzheimer's Patients 2Health News:Laughter Might Be Good Medicine for Alzheimer's Patients 3
(Date:7/11/2014)... 11, 2014 Research and Markets  has ... Market 2014-2018" report to their offering. ... needle is a hollow needle commonly used with a ... to extract fluids from it. A hypodermic needle is ... substances that cannot be ingested. Hypodermic needles are broadly ...
(Date:7/11/2014)... , July 11, 2014 Research and ... of the "Immunoprotein Diagnostic Testing Market - ... highest CAGR of 6% and is expected to ... to their offering. ... diagnostic testing has been segmented according to immunoprotein ...
(Date:7/10/2014)... NEWPORT NEWS, Virginia , 11. ... führender Hersteller von Kameras für die ... Brust (MBI/BSGI), hat heute die CE-Zulassung ... Mit dem CE-Zeichen kann Dilon das ... seinen Vertriebsbereich auf den Großteil der ...
Breaking Medicine Technology:Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2Dilon erhält CE-Zulassung für sein Navigator-Gamma-Sondensystem 2
... , St. Andrews Country Club Hosts the 3rd ... Jan. 8 St. Andrews Country Club of Boca Raton ... raise $405,000 through the 3rd annual ,Morgan & Friends Fight Cancer, Tournament ... third year of hosting the event, the membership has raised $1.15 million, ...
... , TROY, Mich., Jan. 8 Somanetics Corporation (Nasdaq: ... quarter and fiscal year ended November 30, 2009 before the opening ... with releasing its financial results, the Company will host a conference ... same day. , On the conference call, Bruce ...
Cached Medicine Technology:St. Andrews Country Club of Boca Raton Members Team Up With Morgan Pressel to Raise $405,000 to Fight Breast Cancer 2St. Andrews Country Club of Boca Raton Members Team Up With Morgan Pressel to Raise $405,000 to Fight Breast Cancer 3St. Andrews Country Club of Boca Raton Members Team Up With Morgan Pressel to Raise $405,000 to Fight Breast Cancer 4Somanetics Corporation to Release Fourth Quarter and Fiscal 2009 Financial Results and Host Conference Call January 21, 2010 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: