Navigation Links
Strategy discovered to activate genes that suppress tumors and inhibit cancer
Date:5/21/2012

A team of scientists has developed a promising new strategy for "reactivating" genes that cause cancer tumors to shrink and die. The researchers hope that their discovery will aid in the development of an innovative anti-cancer drug that effectively targets unhealthy, cancerous tissue without damaging healthy, non-cancerous tissue and vital organs. The research will be published in the Journal of Biological Chemistry.

The team, led by Yanming Wang, a Penn State University associate professor of biochemistry and molecular biology, and Gong Chen, a Penn State assistant professor of chemistry, developed the new strategy after years of earlier research on a gene called PAD4 (peptidylarginine deiminase 4), which produces the PAD4 enzyme. Previous research by Wang and other scientists revealed that the PAD4 enzyme plays an important role in protecting the body from infection. The scientists compared normal mice with a functioning PAD4 gene to other mice that had a defective a PAD4 gene. When infected with bacteria, cells from the normal mice attacked and killed about 30 percent of the harmful bacteria, while cells from the defective mice battled a mere 10 percent. The researchers discovered that cells with a functioning PAD4 enzyme are able to build around themselves a protective, bacteria-killing web that Wang and his colleagues dubbed a NET (neutrophil extracellular trap). This NET is especially effective at fighting off flesh-eating bacteria.

Now, in their new study, Wang and his collaborators have focused on the less-desirable effects of the same PAD4 gene. While PAD4 is clearly a critical part of the body's defense strategy, the gene's over-expression may be linked to autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. One situation in which the PAD4 enzyme is markedly increased is in patients with certain cancers, such as breast, lung, and bone cancers. "We know that the PAD4 gene acts to silence tumor-suppres
'/>"/>

Contact: Barbara Kennedy
science@psu.edu
814-863-4682
Penn State
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Governor Rendell Proposes Budget With No Tax Increase, More Money for Public Schools, Strategy for Jobs, Plan to Address Future Deficits
2. SOKO Fitness & Spa Group Broadens Geographic Expansion Strategy
3. Keenan Chief Strategy Officer Selected to Join Editorial Board of Payers & Providers
4. Data Strategy Announces SurePath Services Offering for EMC Avamar
5. New strategy produces promising advance in cancer vaccines
6. New Cancer-Fighting Strategy Focuses On Signaling Molecules
7. Targeting leukemia cells gene addiction presents new strategy for treatment
8. Novel Parkinson's Treatment Strategy Involves Cell Transplantation
9. A new strategy normalizes blood sugars in diabetes
10. Promising strategy for treatment of lung cancer
11. ActiveStrategy iRound™ is Launched to Enable Seamless Capture of Field-Level Performance Management Data
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Strategy discovered to activate genes that suppress tumors and inhibit cancer
(Date:9/16/2014)... Terminsurancevirginia.com has released a new blog post ... insurance for obese clients. , Obese clients can ... It is unlikely for applicants to be denied coverage ... insurance costs. , Having life insurance is important ... insurance is available as temporary or permanent coverage and ...
(Date:9/16/2014)... Insuranceservicecompany.com has released a new blog ... investment tool. , Whole life insurance can provide financial ... used as an investment tool. Clients can save money for ... , A whole life insurance plan features a savings ... order for this policy to be profitable, clients should purchase ...
(Date:9/16/2014)... adage that warns against passing judgment based on ... species, apparently don,t share such human wisdom when ... University Polytechnic School of Engineering found that female ... fin color: yellow. The preference for yellow was ... , The reason may lie in the engineering-based, ...
(Date:9/16/2014)... According to a report by iData Research ( ... market research, the market for enteral feeding devices is ... U.S . and Europe combined. The market ... tubes, DPEJ tubes, PEG/J tubes. The enteral feeding replacement ... non-balloon tubes, nasogastric and nasojejunal tubes, enteral feeding pumps ...
(Date:9/16/2014)... 2014 Care Logistics® announced the ... of the Hospital Operating System™ that allows hospitals ... with staff capacity. For the first time, bed ... nursing and other staff capacity. , “The Demand ... anticipated admissions, discharges and transfers, real staff capacity ...
Breaking Medicine News(10 mins):Health News:Obese Clients Can Find Affordable No Exam Term Life Insurance at Terminsurancevirginia.com! 2Health News:Whole Life Insurance Can Be A Good Investment Tool for Retirement! 2Health News:Judging a fish by its color: for female bluefin killifish, love is a yellow mate 2Health News:Judging a fish by its color: for female bluefin killifish, love is a yellow mate 3Health News:Over 17 Million Enteral Feeding Device Placement Procedures is Expected to be Performed in the U.S. and Europe in 2020: Market Led by Covidien, Kimberly-Clark and Abbott 2Health News:Over 17 Million Enteral Feeding Device Placement Procedures is Expected to be Performed in the U.S. and Europe in 2020: Market Led by Covidien, Kimberly-Clark and Abbott 3Health News:Care Logistics Launches Demand Logistics as Part of the Hospital Operating System 2
... ) launches the GlaceComplete product suite which seamlessly integrates EMR ... billing process. The product has been designed to reduce the ... for the average office based medical practice. , ... ...
... piezoelectric transducers in industrial applications, and to facilitate transducer evaluation in ... ... 26, 2009 -- Piezoelectric elements have a myriad of uses. They ... in a structure. They can be used to acoustically cancel noise, ...
... that is responsible for maintaining the health of the light-sensing ... retina for the first time. , The ability to see ... of many diseases of the eye long before a patient ... Investigative Ophthalmology and Visual Science ., "Our goal is to ...
... Feb. 25 PharmaNet Development Group, Inc. (the "Company") ... clinical development services, today reported preliminary net income for ... million, or $0.08 per diluted share, compared to net ... per diluted share, in the fourth quarter 2007. All ...
... for February 26, 2009 at 10:00 a.m. EST , EAST ... SVNT ) today reported financial results for the three months and ... 2008, the Company had a net loss of $24.2 million, or ... the year ended December 31, 2008, the Company had a net ...
... with record bookings and continued positive cash flow ... AMCS ), a leader in radiology ... reported unaudited financial results for the fourth quarter ... http://www.newscom.com/cgi-bin/prnh/20060202/AMICASLOGO ) Q4 Financial Highlights Revenue ...
Cached Medicine News:Health News:Glenwood Systems, LLC Improves Medical Billing Process with GlaceComplete 2Health News:Glenwood Systems, LLC Improves Medical Billing Process with GlaceComplete 3Health News:Amped Up Piezos Are On The Move - Driving Piezos with an Affordable High Voltage Piezo Amplifier QPA200 2Health News:Amped Up Piezos Are On The Move - Driving Piezos with an Affordable High Voltage Piezo Amplifier QPA200 3Health News:'Dark cells' of living retina imaged for the first time 2Health News:'Dark cells' of living retina imaged for the first time 3Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 2Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 3Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 4Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 5Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 6Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 7Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 8Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 9Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 10Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 11Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 12Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 13Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 14Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 15Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 16Health News:PharmaNet Development Group Reports Fourth Quarter and Full Year 2008 Preliminary Financial Results 17Health News:Savient Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results 2Health News:Savient Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results 3Health News:Savient Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results 4Health News:Savient Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results 5Health News:Savient Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results 6Health News:Savient Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results 7Health News:Savient Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results 8Health News:Savient Pharmaceuticals Reports Fourth Quarter and Year-End 2008 Financial Results 9Health News:AMICAS Reports Financial Results for the Fourth Fiscal Quarter and Year Ended December 31, 2008 2Health News:AMICAS Reports Financial Results for the Fourth Fiscal Quarter and Year Ended December 31, 2008 3Health News:AMICAS Reports Financial Results for the Fourth Fiscal Quarter and Year Ended December 31, 2008 4Health News:AMICAS Reports Financial Results for the Fourth Fiscal Quarter and Year Ended December 31, 2008 5Health News:AMICAS Reports Financial Results for the Fourth Fiscal Quarter and Year Ended December 31, 2008 6
(Date:9/16/2014)... 16, 2014   Evana Automation Specialists , a ... and test systems, recently received a contract to provide ... manufacturer. The Evana solution will help error-proof the process ... well as reduce labor. A catheter ... robotic assembly cell. The robot will pick the adapter, ...
(Date:9/16/2014)... Conn. , Sept. 16, 2014   ... owned subsidiary of TriStar Wellness Solutions(R), Inc. ... marketer of advanced medical products, announced today that ... has grown by 39 percent, and microdispersed oxidized ... though August 2014.  Overall, TWSI expects third quarter ...
(Date:9/16/2014)... On September 25 to 26, 2014, China,s ... manufacturing - MEDTEC China  - will mark its 10th ... Center, bringing together close to 300 leading global suppliers ... medical-grade raw materials, parts and processing technologies. ... visitor pre-registration to be completed. To date, more than ...
Breaking Medicine Technology:Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 2Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 3HemCon Medical Technologies, Inc. Projects Strong Third Quarter Revenues 2HemCon Medical Technologies, Inc. Projects Strong Third Quarter Revenues 3HemCon Medical Technologies, Inc. Projects Strong Third Quarter Revenues 4MEDTEC China 2014: Seven Highlights Not to Miss! 2MEDTEC China 2014: Seven Highlights Not to Miss! 3MEDTEC China 2014: Seven Highlights Not to Miss! 4
...  Bionovo, Inc. (Nasdaq: BNVI, BNVID) announced today that it ... effective with the opening of trading on August 31, 2010. ... this time is to better enable the company to maintain ... Market. The company,s common stock will continue trading on The ...
... Laerdal Medical has been at the cutting ... launched its famous Resusci Anne in 1960. Fifty ... as it launches its latest SimMan patient simulator, ... ) (Photo: http://www.newscom.com/cgi-bin/prnh/20100830/NY56743 ) ...
Cached Medicine Technology:Bionovo Announces Reverse Stock Split 2Bionovo Announces Reverse Stock Split 3Laerdal Introduces SimMan Essential 2Laerdal Introduces SimMan Essential 3
Ruschelit® PVC. Siliconized. Stainless steel spiral reinforced. High volume/low pressure cuff. Permanent connector. X-ray opaque. Single use. Sterile...
Tube for Right Bronchus - Ruschelit™ PVC. Color coded for easy identification of ports, balloons and 15mm connectors. High volume/low pressure cuffs. With Carina hook. X-ray opaque line. Gradua...
... For Laryngotracheal Instillation of Topical Anesthetic, ... populations, this cuffed tube incorporates an ... spray application of topical anesthetic above ... offers three endotracheal tubes designs which ...
SPIRAL-FLEX® Reinforced Oral/Nasal Uncuffed Endotracheal Tubes...
Medicine Products: