Navigation Links
Strategy developed to improve delivery of medicines to the brain
Date:9/7/2012

New research offers a possible strategy for treating central nervous system diseases, such as brain and spinal cord injury, brain cancer, epilepsy, and neurological complications of HIV. The experimental treatment method allows small therapeutic agents to safely cross the blood-brain barrier in laboratory rats by turning off P-glycoprotein, one of the main gatekeepers preventing medicinal drugs from reaching their intended targets in the brain.

The findings appeared online Sept. 4 in the Proceedings of the National Academy of Sciences, and is the result of a study from scientists at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health.

"Many promising drugs fail because they cannot cross the blood-brain barrier sufficiently to provide a therapeutic dose to the brain," said David Miller, Ph.D., head of the Laboratory of Toxicology and Pharmacology at NIEHS, and leader of the team that performed the study. "We hope our new strategy will have a positive impact on people with brain disorders in the future."

In a two-pronged approach, the research team first determined that treating rat brain capillaries with the multiple sclerosis drug marketed as Gilenya (fingolimod) stimulated a specific biochemical signaling pathway in the blood-brain barrier that rapidly and reversibly turned off P-glycoprotein. Team members then pretreated rats with fingolimod, and administered three other drugs that P-glycoprotein usually transports away from the brain. They observed a dramatic decline in P-glycoprotein transport activity, which led to a threefold to fivefold increase in brain uptake for each of the three drugs.

Ronald Cannon, Ph.D., is a staff scientist in the Miller lab and first author on the paper. He said one of the burning questions the team wants to tackle next is to understand how the signaling system turns off P-glycoprotein. He equates the mechanism to what happens when a person flips a light switch.

"If you physically turn off a light using the button on the wall, the light will go out because the electrical current to the light bulb has been interrupted," Cannon explained. "But what happens when the signaling pathway shuts down P-glycoprotein? Does it bring in another protein to bind to the pump, take away its energy source, modify the structure of the pump, or something else?"

Cannon said the paper's findings open a new way of thinking regarding targets for drug design, a thought that is emotionally gratifying for him and many other researchers whose scientific discoveries generally don't directly translate into helping people with illnesses.

"Although much more research needs to be done, delivering therapeutics to the central nervous system is one of the final frontiers of pharmacotherapy, Cannon added."


'/>"/>

Contact: Robin Arnette
arnetter@niehs.nih.gov
919-541-5143
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Related medicine news :

1. Scientists devise new strategy to destroy multiple myeloma
2. Strategy May Help ER Docs Spot Heart Attacks Within an Hour
3. Scientists develop new strategy to overcome drug-resistant childhood cancer
4. Cell differentiation as a novel strategy for the treatment of an aggressive type of skin cancer
5. New gene transfer strategy shows promise for limb girdle and other muscular dystrophies
6. UT Southwestern study shows treating diabetes early, intensively is best strategy
7. VisionWare and Serco Partner to Enable ‘Digital by Default’ Strategy
8. New drug strategy attacks resistant leukemia and lymphoma
9. Strategy discovered to activate genes that suppress tumors and inhibit cancer
10. Discovery suggests new combination therapy strategy for basal-like breast cancers
11. White House Drug Policy Shifts Strategy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 19, 2017 , ... ... Thailand presided over the Amazing Thailand Health and Wellness Tourism Showcase 2017 yesterday, ... Noppadon Pakprot, Deputy Governor for Tourism Products and Business at TAT said, “Thailand ...
(Date:8/18/2017)... NY (PRWEB) , ... August 18, 2017 , ... ... of this summer’s edition of “Vision & Hearing,” advocating for active, healthy lifestyles ... focuses on resources available for individuals with hearing impairments and shares the latest ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... asset protection assistance to communities in North-Central West Virginia, is embarking on a ... at-risk boys in the area. , The Chestnut Mountain Ranch (CMR) is a ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... The Golseth ... in the Dallas/Fort Worth area, is spearheading a regional charity campaign organized to provide ... , In early June of this year, Christina and her children returned from out ...
(Date:8/18/2017)... , ... August 18, 2017 , ... Inc. magazine has ... the most prestigious ranking of the nation's fastest-growing private companies. This marks the eighth ... Inc. 5000 ranking . This year’s ranking reflects ASH’s 76 percent overall revenue ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... , Aug. 3, 2017  Opioid addiction and other ... up healthcare costs and threatening outcomes, were problems taken ... and IVD industry that support them, met this week. ... researcher said that drugs of abuse, procalcitonin and acute ... at the organization,s 69th meeting in San ...
(Date:8/2/2017)... , Aug. 2, 2017  Life Flight Network and ... The agreement improves patient care and operational efficiency for patients ... Springfield , Cottage Grove , and ... medical transportation. PeaceHealth and Life Flight Network work collaboratively to ... during transport, or when a time sensitive emergency exists. ...
(Date:7/31/2017)... Mich. , July 31, 2017  Diplomat Pharmacy, Inc. ... in southeast Michigan by Crain,s ... ranks private and public companies by three-year revenue growth. This ... To view the complete list, visit ... Fast 50 is an incredible triumph," said Phil Hagerman ...
Breaking Medicine Technology: