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Neurogenesis is the process by which neurons are created. This process is most active during pre-natal development when neurogenesis is responsible for populating the growing brain. Neural stem cells (NSCs) are the self-renewing, multipotent cells that differentiate into the main phenotypes of the nervous system. These cell types include neurons, astrocytes, and oligodendrocytes. Neural progenitor cells (NPCs) are the progeny of stem cell division that normally undergo a limited number of replication cycles in vivo.
The terms neuronal and neural also need to be defined. Technically speaking, “neuronal” means “pertaining to neurons,” and “neural” means “pertaining to nerves, which the cordlike bundles of fibers are made up of neurons.” Since both terms ultimately are descriptive of neurons, the scientific community uses the terms “neuronal” and “neural” interchangeably. The complexity of this issue is explored from a strategic perspective within this report.
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In particular, when naming products, companies are advised to use the term “neural” rather than “neuronal,” both in reference to stem cells and progenitor cells, in order to best position products within the marketplace. Also of interest is that when “stem cell” versus “progenitor cell” publications are compared, neural/neuronal “stem cell” publication rates continue to outpace neural/neuronal “progenitor cell” publications by over 200% over a trailing two-year period.
In summary, an understanding of neural stem cell language and terminology can substantially improve product naming, strategic positioning, and the effectiveness of marketing communications. These subtleties as explored in detail within the context of this industry report.
In addition, the report focuses on: recent advances in neural stem cell research applications; research priorities by market segment; opportunities for profitable product and technology development; the competitive environment for NSC products; detailed market size analysis; market trends and metrics; five-year projections; and the needs and decision-making of NSC scientists.
To facilitate research resulting from these advances, a large and diverse market has emerged for neural stem cell products, platforms, and technologies. In total, the neural stem cell product marketplace is comprised of the global sales of these items. One thriving component of this marketplace is the segment of companies that sell NSC research products to scientists.
Termed “research supply companies” or “research product vendors,” large companies selling neural stem cell research products include EMD Millipore, Life Technologies, Thermo Fisher Scientific, and STEMCELL Technologies, as well as more than 40 other suppliers that range in size from multinational corporations to small specialty companies. Together, these research supply companies represent a substantial annual percentage of NSC product sales. Each of these industry participants are identified within the context of this report. As of 2013, EMD Millipore, known as Merck Millipore outside of the United States and Canada, is the leader in neural stem cell product development for the scientific community. A Canadian company, STEMCELL Technologies, is a close second in the area of NSC product development for scientists.
Within this report, profitable opportunities for NSC research product development are revealed. Specifically, competitors looking to enter the NSC research products marketplace would do well to focus their energy on the areas considered highest priority by the scientific community, specifically cell-based therapies and standardized neurotoxicity assays. Due to recent legislative initiatives, interest in the latter is expected to increase significantly in the next several years.
Furthermore, companies looking to enter the NSC product market could also focus their efforts on areas in which available products are not yet optimized for use with rat or mouse neural stem cells. Or, research supply companies could choose to focus product development on areas where human neural stem cell products are not yet available, although there would be some necessary work-around due to patent restrictions. Companies could also develop products for which there is little market competition, such as hESC-derived neural progenitors, kits for analysis of NSC differentiated progeny, NSC blotting and nucleofaction kits, and PCR arrays. Finally, companies could choose to explore varied sources from which to potentially derive neural stem cell products, such as human umbilical cord blood and derivatives of neural rosette cell lines.
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