Story ideas from molecular & cellular ...(ify proteins that have undergone various...),Health

Date:9/12/2007

ify proteins that have undergone various changes in their structure. The researchers used this technique to detect a protein on the membrane of cells called platelet-derived growth factor receptor beta, which undergoes changes that will promote cell proliferation and movement. The technique is more sensitive and selective than other currently-used techniques, that is, it does not miss as many proteins as the other techniques do and the rate of mix-ups among the detected proteins is lower.

Article: In Situ Detection of Phosphorylated Platelet-derived Growth Factor Receptor Beta Using a Generalized Proximity Ligation Method, by Malin Jarvius, Janna Paulsson, Irene Weibrecht, Karl-Johan Leuchowius, Ann-Catrin Andersson, Carolina Wahlby, Mats Gullberg, Johan Botling, Tobias Sjoblom, Boyka Markova, Arne Ostman, Ulf Landegren, and Ola Soderberg

MEDIA CONTACT: Ola Soderberg, Uppsala University, Uppsala, Sweden; tel: 46-18-4714868; e-mail: ola.soderberg@genpat.uu.se

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Contact: Pat Pages ppages@asbmb.org 301-634-7366 American Society for Biochemistry and Molecular Biology Source:Eurekalert

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