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Story ideas from molecular & cellular proteomics
Date:9/12/2007

d at will. The chemicals released by the eggs also attract molecules from the immune system but this time the chemicals fool the immune system into helping them escape from the body through feces and spread in the environment. These results provide new clues as to how the worms infect the human body and may help design drugs that target some of these chemicals in the future.

Article: Glycomics Analysis of Schistosoma mansoni Egg and Cercarial Secretions, by Jihye Jang-Lee, Rachel S. Curwen, Peter D. Ashton, Berangere Tissot, William Mathieson, Maria Panico, Anne Dell, R. Alan Wilson, and Stuart M. Haslam

MEDIA CONTACT: Stuart M. Haslam, Imperial College London, United Kingdom; tel: 44-207-594-5222; e-mail: s.haslam@imperial.ac.uk

New insight into lethal shrimp viral disease

Researchers report the most complete list so far of proteins present in a virus that causes severe shrimp mortality and significant economic losses to shrimp cultivation worldwide. This discovery could help understand how the virus is assembled and how it infects shrimps.

White spot syndrome is a viral infection of shrimps that is highly lethal and contagious, killing shrimps within 7 to 10 days. In 1993, this disease resulted in a virtual collapse of the Chinese shrimp farming industry and, by 1996, it had severely affected East and South Asia. The disease was reported in the United States in late 1995. Although no treatment for the disease is available yet, scientists have been studying the proteins that make up the virus to understand how it infects shrimps and avoids their immune system.

Choy-Leong Hew and colleagues showed that the virus is assembled by at least 58 proteins, including 13 proteins which are reported for the first time. The scientists also localized 33 of the proteins on the envelope, which is
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Contact: Pat Pages
ppages@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

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