Navigation Links
Stored Ovarian Tissue Needs Testing Before Re-Implantation
Date:4/24/2008

Inadequate safeguards could mean a return of cancer, study warns

THURSDAY, April 24 (HealthDay News) -- Cancer can return in patients who have been successfully treated if ovarian or testicular tissue they had stored in hope of regaining fertility is transplanted back into their bodies without it being adequately checked for cancer cells, according to a new report.

Researchers at two university hospitals in Israel, writing in the April 22 issue of Human Reproduction, then warned that most fertility centers lack the skills and technology to ensure the tissue is free of residual cancer cells.

Hundreds of cancer patients worldwide have ovarian tissue and testicular tissue frozen in the hope of being able to have children once their treatment has finished. However, it is possible for the original cancer to re-infect the body when the tissue is re-implanted.

"We think it's vitally important to raise awareness amongst cancer patients, fertility specialists, oncologists and hematologists. There are few fertility centers in the world with the expertise and the technology to run the types of tests on tissue that are needed to detect residual cancer," first author Dror Meirow, who leads the fertility preservation program at Chaim Sheba Medical Center, said in a prepared statement.

Over 10 years, Meirow and his team collected and froze several strips of tissue from 56 women about to receive chemotherapy for hematological cancers such as Hodgkin lymphoma, non-Hodgkin lymphoma and leukemia. Over the years, the strips were thawed and checked for cancer cells using the most modern methods available at the time. The results were compared with the same tests carried out on the patients' diseased tissue at the time of harvest to ensure the tests were capable of detecting cancer when it was known to be present.

Only one test ever detected minimal residual disease in ovarian tissue: modern, highly sensitive, real-time polymerase chain reaction (PCR), a test that amplifies sections of DNA to detect molecular markers that would indicate the presence of cancer cells. The authors suggested that, as methods for detecting cancer cells are improving all the time, and ovarian tissue can be stored for more than 10 years, tests to detect residual disease should be carried out just before transplantation rather than at the time of collection. To do this, it is necessary to freeze smaller pieces of ovarian tissue separately for minimal residual disease investigation.

"The next step is to inform patients about the increasing success of ovarian tissue transplantation, to continue to improve the success of ovarian tissue transplantation, but also to call on fertility centers that store ovarian tissue to look for minimal residual disease and to start freezing tissue now for future investigation," Meirow said. "All of this holds true for testicular tissue, too, although we are not so advanced in successfully removing, storing and transplanting testicular tissue as we are with ovarian tissue."

More information

The American Cancer Society has more about ovarian cancer treatment.



-- Kevin McKeever



SOURCE: European Society for Human Reproduction and Embryology, news release, April 21, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Cancer could return unless stored ovarian tissue undergoes adequate testing before re-implantation
2. Former Actor has Mobility Restored With Power Wheelchair Gift From The Scooter Store
3. Lymphatic vessel and lymph node function are restored with growth factor treatment
4. 600 Smiles Restored Thanks to the AACDCFs Give Back A Smile Program - October Marks National Domestic Violence Awareness Month
5. Scientists Develop Natural Protection for Stored Foods
6. Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
7. FASgen Diagnostic Tests Identify Ovarian Cancer Progression and Apoptosis
8. Specialized Care for Ovarian Cancer Improves Outcomes
9. Recurrent low-grade carcinoma of the ovary less responsive to chemo than more common ovarian cancers
10. Advanced-stage ovarian cancer patients with BRCA live longer, may respond better to treatment
11. Gleevec May Disrupt Ovarian Function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... ... 2016 , ... A man who has struggled to quit smoking, a man who has struggled ... to find solutions to his problems – and he did. Now Nabat, a serial entrepreneur ... introduce his breakthrough inventions to the world and better people's lives. His own experience with ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Bell Agency, a ... latest beneficiary of their ongoing community enrichment program. The current campaign fundraises for ... Donations are now being accepted at: http://www.angelsanddoves.com/donate.html . , Angels & Doves ...
(Date:2/8/2016)... ... February 08, 2016 , ... Eating disorders ... significant number of women and men with eating disorders report a history of ... predicts the development of an eating disorder. , At the 2016 iaedp ...
(Date:2/8/2016)... ... 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to a product ... from a cluster of melanin when exposed to sunlight. Although most moles are benign ... of embarrassment. Historically, mole removal has involved a painful, often expensive visit ...
(Date:2/7/2016)... ... February 07, 2016 , ... Women’s Excellence ... and the most minimally invasive approaches. , Women who have had multiple vaginal ... risk factors include surgery to the pelvic floor, connective tissue disorders, and obesity. ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 2016 In a historic vote among its members this weekend, ... medical cannabis cultivation facility and dispensary on tribal land near ... as a provider for patients in the state,s Medical Cannabis Program. ... a provider for patients in the state,s Medical Cannabis Program. ... the project and pursue designation from the State of New ...
(Date:2/8/2016)... 2016 http://www.researchandmarkets.com/research/x6mkjm/knee ) has ... Devices Market by Product Type (Primary (Cemented & ... Canada, Eu-5, Japan, Bric, Turkey, Indonesia - Global ... their offering. --> http://www.researchandmarkets.com/research/x6mkjm/knee ) ... Reconstruction Devices Market by Product Type (Primary (Cemented ...
(Date:2/8/2016)... ARBOR, Mich. , Feb. 8, 2016  The ... Arbor announced today that, as part of ... become one of the first hospitals in the U.S. ... Karin Muraszko , M.D., U-M,s chair of neurosurgery. ... chair of neurosurgery. --> The BrightMatter ...
Breaking Medicine Technology: