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Stopping schizophrenia before it starts?
Date:1/28/2010

The onset of schizophrenia is not easy to predict. Although it is associated with as many as 14 genes in the human genome, the prior presence of schizophrenia in the family is not enough to determine whether one will succumb to the mind-altering condition. The disease also has a significant environmental link.

According to Prof. Ina Weiner of Tel Aviv University's Department of Psychology, the developmental disorder, which usually manifests in early adulthood, can be triggered in the womb by an infection. But unlike developmental disorders such as autism, it takes many years for the symptoms of schizophrenia to develop.

"Pharmacological treatments for schizophrenia remain unsatisfactory, so clinicians and researchers like myself have started to dig in another direction," says Prof. Weiner. "The big question asked in recent years is if schizophrenia can be prevented."

Revolutionizing the treatment

In their study, recently reported in Biological Psychiatry, Prof. Weiner and her colleagues Dr. Yael Piontkewiz and Dr. Yaniv Assaf sought to discover biological cues that would help trace the progression of the disease before symptoms manifested. "If progressive brain changes occur as schizophrenia is emerging, it is possible that these changes could be prevented by early intervention," she says. "That would revolutionize the treatment of the disorder.

"We wondered if we could use neuro-imaging to track any early-onset changes in the brains of laboratory animals," Prof. Weiner says. "If so, could these changes and their accompanying schizophrenia-like symptoms be prevented if caught early enough?"

Beyond a doubt

Prof. Weiner and her team gave pregnant rats a viral mimic known to induce a schizophrenia-like behavioral disorder in the offspring. This method simulates maternal infection in pregnancy, a well known risk factor for schizophrenia. Prof. Weiner demonstrated that the rat offspring w
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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

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