Navigation Links
Stopping harmful oral bacteria in its path is goal for Case Western Reserve researcher
Date:7/14/2009

CLEVELANDThe best way to keep bacteria from doing any damage is to stop them in their tracks before they can start down their pathological road to destruction.

Yiping Han, associate professor at the Case Western Reserve University School of Dental Medicine, aims to understand how to build roadblocks for a common bacterium that's harmless in a mother's mouth but can turn deadly when it reaches an unborn child. She has received a five-year, $1.85 million grant from the National Institute of Dental and Craniofacial Research (NIDCR) at the National Institutes of Health to fund the effort.

This is Han's second NIDCR RO1 award. She's published more than 10 papers from previous research related to the bacterium, Fusobacterium nucleatum, that creates havoc once it leaves the mouth and enters the blood stream.

She has discovered an adhesin protein molecule, called FadA, in the genes of F. nucleatum. This adhesin, or binding agent, on the bacteria allows them to connect with receptors on epithelial cells in the mouth and later the endothelial cells of the placenta.

In tests, bacteria without FadA had less binding capability compared to those with the adhesin, Han and a team of researchers report on this finding in the July issue of the journal Infection and Immunity.

"With this new grant, we will be able to continue a functional analysis of FadA," said Han. Her research group will look not only at the binding agent but the receptors on the host epithelial and endothelial cells that promote the binding of the oral bacteria.

"In some way, the receptors on the host cell activate a signal that puts into action a cascade of processes that allow the bacteria to penetrate the epithelial and endothelial linings and then colonize," explains Han.

"We want to block the bacteria before it can do any damage," Han says. "It's an upstream approach to go back to where the whole process begins and sto
'/>"/>

Contact: Susan Griffith
susan.griffith@case.edu
216-368-1004
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stopping Statins After Stroke Doubles Death Risk
2. Stopping Tysabri May Worsen MS
3. On 30th Anniversary, Angioplasty Celebrated as Modern Medical Breakthrough in Stopping Heart Attack
4. Hands2GO(R) Hand Sanitizer Offers Alcohol-Free Alternative to Stopping the Spread of Flu at School and Work
5. Common drug for stopping preterm labor may be harmful for babies
6. New Sedona Stopping Diabetes Program
7. New Booklet Reveals 12 Proven Methods for Stopping MRSA from Infecting Your Feet and Your Familys Feet
8. First 90 Days After Stopping Plavix Most Dangerous
9. Physicians focus on stopping pain epidemic
10. Fugitive cancer cells can be blocked by stopping blood cells that aid them
11. Stopping a receptor called nogo boosts the synapses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... Ogawa’s new massage chairs tout innovative functionality that ... humanlike than ever before. With the goal of bringing wellness to the world, Ogawa ... SuperTrac. , As in its name, the Ogawa Refresh aims to ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... cards, launched its consumer-friendly, informational video this week to coincide with back-to-school and ... . , According to the CDC, elementary school children are sick an ...
(Date:9/1/2015)... ... 2015 , ... Éminence Organic Skin Care is adding a ... This revolutionary collection of natural peel solutions complements the existing routine for each ... with alpha hydroxy acids and natural active ingredients, these results-oriented peels deliver visible ...
(Date:9/1/2015)... ... September 01, 2015 , ... Dr. Trace Curry successfully placed ... Cincinnati. In the last month the FDA has approved two intra-gastric balloons, the ... These procedures represent the first incisionless, reversible, weight loss procedures available to Americans. ...
(Date:9/1/2015)... Canada (PRWEB) , ... September ... ... announce PRO Archiver for Alfresco, a next-generation customer communications archiving solution ... built with market-leading technology from Crawford and helps organizations save millions of ...
Breaking Medicine News(10 mins):Health News:Ogawa World USA Releases New Massage Chairs to the US 2Health News:Ogawa World USA Releases New Massage Chairs to the US 3Health News:USA Medical Card Launches New FAQ Video During Back-to-School 2Health News:Éminence Organic Skin Care Introduces Results-Oriented Exfoliating Peels for Every Skin Type 2Health News:Éminence Organic Skin Care Introduces Results-Oriented Exfoliating Peels for Every Skin Type 3Health News:Dr. Trace Curry Performs First ORBERA™ Intra-gastric Balloon in Ohio at JourneyLite, a New Incisionless Option For The Treatment of Obesity 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 2Health News:Introducing Next-Generation Archiving Solution PRO Archiver for Alfresco® 3
... safely undergo essential dental treatment and receive topical and ... a study published in the June issue of ... Although obstetricians generally consider dental care safe for pregnant ... address this issue, researchers compared safety outcomes from the ...
... government,authorities reel from a record breaking year of food ... brings to light the science --,and the politics -- ... food and nuclear industries., Written plainly and passionately, ... timely and fact-filled. The book details the rise,of irradiation ...
... BeaconEquity.com announces the,availability of TraderNotes on stocks that are ... the daily trading notes for free by visiting:, http://www.BeaconEquity.com/m ... Sheets: LLSR),Elbit Imaging Ltd. (Nasdaq: EMITF ), Biolase ... (OTC Bulletin Board: OISI), Alcon Inc.,(NYSE: ACL ), ...
... up for America,s small,businesses., WASHINGTON, June 10 ... Democratic National Committee:, (Logo: http://www.newscom.com/cgi-bin/prnh/20080519/DNCLOGO ... up for America,s small businesses and,that "[e]ntrepreneurs are ... But in reality as president Senator McCain,s health ...
... IL June 10, 2008 Various intervention strategies have ... a factor that might affect exposure to interventionsis gender. ... Social Psychology reviewed the behavior of participants exposed ... and women were likely to avoid gender-mismatched brochures. Women, ...
... (NYSE:,HRC) invites you to listen to a presentation by ... Hill-Rom. He will be speaking,at the Jefferies Healthcare Conference ... p.m. EDT., You are invited to listen to ... or access it directly at, http://www.wsw.com/webcast/jeff26/hb . ...
Cached Medicine News:Health News:Essential dental treatment safe for pregnant women, says ADA journal study 2Health News:New Book Reveals Decades-Long Food Safety PR Scam 2Health News:BeaconEquity.com Issues TraderNotes on Medical Instruments and Supplies Stocks: LLSR, EMITF, BLTI, OISI, ACL, LMNX, MELA, PMII 2Health News:BeaconEquity.com Issues TraderNotes on Medical Instruments and Supplies Stocks: LLSR, EMITF, BLTI, OISI, ACL, LMNX, MELA, PMII 3Health News:Democratic National Committee McCain Myth Buster: John McCain and America's Small Businesses 2Health News:Democratic National Committee McCain Myth Buster: John McCain and America's Small Businesses 3Health News:Gender affects reaction to HIV-prevention materials 2
(Date:8/31/2015)...  On August 5, 2015, the U.S. District Court ... denied motions to dismiss securities class action claims against ... of its directors. The class actions allege that the ... to artificially inflate Galena,s stock price, and during an ... inflated, sold massive amounts of their personally-held shares. ...
(Date:8/31/2015)... , Aug. 31, 2015 Regen BioPharma, ... development of a novel means of delivering its ... RGBP-248, to liver tumors utilizing a clinically approved ... overcomes previous hurdles with gene silencing therapeutics in ... delivered throughout the whole body.  By utilizing a ...
(Date:8/31/2015)... DIEGO , Aug. 31, 2015  Qualcomm ... its subsidiary, Qualcomm Life, Inc., is ... develop chronic care management solutions powered by Qualcomm ... Coordination Platform to enable continuous care, informed interventions ... were announced at Qualcomm Life,s annual Connect ...
Breaking Medicine Technology:Galena Biopharma, Inc. Stock Alert: Schubert Firm Investigates Potential Breaches of Fiduciary Duty 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 2Regen BioPharma, Inc. Develops BORIS Gene Silencing Based Treatment for Unresectable Liver Cancer 3Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 2Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 3Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 4Qualcomm Life Announces New Connected Health Collaborations at Connect 2015 5
... April 18, 2011 Altitude Organic Corporation (Pinksheets: ... announced today that it has launched its third-party ... headquarters.  Visit the DoctorMMJ.com website ( www.DoctorMMJ.com ) ... and entirely legal medical marijuana evaluation in Arizona. ...
... 2011 Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN ... Administration (FDA) has accepted for review the Company,s Biologics ... of the neovascular form of age-related macular degeneration (wet ... priority review of its BLA.  A Priority Review designation ...
Cached Medicine Technology:Altitude Organic Corporation Opens DoctorMMJ.com Physician Referral Service in Scottsdale, Arizona 2Altitude Organic Corporation Opens DoctorMMJ.com Physician Referral Service in Scottsdale, Arizona 3FDA Grants Priority Review for VEGF Trap-Eye for the Treatment of Wet Age-Related Macular Degeneration 2FDA Grants Priority Review for VEGF Trap-Eye for the Treatment of Wet Age-Related Macular Degeneration 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: