Navigation Links
Stopping dangerous cell regrowth reduces risk of further heart attacks
Date:12/6/2011

"After an arterial injury, the inner layer of cells in the artery begins to regrow. In the long term, this usually causes more harm than good", says Maria Gomez.

A common cause of arterial injuries is the clearing of blocked arteries often performed on patients who have had a heart attack.

"Initially the artery is opened up, but after a while new cell formation increases the risk of further heart attacks."

In animal experiments, the research groups have demonstrated the opposite effects of the two proteins. The carotid artery of rats was damaged with balloon dilation, simulating the procedure carried out on heart attack patients.

After two weeks, there was noticeably less new cell formation in the arteries that had more of the protein IRT-1. With AIF-1, the opposite effect was observed.

"The interesting thing is that both proteins are formed from the same gene and we have now found a mechanism to control the balance in the formation of the two. Using a new drug we can thus increase the amount of the 'good' protein, IRT-1. It is not an approved drug, but it has been tested on mice and appears to be tolerated well", says Maria Gomez.

The researchers have also analysed over 150 fatty deposits ('plaques') removed from the carotid arteries of patients.

"We saw that the dangerous plaques those that are unstable, easily rupture, are more inflamed and more often produce symptoms contain more AIF-1. Those with a higher proportion of the protein IRT-1 are less dangerous", observes Lisa Berglund, co-author of the published study.

Diabetes patients develop more plaques, and more often dangerous ones, than non-diabetics. Diabetics have a significantly higher risk of suffering a heart attack.

The regrowth of cells in the arteries also leads to negative changes in blood flow. It may even be the case that AIF-1 is involved in the actual formation of plaques in the arteries.

Heart attacks are the most common cause of death in Sweden and many patients have repeated attacks, which are treated by clearing constrictions in the arteries of the heart using various methods.

"If we could reduce the risk of repeat attacks, this would represent very significant progress", says Maria Gomez.


'/>"/>
Contact: Maria Gomez
Maria.Gomez@med.lu.se
46-702-226-216
Lund University
Source:Eurekalert

Related medicine news :

1. Stopping Daily Aspirin Boosts Heart Attack Risk: Study
2. ACP commends Congress for preserving patient access by stopping scheduled Medicare SGR cuts
3. Internists issue heartfelt plea for Congress to help patients by stopping Medicare SGR cuts
4. Researchers find new target for stopping tumors developing their own blood supply
5. Stopping smoking cessation treatments too soon may reduce odds of success for 45 percent of smokers
6. Non-IV-administered medication just as effective in stopping seizures
7. The Infrex Plus is Revolutionizing Pain Control by Stopping Pain & Eliminating Drugs for Chronic Pain Patients Who Suffered For Years
8. Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
9. Surgery May Boost Survival With Dangerous Heart Condition
10. Tests to catch the makers of dangerous legal high designer drugs
11. Herbal supplements may cause dangerous drug interactions in orthopaedic surgery patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... , ... Park Cities Pet Sitter has openings for both full-time and part-time ... 75209, 75219, 75220, 75225, 75229, 75230, 75231 and 75235 zip codes. These zip ... Hollow and Park Cities areas of the Metroplex. Candidates must love animals, have ...
(Date:5/3/2016)... Toronto, ON (PRWEB) , ... May 03, 2016 ... ... been recognized as one of Canada’s top Information and Communication Technology (ICT) companies ... top Canadian and Multinational ICT companies operating in Canada, as ranked by revenue. ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... ... general availability of the latest release of DocAve 6 Service Pack (SP) ... helps organizations migrate to SharePoint 2016 and take advantage of the platform’s latest ...
(Date:5/3/2016)... ... May 03, 2016 , ... Hydra Skin Sciences, a top-rated skincare company ... a revolutionary new anti-aging skin care product that integrates Snow Algae Powder ... sold over seventy-five thousand units worldwide within the first two months of release. , ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... the state-of-the-art Carnival Vista – the line’s largest cruise ship ever. To ... has created an infographic spotlighting the Carnival Vista ’s most exciting ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016 ... for Life Sciences, Product Development Capabilities in ... Science Customer Base . Indegene ... today announced the acquisition of Skura Corporation,s life ... leader in adaptive sales enablement technology for life ...
(Date:4/28/2016)... April 28, 2016   Click here for ... Inc. (NYSE: DPLO), the nation,s largest independent specialty ... definitive agreement to acquire Valley Campus Pharmacy, Inc., ... a leading specialty pharmacy that provides individualized patient ... . In 2015, TNH generated approximately $400 ...
(Date:4/28/2016)... April 28, 2016 ... George Phillips und Stephen Schmidt ... ArisGlobal®, ein führender Anbieter cloudbasierter ... heute bekannt, dass neue Führungskräfte zum Team ... sind, die vielfältige Erfahrungen mitbringen.  Dies wird ...
Breaking Medicine Technology: