Navigation Links
Stopping dangerous cell regrowth reduces risk of further heart attacks
Date:12/6/2011

"After an arterial injury, the inner layer of cells in the artery begins to regrow. In the long term, this usually causes more harm than good", says Maria Gomez.

A common cause of arterial injuries is the clearing of blocked arteries often performed on patients who have had a heart attack.

"Initially the artery is opened up, but after a while new cell formation increases the risk of further heart attacks."

In animal experiments, the research groups have demonstrated the opposite effects of the two proteins. The carotid artery of rats was damaged with balloon dilation, simulating the procedure carried out on heart attack patients.

After two weeks, there was noticeably less new cell formation in the arteries that had more of the protein IRT-1. With AIF-1, the opposite effect was observed.

"The interesting thing is that both proteins are formed from the same gene and we have now found a mechanism to control the balance in the formation of the two. Using a new drug we can thus increase the amount of the 'good' protein, IRT-1. It is not an approved drug, but it has been tested on mice and appears to be tolerated well", says Maria Gomez.

The researchers have also analysed over 150 fatty deposits ('plaques') removed from the carotid arteries of patients.

"We saw that the dangerous plaques those that are unstable, easily rupture, are more inflamed and more often produce symptoms contain more AIF-1. Those with a higher proportion of the protein IRT-1 are less dangerous", observes Lisa Berglund, co-author of the published study.

Diabetes patients develop more plaques, and more often dangerous ones, than non-diabetics. Diabetics have a significantly higher risk of suffering a heart attack.

The regrowth of cells in the arteries also leads to negative changes in blood flow. It may even be the case that AIF-1 is involved in the actual formation of plaques in the arteries.

Heart attacks are the most common cause of death in Sweden and many patients have repeated attacks, which are treated by clearing constrictions in the arteries of the heart using various methods.

"If we could reduce the risk of repeat attacks, this would represent very significant progress", says Maria Gomez.


'/>"/>
Contact: Maria Gomez
Maria.Gomez@med.lu.se
46-702-226-216
Lund University
Source:Eurekalert

Related medicine news :

1. Stopping Daily Aspirin Boosts Heart Attack Risk: Study
2. ACP commends Congress for preserving patient access by stopping scheduled Medicare SGR cuts
3. Internists issue heartfelt plea for Congress to help patients by stopping Medicare SGR cuts
4. Researchers find new target for stopping tumors developing their own blood supply
5. Stopping smoking cessation treatments too soon may reduce odds of success for 45 percent of smokers
6. Non-IV-administered medication just as effective in stopping seizures
7. The Infrex Plus is Revolutionizing Pain Control by Stopping Pain & Eliminating Drugs for Chronic Pain Patients Who Suffered For Years
8. Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
9. Surgery May Boost Survival With Dangerous Heart Condition
10. Tests to catch the makers of dangerous legal high designer drugs
11. Herbal supplements may cause dangerous drug interactions in orthopaedic surgery patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... Image ... business to a new market, and it’s the buildings of Nashville that will benefit. ... when I needed to relocate to Nashville, there was no question that I would ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... advocates will discuss how to improve care by making data on heart procedures ... disease. The Summit on Transparency and Public Reporting of Pediatric and Congenital Heart ...
(Date:2/11/2016)... Plantation, Fla. (PRWEB) , ... February 11, 2016 ... ... CareTRAK™, an unparalleled clinical decision support technology, with highly adaptable algorithms, has ... cases. When a patient has signs and symptoms consistent with Zikas and a ...
(Date:2/11/2016)... ... February 11, 2016 , ... Life is known for ... men, 60 and older, who gather once a year to play softball to raise ... for the game, the more than 50 players who competed in this year’s softball ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... practice Village Family Practice , will be presenting at the 2016 HIMSS ... Las Vegas, Nev. , During his session, “ Coding for Care: Using ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016  MiMedx Group, Inc. (NASDAQ: MDXG ), ... and other birth tissues, human skin and bone, and ... advanced products and therapies, announced today that it will ... Conference in New York , NY.  ... J. Senken , Chief Financial Officer and Chris ...
(Date:2/11/2016)... 11, 2016  AfterPill.com is reporting that this week,s ... for all women who are at risk of unintended ... year and raises the risks of unprotected sex in ... According to the Guttmacher Institute, there are 43 ... child-bearing age, who have sex without the intention of ...
(Date:2/11/2016)... Wearable posture tracker, ALEX , has taken Kickstarter by storm, crowdfunding over $60,000 – or 120% ... ALEX is said to be delivered to backers starting May of this year. ... ... ... Created by NAMU, a team of biomedical engineers out ...
Breaking Medicine Technology: