Navigation Links
Stopping dangerous cell regrowth reduces risk of further heart attacks
Date:12/6/2011

"After an arterial injury, the inner layer of cells in the artery begins to regrow. In the long term, this usually causes more harm than good", says Maria Gomez.

A common cause of arterial injuries is the clearing of blocked arteries often performed on patients who have had a heart attack.

"Initially the artery is opened up, but after a while new cell formation increases the risk of further heart attacks."

In animal experiments, the research groups have demonstrated the opposite effects of the two proteins. The carotid artery of rats was damaged with balloon dilation, simulating the procedure carried out on heart attack patients.

After two weeks, there was noticeably less new cell formation in the arteries that had more of the protein IRT-1. With AIF-1, the opposite effect was observed.

"The interesting thing is that both proteins are formed from the same gene and we have now found a mechanism to control the balance in the formation of the two. Using a new drug we can thus increase the amount of the 'good' protein, IRT-1. It is not an approved drug, but it has been tested on mice and appears to be tolerated well", says Maria Gomez.

The researchers have also analysed over 150 fatty deposits ('plaques') removed from the carotid arteries of patients.

"We saw that the dangerous plaques those that are unstable, easily rupture, are more inflamed and more often produce symptoms contain more AIF-1. Those with a higher proportion of the protein IRT-1 are less dangerous", observes Lisa Berglund, co-author of the published study.

Diabetes patients develop more plaques, and more often dangerous ones, than non-diabetics. Diabetics have a significantly higher risk of suffering a heart attack.

The regrowth of cells in the arteries also leads to negative changes in blood flow. It may even be the case that AIF-1 is involved in the actual formation of plaques in the arteries.

Heart attacks are the most common cause of death in Sweden and many patients have repeated attacks, which are treated by clearing constrictions in the arteries of the heart using various methods.

"If we could reduce the risk of repeat attacks, this would represent very significant progress", says Maria Gomez.


'/>"/>
Contact: Maria Gomez
Maria.Gomez@med.lu.se
46-702-226-216
Lund University
Source:Eurekalert

Related medicine news :

1. Stopping Daily Aspirin Boosts Heart Attack Risk: Study
2. ACP commends Congress for preserving patient access by stopping scheduled Medicare SGR cuts
3. Internists issue heartfelt plea for Congress to help patients by stopping Medicare SGR cuts
4. Researchers find new target for stopping tumors developing their own blood supply
5. Stopping smoking cessation treatments too soon may reduce odds of success for 45 percent of smokers
6. Non-IV-administered medication just as effective in stopping seizures
7. The Infrex Plus is Revolutionizing Pain Control by Stopping Pain & Eliminating Drugs for Chronic Pain Patients Who Suffered For Years
8. Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
9. Surgery May Boost Survival With Dangerous Heart Condition
10. Tests to catch the makers of dangerous legal high designer drugs
11. Herbal supplements may cause dangerous drug interactions in orthopaedic surgery patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... TransactRx announces the release of ... medical service claims by Pharmacy Benefit Managers that were submitted by Retail Clinics ... TransactRx Cross Benefit Clearinghouse receives standard professional medical claims submitted from the retail ...
(Date:5/25/2016)... FRANCISCO, CA (PRWEB) , ... May 25, 2016 , ... ... School of Nursing and Health Professions. She will lead a team of more than ... Team. Baker will begin her role as dean in late August. , Baker comes ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Laser ... to help turn back the hands of time of female aging. The ... childbirth. Women with symptoms such as leakage, laxity, itchiness and pain have reported ...
(Date:5/25/2016)... NJ (PRWEB) , ... May 25, 2016 , ... Researchers ... 2016 Annual COVD Meeting for their work on visual evoked potential and human attention. ... recent studies that used the Diopsys® NOVA™ ERG and VEP Vision Testing System ...
(Date:5/25/2016)... ... May 25, 2016 , ... HealthPostures ... will join America's leading engineers at the American Society of Safety Engineers Conference ... Congress Center. , Engineers, speakers and exhibitors from more than 40 countries ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 24, 2016 Niederländische Chirurgen ... die es Ärzten erlaubt, ihre Expertise weltweit zu ... kombiniert Live Streaming mit einer Instant-Messaging-Funktion und der ... Mediziner in Europa, Afrika, Asien und den ... die Plattform registriert. Information und Weiterbildung   ...
(Date:5/24/2016)... 2016  Diana Russell suffers from a form of ... inside out.  This disease has put her in a ... and grandchildren to leave her home.  Because of the ... haul the wheelchair.  So if there is a family ... is left to wait for the bus. ...
(Date:5/24/2016)... Marziani has joined VMS BioMarketing as senior vice president of sales, announced Andrea ... Marziani will lead the company,s business development and sales team, exploring new opportunities for ... - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
Breaking Medicine Technology: