Navigation Links
Stopping dangerous cell regrowth reduces risk of further heart attacks
Date:12/6/2011

"After an arterial injury, the inner layer of cells in the artery begins to regrow. In the long term, this usually causes more harm than good", says Maria Gomez.

A common cause of arterial injuries is the clearing of blocked arteries often performed on patients who have had a heart attack.

"Initially the artery is opened up, but after a while new cell formation increases the risk of further heart attacks."

In animal experiments, the research groups have demonstrated the opposite effects of the two proteins. The carotid artery of rats was damaged with balloon dilation, simulating the procedure carried out on heart attack patients.

After two weeks, there was noticeably less new cell formation in the arteries that had more of the protein IRT-1. With AIF-1, the opposite effect was observed.

"The interesting thing is that both proteins are formed from the same gene and we have now found a mechanism to control the balance in the formation of the two. Using a new drug we can thus increase the amount of the 'good' protein, IRT-1. It is not an approved drug, but it has been tested on mice and appears to be tolerated well", says Maria Gomez.

The researchers have also analysed over 150 fatty deposits ('plaques') removed from the carotid arteries of patients.

"We saw that the dangerous plaques those that are unstable, easily rupture, are more inflamed and more often produce symptoms contain more AIF-1. Those with a higher proportion of the protein IRT-1 are less dangerous", observes Lisa Berglund, co-author of the published study.

Diabetes patients develop more plaques, and more often dangerous ones, than non-diabetics. Diabetics have a significantly higher risk of suffering a heart attack.

The regrowth of cells in the arteries also leads to negative changes in blood flow. It may even be the case that AIF-1 is involved in the actual formation of plaques in the arteries.

Heart attacks are the most common cause of death in Sweden and many patients have repeated attacks, which are treated by clearing constrictions in the arteries of the heart using various methods.

"If we could reduce the risk of repeat attacks, this would represent very significant progress", says Maria Gomez.


'/>"/>
Contact: Maria Gomez
Maria.Gomez@med.lu.se
46-702-226-216
Lund University
Source:Eurekalert

Related medicine news :

1. Stopping Daily Aspirin Boosts Heart Attack Risk: Study
2. ACP commends Congress for preserving patient access by stopping scheduled Medicare SGR cuts
3. Internists issue heartfelt plea for Congress to help patients by stopping Medicare SGR cuts
4. Researchers find new target for stopping tumors developing their own blood supply
5. Stopping smoking cessation treatments too soon may reduce odds of success for 45 percent of smokers
6. Non-IV-administered medication just as effective in stopping seizures
7. The Infrex Plus is Revolutionizing Pain Control by Stopping Pain & Eliminating Drugs for Chronic Pain Patients Who Suffered For Years
8. Drug May Dampen Dangerous Side Effect of Stem Cell Transplants
9. Surgery May Boost Survival With Dangerous Heart Condition
10. Tests to catch the makers of dangerous legal high designer drugs
11. Herbal supplements may cause dangerous drug interactions in orthopaedic surgery patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... December 09, 2016 , ... The American Speech-Language-Hearing Association ... a critical part of public access to hearing aid technology. , ASHA emphasized ... week that, starting immediately, it would no longer enforce the requirement that ...
(Date:12/9/2016)... ... December 09, 2016 , ... "I have gout, and I wanted to ... recipe, which is meant to relieve gout and pain caused by varicose veins. I ... boost every time. It relieved what VA doctors called the worst sinusitis case they'd ...
(Date:12/9/2016)... ... December 09, 2016 , ... Mediaplanet today announces distribution of the latest edition ... to sign up as an organ donor for the 123,000 people in the United ... donor can save up to 8 saves through organ donation and enhance many others ...
(Date:12/9/2016)... ... December 09, 2016 , ... The Pennsylvania Athletic ... (PCN) during the summer of 2016. The program was made possible by a ... States Department of Health and Human Services Administration. The broadcast, Use Your ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... LLC, announced the first national #QuackGivesBack campaign which supported local breast cancer organizations ... first franchise-wide Quack Gives Back initiative, and we’re very pleased with ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... Australia Ophthalmic Lasers Market Outlook to 2022 Summary ... to 2022", provides key market data on the Australia ... of US dollars, volume (in units) and average prices ... and YAG Lasers. The report also provides company ... market segements, and global corporate-level profiles of the key ...
(Date:12/8/2016)... Dec. 8, 2016  The global biosurgery market is ... the forecast period of 2016 to 2021. The market ... from USD 18.21 billion in 2016. The market is ... of sports related injuries and spinal problems, increasing clearance ... of effective blood loss management. In this ...
(Date:12/8/2016)... Dec. 8, 2016 KEY FINDINGS ... share of the market in 2016 and is expected ... be attributed to a large number of surgical procedures ... the largest share in the patient temperature management market.) ... as reducing loss of blood during surgeries, lowering the ...
Breaking Medicine Technology: