Navigation Links
Stopping a receptor called 'nogo' boosts the synapses
Date:3/18/2008

he growth of neurons in the spinal cord. For most of this decade, scientists have worked to target the molecule, thinking that if they could block it, they could possibly regenerate nerves, repairing spinal cord damage in a way that is impossible today.

But that road has proved difficult. Last year in the same journal, the Rochester team led by Giger showed that while the nogo receptor does play a role in preventing spinal nerves from growing, it does not control the process outright. While nogo receptor activation can transiently stunt the growth of neurons, it is not required for chronic outgrowth inhibition of injured nerve cells.

Gigers team has found that in some areas of the brain, such as the hippocampus, the nogo receptor is at least 10 times more prevalent than in the spinal cord.

In the brain, Gigers team found that the nogo receptor wields broad influence over a process known as neuroplasticity, which describes how our brain cells change and adapt constantly to meet our needs. It can be thought of simply as the brains ability to rewire itself on the fly to meet the demands of an organism. The process explains why people are able to recover many of their abilities even after a traumatic brain injury or a stroke: Other brain cells pick up the work for the ones that have died.

Gigers team found that the nogo receptor plays an important role in changing the brain in two ways.

First, the molecule plays a completely unexpected role manipulating the strength of signals between brain cells in the synapses. A team led by Peter Shrager, Ph.D., professor of Neurobiology and Anatomy, made sophisticated measurements of the strengths of the signals as they passed from cell to cell in mice. They found that mutant mice with fewer nogo receptors than normal had stronger brain signaling, what scientists call long-term potentiation.

The molecule also affected tiny structures known as dendritic spines, crucial connectio
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Fugitive cancer cells can be blocked by stopping blood cells that aid them
2. Physicians focus on stopping pain epidemic
3. First 90 Days After Stopping Plavix Most Dangerous
4. New Booklet Reveals 12 Proven Methods for Stopping MRSA from Infecting Your Feet and Your Familys Feet
5. New Sedona Stopping Diabetes Program
6. Common drug for stopping preterm labor may be harmful for babies
7. Hands2GO(R) Hand Sanitizer Offers Alcohol-Free Alternative to Stopping the Spread of Flu at School and Work
8. On 30th Anniversary, Angioplasty Celebrated as Modern Medical Breakthrough in Stopping Heart Attack
9. Stopping Tysabri May Worsen MS
10. Stopping Statins After Stroke Doubles Death Risk
11. Pain receptor in brain may be linked to learning and memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... (PRWEB) March 05, 2015 Kevin Batsford ... by the grips of drug addiction. The siblings frequented ... their habits, and to seek refuge during the night. ... drugs, without consideration for his outward appearance, hygiene, or ... substances. CNY Central reported on Feb. 23rd ...
(Date:3/5/2015)... 05, 2015 The law firm of ... of the upcoming Crain’s Chicago Business Physicians' Breakfast on ... Breakfast will take place from 7:30 to 9:45 a.m. ... Chicago, IL 60611. The morning’s events will include a ... professionals. , The panel discussion is focused on ...
(Date:3/5/2015)... Wilmington, DE (PRWEB) March 05, 2015 ... and false weight loss promises is alarming, with more ... and products without an actual prescription, making it easy ... scams that simply take their money and endanger their ... simple questions before purchasing prescription online diet pills: , ...
(Date:3/5/2015)... Colorful packaging and marketing promises make it hard ... But all it really takes is reading the ingredient ... March 2015 Harvard Health Letter . , "Go ... of the Department of Nutrition at Harvard-affiliated Brigham and ... the markers of good nutrition. , Whole grains should ...
(Date:3/5/2015)... 2015 Daily Greens™, an organic ... smoothie line, Half Pint that will debut nationwide, ... Greens’™ current offerings, Half Pint is crafted with ... and other ingredients that are sourced locally whenever ... To preserve nutrients and extend shelf life, the ...
Breaking Medicine News(10 mins):Health News:The Homeless’ Unaddressed Drug Addiction Continues to Spiral Out of Control, Harbor Village Detox Stresses Treatment for the Homeless 2Health News:The Homeless’ Unaddressed Drug Addiction Continues to Spiral Out of Control, Harbor Village Detox Stresses Treatment for the Homeless 3Health News:Cook County Law Firm to Sponsor Physicians Breakfast 2Health News:Diet Doc Announces Four Simple Questions that Dieters Must Ask Prior to Purchasing Online Diet Pills 2Health News:Diet Doc Announces Four Simple Questions that Dieters Must Ask Prior to Purchasing Online Diet Pills 3Health News:Tips to Find the Healthiest Breakfast Cereals, From the March 2015 Harvard Health Letter 2Health News:Daily Greens™ Debuts Organic Cold-Pressed Smoothie Line for Kids Exclusively in Whole Foods Markets 2Health News:Daily Greens™ Debuts Organic Cold-Pressed Smoothie Line for Kids Exclusively in Whole Foods Markets 3
... less likely to be ... the average worker, SCHAUMBURG, Ill., May 5 While ... living toiling in the sun face an,increased threat of skin ... Now, new research finds that workers who,need skin exams the ...
... in Kenya, Uganda, Tanzania Use Integrated Approach, ... of East,Africa -- including Uganda, Kenya, and ... pressures, poor health services, and environmental,degradation. But ... projects to more efficiently address,these linked problems., ...
... WASHINGTON, May 5 The Association of ... (D-CT), Orrin,Hatch (R-UT) and Hillary Clinton (D-NY), ... Mike Simpson (R-ID) on the president,signing into ... and,health care provider education, improved follow-up care ...
... clarifies a previously poorly understood key event in the ... Press in the May issue of the journal Cancer ... breast tumor progression and suggests that it may be ... solely on the tumor cells but are also targeted ...
... Michael Leahy tells his personal story and seeks,to put ... 5 It is accessible from,anywhere. It has permeated ... our homes. An estimated 40 million American adults regularly ... of sex and,the porn industry in the U.S. were ...
... Snoring also related to problem, researchers report , , MONDAY, May ... have elevated levels of a heart hormone that helps regulate ... , Additionally, children who habitually snore are about three times ... snore, but the severity of snoring appears to have little ...
Cached Medicine News:Health News:Warning: New Skin Cancer Study Finds Outdoor Workers are Less Likely to Get Screened for Skin Cancer 2Health News:Warning: New Skin Cancer Study Finds Outdoor Workers are Less Likely to Get Screened for Skin Cancer 3Health News:Warning: New Skin Cancer Study Finds Outdoor Workers are Less Likely to Get Screened for Skin Cancer 4Health News:East African Experts Discuss Population, Health, Environment at Wilson Center 2Health News:Association of Public Health Laboratories Applauds Signing of Newborn Screening Saves Lives Act 2Health News:Scientists identify 'gatekeepers' of breast cancer transition to invasive disease 2Health News:Porn Nation Uncovers the Sexualization of America 2Health News:Heart Hormone Elevated in Children Who Wet Bed 2Health News:Heart Hormone Elevated in Children Who Wet Bed 3
(Date:3/5/2015)... VANCOUVER, British Columbia , March 5, 2015 ... BMKDF) -- The ultimate goal in the cancer diagnostics ... of detecting tumors before they become disruptive, metastatic and ... such an assay has been the holy grail ... many breakthrough diagnostics have been invented such as ELISA-based ...
(Date:3/4/2015)... 4, 2015  Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... of the Phase II proof of concept clinical ... as a monotherapy in the treatment of chronic ... highly significant and clinically meaningful improvement from baseline ... measured on a 100mm unit Visual Analog Scale ...
(Date:3/4/2015)... 4, 2015 GSI Group Inc. (NASDAQ: ... global leader and supplier of precision photonics and motion ... advanced industrial technology markets, today reported financial results for ... noted, all financial results in this press release are ... QuarterDuring the fourth quarter of 2014, GSI generated revenue ...
Breaking Medicine Technology:New Cancer Diagnostic Primed to Change the Industry 2New Cancer Diagnostic Primed to Change the Industry 3New Cancer Diagnostic Primed to Change the Industry 4Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 2Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 3Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 4Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 5Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 6Vanda Pharmaceuticals Announces Tradipitant Phase II Proof of Concept Study Results for Chronic Pruritus in Atopic Dermatitis 7GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 2GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 3GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 4GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 5GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 6GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 7GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 8GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 9GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 10GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 11GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 12GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 13GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 14GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 15GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 16GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 17GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 18GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 19GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 20GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 21GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 22GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 23GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 24GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 25GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 26GSI Group Announces Financial Results for the Fourth Quarter and Full Year 2014 27
... Isotopes Inc (OTC Bulletin Board: INIS ) announces ... general business status, particularly, the year to date performance of ... of its ongoing plans for the depleted uranium de-conversion project. ... When: Wednesday, September 14 – 3:00PM ...
... 2011 The Educational Review System announces the pediatric ... Gaps — Where do we go from here?" – ... first annual Pediatric Medication Safety Summit, will focus on ... benefits of technology and the gaps. ...
Cached Medicine Technology:International Isotopes Inc Announces Conference Call to Give an Update on the Company's General Business Status 2
Engineered for high volume surgical efficiencies, the Bausch & Lomb Hansatome Microkeratome, a corneal resection instrument, features an automated pivoting motion that provides smooth, resistance-fre...
... The Brilliance 64-channel configuration breaks through ... large volume, thin-slice coverage to improve ... , ,With 40mm of thin-slice coverage, ... imaging, allowing for unprecedented coronary artery ...
Assay for Anti-HTLV-I and Anti-HTLV-II...
InBios' Trypanosoma cruzi (chagas disease) is an ELISA system for the detection of antibodies to T.cruzi derived TcF antigen in human serum or plasma This test is intended for professional in vitro d...
Medicine Products: