Navigation Links
Stopping Controversial Asthma Drugs Could Have Downside: Study
Date:8/27/2012

By Randy Dotinga
HealthDay Reporter

MONDAY, Aug. 27 (HealthDay News) -- It's OK for some patients with asthma to stick with a combination of medications instead of abandoning one because of concerns about complications, a new analysis of existing research suggests.

The U.S. Food and Drug Administration has warned that asthma patients who take both long-acting beta-agonist and inhaled corticosteroid medications should be cautious about using them together once their condition is under control.

Long-acting beta-agonists -- such as drugs known by the brand names Serevent, Foradil and Brovana -- could cause side effects, the FDA cautioned, as could combination drugs. For that reason, the agency suggested that patients consider going with inhaled corticosteroids alone.

However, the new analysis came to a different conclusion. "Adding a long-acting beta-agonist to an inhaled corticosteroid medication makes a lot of sense in a number of patients since you get better control of the disease," said Dr. Thomas Casale, chief of allergy and immunology at Creighton University, and lead author of the report.

The report was published online Aug. 27 in the journal Archives of Internal Medicine.

At issue is how to best treat adults and older children who suffer from moderate to severe asthma.

Inhaled corticosteroids, which come in inhalers and are known by brand names such as Azmacort and Flovent, are often prescribed by themselves to reduce wheezing and other symptoms. They're usually taken daily but don't relieve asthma attacks when they're occurring. (Short-acting beta-agonists, such as the drug albuterol, treat asthma attacks themselves.)

The newer long-acting beta-agonists are frequently used with inhaled corticosteroids. Some medications, sold under the brand names Symbicort and Advair, combine both types of drugs.

This latest analysis, which examined five studies involving patients aged 15 or older, found that removing a long-acting beta-agonist -- but continuing treatment with an inhaled corticosteroid -- was worse for patients than continuing both drugs.

Patients who dropped the long-acting beta-agonists reported more asthma problems and fewer days with no symptoms. The findings also suggested that these patients needed more treatment of asthma attacks. The studies, however, didn't allow researchers to examine the risk of death under the different approaches.

Casale said he doesn't think the FDA's concerns about death and other health problems -- which resulted in a bold warning on drug labels -- have deterred physicians from prescribing the combination treatments. However, he said, they have reinforced guidelines recommending against using the long-acting beta-agonists as treatments by themselves.

"I think all of us agree with that," he said. "They're only to be used in conjunction with an inhaled corticosteroid, and only in those who aren't adequately controlled."

In an accompanying journal editorial, Dr. Chee Chan and Dr. Andrew Shorr, both from the division of pulmonary and critical care medicine at Washington Hospital Center in Washington D.C., wrote that they hoped the analysis "helps to lift some of the black clouds" in the debate over the use of the asthma drugs.

More information

For more about asthma, visit the U.S. National Library of Medicine.

SOURCES: Thomas B. Casale, M.D., professor of medicine and chief, allergy and immunology, Creighton University, Omaha, Neb.; Aug. 27, 2012, Archives of Internal Medicine, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stopping Blood Thinners Raises Stroke Risk for Patients With Irregular Heartbeat
2. Stopping and starting cancer cell cycle weakens and defeats multiple myeloma
3. Opioid receptors as a drug target for stopping obesity
4. U.S. Gives Green Light to Publish Controversial Bird Flu Research
5. Controversial vaccine trial should never have been run in India, researchers say
6. Supreme Court Backs Much of Controversial Health Reform Law
7. Rapid Asthma Treatment in ER May Prevent Admission
8. Some Schools Dont Let Kids Carry Asthma Inhalers
9. Secondhand smoke continues to vex children with asthma
10. Many Asthmatic Kids Harmed by Secondhand Smoke: Study
11. Seniors Undertreated for Asthma, and Many Skip Inhalers: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stopping Controversial Asthma Drugs Could Have Downside: Study
(Date:3/24/2017)... ... 24, 2017 , ... As the standards bearer of advanced ... that positions them as the go-to thought leader in all matters concerning oncology ... an always-on, always-fresh news, views and advocacy engine, called ONS Voice. , The ...
(Date:3/24/2017)... ... ... Viewers who like to educate themselves on current issues and who enjoy ... societal issues tend to appreciate and love the "Informed" series, hosted by Rob Lowe. ... for causes around the world. , Running for charity has become a ...
(Date:3/24/2017)... ... , ... “Finding Christ Through Social Media: Year One #A365DayJourney ... writer’s path toward true communion with God. “Finding Christ Through Social Media: Year ... of published author Lea Michelle Johnson, a follower of Christ, wife and mother ...
(Date:3/24/2017)... ... March 24, 2017 , ... “The Adventures of Joey, The Dog ... dog who lives his life to the fullest, as God intended. “The Adventures of ... Holmgren, a mother and grandmother pursuing her passion for writing, especially about truth and ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... their communities, 16 more public health departments have been awarded national accreditation through ... 4.5 million people into the expanding network of communities across the nation whose ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... 2017 Research and Markets has announced the addition ... report to their offering. ... The IPF pipeline is very strong with a total of 97 drug ... Biogen and Sanofi are involved in the development of the IPF therapeutics. ... in Phase III stage, 15 are in Phase II stage, 12 are ...
(Date:3/24/2017)... A ReportsnReports.com report says, over the recent ... the global sales of Adcetris and Kadcyla have been witnessing rapid ... conjugates market is driven by large number of ADC drugs in ... offered by ADCs. ... Browse 3 Tables and 94 Figures, 10 Major Company Profiles, spread ...
(Date:3/24/2017)... March 24, 2017 Today Stock-Callers.com have ... which are: Neovasc Inc. (NASDAQ: NVCN), Hologic Inc. (NASDAQ: HOLX), ... SSH ). These companies are part of the ... on Thursday, March 23 rd , 2017, with the NYSE ... of health care companies in the S&P 500 were down ...
Breaking Medicine Technology: