Navigation Links
Stop signal discovered for skin cancer
Date:11/15/2011

An extraordinary breakthrough in understanding what stops a common form of skin cancer from developing could make new cancer treatments and prevention available to the public in five years.

In research published today in the leading international cancer journal, Cancer Cell, an international team of scientists led by Professor Stephen Jane and Dr Charbel Darido of Monash University's Department of Medicine at the Alfred Hospital, has discovered a gene that helps protect the body from squamous cell cancer (SCC) of the skin.

The Cancer Council estimates that two in three Australians will be diagnosed with skin cancer before the age of 70 with SCC being one of the most common forms. Up until now, its genetic basis has not been well understood, with surgical treatments the only option.

Professor Jane said the team discovered that a gene with an important role in skin development in the foetus is missing in adult SCC tumour cells. Although the researchers initially focused on skin cancer, they found that the protective gene is also lost in SCC that arises in other tissues, including head and neck cancers, that are often associated with a very poor outcome for the patient.

"Virtually every SCC tumour we looked at had almost undetectable levels of this particular gene, so its absence is a very profound driver of these cancers," Professor Jane said.

In collaboration with Associate Professor Rick Pearson from the Peter MacCallum Cancer Centre, the Monash researchers showed that loss of this particular gene knocks out the signal to stop skin cells from growing. Without this stop signal, the cells keep increasing in number and eventually forms a cancer.

Identifying this driver of cancer in skin and other organs provides a clear direction for developing strategies for both prevention and treatment in the relatively near future.

"Our research indicates that drugs already in clinical trials for other cancers may actually be effective in treating SCC - they just need to be applied to skin or head and neck cancers.

"This means that a number of the usual hurdles in getting therapies to trial have already been cleared, so patients could be reaping the benefits of this research in under five years," Professor Jane said.

"It's a similar case with prevention. There are strategies by which we could increase the expression of this gene that will likely afford some protection from skin cancer, for example in the form of a supplement in sun-cream. The molecules that would increase this expression, are very well validated, so there would be few barriers to applying them in clinical trials."


'/>"/>

Contact: Emily Walker
emily.walker@monash.edu
61-399-034-844
Monash University
Source:Eurekalert

Related medicine news :

1. Scientists identify genes that may signal long life in naked mole-rats
2. Embryonic signal drives pancreatic cancer and offers a way to kill it
3. Unraveling the complex signaling that helps cells know when to grow, when to sit tight
4. How major signaling pathways are wired to our genome gives new insight into disease processes
5. Oral Bacteria Might Signal Early Pancreatic Cancer
6. Stem cells, signaling pathways identified in lung repair
7. Bellowing Koalas Signal Size to Potential Mates
8. Certain Senior Moments May Signal Mental Decline
9. Key signal that prompts production of insulin-producing beta cells points way toward diabetes cure
10. Blood Protein Might Signal Death Risk in Elderly
11. Stop signal for leukemia stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2017)... ... July 22, 2017 , ... The arthroscopic superior ... the opportunity to return to sports and jobs that require heavy physical work, ... Medicine’s Annual Meeting in Toronto, Ontario, Canada. , “We studied 100 ...
(Date:7/21/2017)... ... 21, 2017 , ... The Wettstein Agencies, a central Colorado ... greater Denver region, is announcing a charity drive to help raise support for ... epilepsy. , Until a few months ago, Dominik was a healthy and happy ...
(Date:7/21/2017)... ... July 21, 2017 , ... The Karen ... services to communities in the greater Birmingham area, is joining the Chris Hammond ... young people in the region. , The Chris Hammond Youth Foundation maintains athletic ...
(Date:7/21/2017)... , ... July 21, 2017 , ... ... and Theater of Witness , was awarded a $300,000 grant from ... program which fosters empathy, comfort with ambiguity and the recognition of one’s own ...
(Date:7/21/2017)... ... ... The Margarian Law Firm has filed a class action lawsuit against ... no ginger. Dr. Pepper produces the “Canada Dry” brand of ginger ale products. In ... Ginger Ale claims on its bottle that it is made from real ginger. , ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... July 12, 2017 CarpalAID is a revolutionary new product ... surgery. Carpal tunnel syndrome affects more than 8 million ... the rate of men. The common methods of treating CTS are ... uncomfortable hand braces or gloves. ... CarpalAID is a clear patch worn on ...
(Date:7/11/2017)... July 11, 2017  Bayer has awarded grants totaling more ... part of its prestigious Bayer Hemophilia Awards Program (BHAP). Four ... Philadelphia and Uniformed Services University of the ... the winners. Grant recipients were announced last night during a ... 2017 Congress, Berlin, Germany . ...
(Date:7/11/2017)... July 11, 2017  Dr. Echenberg, founder of Echenberg Institute, is announcing ... patients who suffer from painful intercourse and other painful pelvic pain conditions ... due to menopause. ... VuVatech LLC ... Sarasota, Florida -based start-up company, VuVatech LLC, fills a ...
Breaking Medicine Technology: