Navigation Links
Stop signal discovered for skin cancer
Date:11/15/2011

An extraordinary breakthrough in understanding what stops a common form of skin cancer from developing could make new cancer treatments and prevention available to the public in five years.

In research published today in the leading international cancer journal, Cancer Cell, an international team of scientists led by Professor Stephen Jane and Dr Charbel Darido of Monash University's Department of Medicine at the Alfred Hospital, has discovered a gene that helps protect the body from squamous cell cancer (SCC) of the skin.

The Cancer Council estimates that two in three Australians will be diagnosed with skin cancer before the age of 70 with SCC being one of the most common forms. Up until now, its genetic basis has not been well understood, with surgical treatments the only option.

Professor Jane said the team discovered that a gene with an important role in skin development in the foetus is missing in adult SCC tumour cells. Although the researchers initially focused on skin cancer, they found that the protective gene is also lost in SCC that arises in other tissues, including head and neck cancers, that are often associated with a very poor outcome for the patient.

"Virtually every SCC tumour we looked at had almost undetectable levels of this particular gene, so its absence is a very profound driver of these cancers," Professor Jane said.

In collaboration with Associate Professor Rick Pearson from the Peter MacCallum Cancer Centre, the Monash researchers showed that loss of this particular gene knocks out the signal to stop skin cells from growing. Without this stop signal, the cells keep increasing in number and eventually forms a cancer.

Identifying this driver of cancer in skin and other organs provides a clear direction for developing strategies for both prevention and treatment in the relatively near future.

"Our research indicates that drugs already in clinical trials for other
'/>"/>

Contact: Emily Walker
emily.walker@monash.edu
61-399-034-844
Monash University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists identify genes that may signal long life in naked mole-rats
2. Embryonic signal drives pancreatic cancer and offers a way to kill it
3. Unraveling the complex signaling that helps cells know when to grow, when to sit tight
4. How major signaling pathways are wired to our genome gives new insight into disease processes
5. Oral Bacteria Might Signal Early Pancreatic Cancer
6. Stem cells, signaling pathways identified in lung repair
7. Bellowing Koalas Signal Size to Potential Mates
8. Certain Senior Moments May Signal Mental Decline
9. Key signal that prompts production of insulin-producing beta cells points way toward diabetes cure
10. Blood Protein Might Signal Death Risk in Elderly
11. Stop signal for leukemia stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Cooking and warming equipment ... of 5. This score reflects slightly positive negotiation conditions ... specialization, low switching costs and a low level of ... low availability of substitutes for cooking and warming equipment ... and aluminum, key inputs in the production process of ...
(Date:12/26/2014)... (PRWEB) December 26, 2014 “Many people ... with personal injury claim issues and phone calls with ... released an article featuring their free eBook on ... helpful eBook on pedestrian and bicycle auto accident claims ... is fully capable of professionally handling their case while ...
(Date:12/26/2014)... AZ (PRWEB) December 26, 2014 ... source for the best in heating, cooling and ... for 24 hour emergency services in 2014 with ... alike know that Arizona is known for its ... company that understands the intricacies and details of ...
(Date:12/25/2014)... 26, 2014 The report “Nintedanib ... 2023” focuses on the current treatment landscape, unmet ... colorectal cancer market. Stivarga is a drug which ... rectal cancer. Boehringer Ingelheim is developing nintedanib (BIBF-1120), ... of refractory CRC in the US, Europe, and ...
(Date:12/25/2014)... Recently, iFitDress.com, the popular online supplier of ... its new selection of black one-shoulder cocktail dresses . ... they are available at discounted prices, up to 70% off. ... last for three weeks only. You know, we have thousands ... interested in our new items can visit our website for ...
Breaking Medicine News(10 mins):Health News:Cooking & Warming Equipment Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Cooking & Warming Equipment Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Guide to Handling Pedestrian and Bicycle Accidents Released By The Jones Firm, Featured in Recent Article 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2
... Against the backdrop of last week,s Congressional hearing into ... at Buffalo,s Laboratory for Forensic Odontology Research in the ... on the controversial topic of bitemark analysis. The Congressional ... of Sciences (NAS) report on the scientific basis of ...
... Sept. 16 Managed Health Care Associates, Inc. (MHA), ... the country, today announced the immediate availability of RxPertise ... Regimen Review (MRR) software for consultant pharmacists in the ... efficiently manage the utilization, outcomes, and reporting requirements for ...
... abuse among undergrads, study shows , WEDNESDAY, Sept. 16 ... among university students, but an Internet-based intervention may help ... , Researchers analyzed data from a Web-based alcohol-use screening ... aged 17 to 24, in Australia, and found that ...
... The most important voice is YOURS! ... The Pennsylvania Breast Cancer Coalition (PBCC) Annual Conference will be held on ... 8:30 a.m. to 3:30 p.m. , , ... Pennsylvania Breast Cancer Coalition Annual Conference is the only statewide breast cancer ...
... , , , ... California hospital industry, El Camino Hospital CEO, Ken Graham, will provide insight ... Healthcare CEO Summit on Sept. 17 at 7:15 a.m. at the Rotary ... leadership, Graham has much to contribute to the health care reform debate. ...
... www.intelligenthospitals.com , , WINNIPEG, Sept. 16 ... pharmacy across North America, 77% of those looking to ... Intravenous Automation) - a self-contained unit for filling IV ... - as a vendor under consideration. The survey was ...
Cached Medicine News:Health News:Bitemark evidence and analysis should be approached with caution, according to UB study 2Health News:Bitemark evidence and analysis should be approached with caution, according to UB study 3Health News:MHA Announces Release of RxPertise(TM) 8.0 2Health News:Internet Can Help Curb Drinking Among College Students 2Health News:Pennsylvania Breast Cancer Coalition Hosts Annual Conference 2Health News:El Camino Hospital Provides Local Perspective on Health Care Reform and Innovation at Silicon Valley Healthcare CEO Summit 2Health News:IH Systems RIVA Top Pick for Directors of Pharmacy 2
(Date:12/24/2014)... -- ResMed (NYSE: RMD ) today announced its ... device manufacturer BMC Medical Co., Ltd. The ... below infringe ResMed,s patents, and entered an order prohibiting BMC ... the United States : , iVolve nasal ... nasal pillows mask , iVolve full face mask ...
(Date:12/24/2014)... , Dec. 23, 2014   Assurex Health, ... support to healthcare providers for behavioral health and ... secured $30 million in equity financing from new ... Drosos , President and Chief Executive Officer. ... and development of Assurex Health,s GeneSight ® ...
(Date:12/24/2014)... China , Dec. 23, 2014 ... pharmaceutical company that specializes in patented biopharmaceutical, modernized ... pharmaceutical ingredients (API) today announced that the Company ... its Good Manufacturing Practice (GMP) certificate of TPI,s ... Drug Administration,s (CFDA). The public notice period is ...
Breaking Medicine Technology:ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3
... Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59%... -- BEIJING, Aug. 16 /PRNewswire-Asia-FirstCall/ -- ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... { var s = ,; var first_result; // Results are keyed by longUrl, so we need to ...
... Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets -- LAIYANG, China, Aug. ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... var shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // ...
Cached Medicine Technology:Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 2Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 3Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 4Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 5Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 6Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 7Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 8Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 9Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 10Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 11Dehaier Medical Systems Q2 Revenue Up 46% to $4.83 Million; Net Income Up 59% to 1.14 Million; EPS 0.27 12Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 2Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 3Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 4Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 5Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 6Jiangbo Pharmaceuticals Announces the Commercial Launch of Felodipine Sustained Release Tablets 7
... The ABI Prism 7000 Sequence ... PCR system that detects and quantitates ... cycle-by-cycle detection of accumulated PCR product ... cycling, fluorescence detection, and application-specific software ...
RIA kit for the determination of autoantibodies to the TSH receptor (TSHR) in serum [with calibrators]....
ELISA kit for the determination of autoantibodies to the TSH receptor (TSHR) in serum....
Coated-Tube (CT) RIA kit for the determination of autoantibodies to the TSH receptor (TSHR) in serum...
Medicine Products: