Navigation Links
Stop diabetes with insulin tablets
Date:9/19/2012

Type 1 diabetes is the autoimmune form of diabetes, in which the patients' insulin-producing beta cells are destroyed by their own immune system.

"We know that if a person has two autoantibodies and one of them is against insulin, there is a 50 per cent risk that they will develop type 1 diabetes within five years. It doesn't matter how old you are", says ke Lernmark, Professor of Experimental Diabetes Research at Lund University in Sweden.

"There are indications that oral insulin may prevent or delay the clinical onset of type 1 diabetes among individuals with autoantibodies against insulin, who are thus in the risk zone", says ke Lernmark, who will be initiating and coordinating the Swedish TrialNet study.

ke Lernmark refers to a study presented earlier in the year by American and Canadian researchers. In the study, which ran from 1994 to 2003, participants with relatives who had type 1 diabetes and at least two autoantibodies, one of which against insulin, took either oral insulin or placebo capsules containing an inactive substance. At first, the results were a disappointment. Just as many people in the treatment group became ill as in the placebo group.

"However, the subsequent analyses showed something different. Among those who had high levels of insulin autoantibodies at the start of the study, the oral insulin had an effect and the development of type 1 diabetes was delayed. The delaying effect lasted for as long as the participants took the insulin", says ke Lernmark, adding that those who are now being recruited for the Swedish TrialNet study with oral insulin also have high levels of autoantibodies against insulin.

No one knows how oral insulin might stop type 1 diabetes. However, ke Lernmark believes a possible explanation could be that the immune system becomes accustomed to the low daily doses of insulin in the gastrointestinal tract. The insulin is not perceived as a foreign substance to be rejected by the immune system.

This line of reasoning is the same as for desensitisation for allergies, in which the dose of the substance that provokes the allergy is gradually increased.

The oral insulin study will run for several years and is open to all those who meet the requirements and are aged between 3 and 45.


'/>"/>

Contact: ke Lernmark
Ake.Lernmark@med.lu.se
46-706-164-779
Lund University
Source:Eurekalert

Related medicine news :

1. Belly Fat Adds to Diabetes Risk in Obese Adults, Study Finds
2. Aerobic Exercise Cuts Kids Diabetes Risk: Study
3. Bariatric surgery substantially reduces the risk of diabetes
4. Leading stem cell scientists to focus on diabetes, eye diseases at Cedars-Sinai symposium
5. Gestational Diabetes, Poverty Linked to ADHD
6. Single gene cause of insulin sensitivity may offer insight for treating diabetes
7. Hispanics May Face Higher Risk for Type 2 Diabetes: Study
8. Mass. Eye and Ear, Joslin Diabetes announce collaboration in eye care
9. Mobile apps for diabetes present usability issues for older adults
10. In Diabetes, Any Protein in Urine May Signal Heart Risk
11. Mayo Clinic: Diabetes can be controlled in patients after pancreas removal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... ... February 09, 2016 , ... Shark Finds and Kevin Harrington, and the Product ... GRIP-DRY. , GRIP-DRY is a newly patented product that has solved some of the basic ... wet and early morning dew or right after a rain shower, might understand the struggle ...
(Date:2/8/2016)... ... February 08, 2016 , ... CURE Media Group , the ... the Multiple Myeloma Heroes Awards event , which will annually honor individuals making ... patients with MM. The MM Heroes Awards nomination process is officially open ...
(Date:2/8/2016)... PA (PRWEB) , ... February 08, 2016 , ... ... expanded authorization with BASF Human Nutrition into the Food & Beverage ... BSI has been BASF’s channel partner throughout Canada and USA geographies east of ...
(Date:2/8/2016)... ... February 08, 2016 , ... Stephanie Hebert Insurance Agency, serving ... a new charity campaign. As part of their ongoing community involvement program, funds ... belief that children deserve a voice, and in the spirit of neighbors helping ...
(Date:2/8/2016)... ... ... who has struggled to quit smoking, a man who has struggled with hair loss – ... his problems – and he did. Now Nabat, a serial entrepreneur featured as the October ... to the world and better people's lives. His own experience with nicotine addiction led to ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... 2016 The new report " Global Fetal and Neonatal ... Business Research & Consulting group reveals that North America ... a share of 36.4% in 2014 that translated into revenues worth ... report also covers market analysis for Fetal and Neonatal care equipment ... Asia-Pacific , Latin America , ...
(Date:2/9/2016)... N.J. , Feb. 9, 2016  Bluestar Silicones ... (LSR) product line for long-term implant applications and ... Medical Design & Manufacturing (MD&M) West Conference (Booth ... --> --> ... Silbione® Biomedical LSRs offer outstanding physical properties enabling ...
(Date:2/8/2016)... Alzheimer Diagnostic Tests - Medical Devices ... Devices sector report , "Alzheimer Diagnostic Tests - ... of Alzheimer Diagnostic Tests currently in pipeline stage. ... pipeline products with comparative analysis of the products ... major players involved in the pipeline product development. ...
Breaking Medicine Technology: