Navigation Links
Stool DNA testing could play expanded role in colon cancer prevention
Date:5/4/2010

NEW ORLEANS -- Research teams led by Mayo Clinic have demonstrated for the first time that two types of colorectal pre-cancers can be detected through noninvasive stool DNA testing. The two studies being presented demonstrate that stool DNA testing may be useful for detection of premalignant dysplasia in patients with inflammatory bowel disease (IBD) and of an important type of colorectal pre-cancer called serrated polyps. The findings were presented at Digestive Disease Week 2010 (http://www.ddw.org/exhibitors), the annual meeting of the American Gastroenterological Association.

VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. David Ahlquist describing the research, are available on the Mayo Clinic News Blog (http://newsblog.mayoclinic.org/?p=3208&preview=true ). These materials also are subject to embargo, but may be accessed in advance by journalists for incorporation into stories. The password for this post is Ahlquist4.

David Ahlquist, M.D. (http://www.mayoclinic.org/bio/10006044.html), a gastroenterologist with Mayo Clinic and the senior investigator, said that sensitive stool DNA test methods developed at Mayo Clinic can detect common forerunners of colorectal cancer. "Detection of precursor lesions during screening is essential if cancer prevention is the goal," Dr. Ahlquist says.

Compared to widely used fecal blood tests, stool DNA testing has higher detection rates for curable stage colorectal cancer and for common precancerous polyps (called adenomas).

Detection of Colorectal Precancerous Lesions in Inflammatory Bowel Disease (Embargoed until DDW presentation, May 3, 2010, 5:30 p.m. CT)

The first study, presented on May 3 at Digestive Disease Week, involves identifying both cancer and a precancerous lesion, called dysplasia, in people who suffer from IBD. In a blinded study with 10 cases and 10 controls done in conjunction with Mount Sinai Medical Center and the University of Chicago, researchers found that stool DNA testing was positive in nine out of 10 cases (five of five with cancer, and four of five with dysplasia).

"This study shows that cancer and pre-cancer in IBD can be detected noninvasively," says Dr. Ahlquist. "The 90 percent detection rate by stool DNA testing is remarkable. It's important for people with IBD because they are at much higher risk for colorectal cancer than the general population. Given the limitations of colonoscopies in detecting these lesions, stool DNA testing could play a complementary role to improve the effectiveness of cancer surveillance."

Detection of Serrated Colorectal Polyps (Embargoed until DDW presentation, May 4, 3 p.m. CT)

The second study, presented on May 4, involves detecting serrated colorectal polyps. Unlike common adenomas, which usually protrude from the colon lining and are easy to see, serrated polyps are typically flat and the same color as the colon lining. Dr. Ahlquist says serrated polyps have been ignored or excluded from most screening studies to date because it wasn't clear they were associated with cancer. "Now they are regarded as the forerunner in roughly 30 percent of colon cancers," says Dr. Ahlquist. "Most of these are located on the right side of the colon, where screening has had less impact historically."

For this study, researchers first took tissue and identified two genetic markers that were present in serrated polyps but not in normal colon. The team assayed the markers (mutant BRAF and methylated vimentin genes) in stool samples from 14 cases and 19 control patients who had undergone screening colonoscopies. In blinded fashion, they compared results to fecal blood tests on the same specimens.

"We observed a 71 percent detection rate with stool DNA testing," says Dr. Ahlquist. "This was significantly higher than the 7 percent rate with conventional fecal blood tests."

"Detection of these important types of precancer by stool DNA testing offers promise in our efforts to more effectively and affordably prevent colorectal cancer ," says Dr. Ahlquist. "However, findings from both pilot studies need to be corroborated in larger studies."


'/>"/>

Contact: Amy Tieder
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Edifecs Testifies Before NCVHS Standards Subcommittee Regarding HIPAA 5010 and ICD-10 Testing
2. Doctors and Scientists Create New Society to Promote Non-Animal Toxicology Testing Methods
3. The Institute of Women's Health of North America to Offer Free Chlamydia Testing at All Affiliated Campuses – Dr. Abdul Rao
4. AXIOM Systems, Inc. Announces General Release of HIPAA 5010 Testing Solutions
5. ANY LAB TEST NOW North Dallas Lowers Diabetes Testing to $89
6. Refinement of glaucoma testing, treatment expected from US, United Kingdom study
7. Midbrook Lab Testing Provides Results for Cleaning Process Develop and Verification
8. Statement from American Water Works Association on the Environmental Working Group's report on Tap Water Quality Testing and Violations
9. Reportlinker Adds Peptic Ulcer Testing - A World Market Intelligence Report
10. Targeted Testing Receives Favorable Reviews On PADDS, Begins Nationwide Research Study On The Target Tests of Executive Functioning-OV
11. IQS Testing Purchased by The Compliance Management Group
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... ... May 06, 2016 , ... Logically, spring weather, with its moderate ... weather is too cold, dry or hot, water on the eye surface can evaporate, ... from the surrounding air. There’s only one problem, according to radio show and water ...
(Date:5/6/2016)... ... , ... The International Yoga Teacher Training schoo l will be ... to the town famous for its sunsets, Oia. This all inclusive yoga training retreat ... an amazing experience in Greece, we just can’t stay away” says Co-Founder Carri Uranga ...
(Date:5/6/2016)... ... May 06, 2016 , ... In honor of Military Spouse ... training, and the National Military Family Association, a nonprofit that works to strengthen ... full-tuition scholarship recipient of 2016. , “Being awarded this scholarship by Career ...
(Date:5/5/2016)... Aliso Viejo, CA (PRWEB) , ... May 05, 2016 , ... ... use in Final Cut Pro X. Drag and drop a TransWipe preset between two ... project. Choose from smooth corner wipes to colored panels with customizable color and orientation ...
(Date:5/5/2016)... ... May 05, 2016 , ... The U.S. ... cigarettes, requiring e-cigarette manufacturers to submit their products through an arduous federal approval ... vaping products that entered the market since February 15, 2007. That would essentially ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... Research and Markets has announced the addition of the  "Market ... to their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... Emission Tomography (PET) scanner and cyclotron install base in the ... France , Germany , ... United Kingdom . Along with the current ...
(Date:5/5/2016)... , May 5, 2016 ... addition of the  "Europe Thalassaemia Market and ... their offering.       (Logo: ... Europe Thalassaemia Market and Competitive Landscape Highlights ... pipeline products, Thalassaemia epidemiology, Thalassaemia market valuations ...
(Date:5/4/2016)... 2016 According to a new ... Interface Market - Global Industry Analysis, Size, Share, Growth, ... interface (BCI) market  is expected to reach a value ... to expand at a CAGR of 14.9 % during ... A BCI device provides collaboration between the brain and ...
Breaking Medicine Technology: