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Stool DNA testing could play expanded role in colon cancer prevention
Date:5/4/2010

NEW ORLEANS -- Research teams led by Mayo Clinic have demonstrated for the first time that two types of colorectal pre-cancers can be detected through noninvasive stool DNA testing. The two studies being presented demonstrate that stool DNA testing may be useful for detection of premalignant dysplasia in patients with inflammatory bowel disease (IBD) and of an important type of colorectal pre-cancer called serrated polyps. The findings were presented at Digestive Disease Week 2010 (http://www.ddw.org/exhibitors), the annual meeting of the American Gastroenterological Association.

VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. David Ahlquist describing the research, are available on the Mayo Clinic News Blog (http://newsblog.mayoclinic.org/?p=3208&preview=true ). These materials also are subject to embargo, but may be accessed in advance by journalists for incorporation into stories. The password for this post is Ahlquist4.

David Ahlquist, M.D. (http://www.mayoclinic.org/bio/10006044.html), a gastroenterologist with Mayo Clinic and the senior investigator, said that sensitive stool DNA test methods developed at Mayo Clinic can detect common forerunners of colorectal cancer. "Detection of precursor lesions during screening is essential if cancer prevention is the goal," Dr. Ahlquist says.

Compared to widely used fecal blood tests, stool DNA testing has higher detection rates for curable stage colorectal cancer and for common precancerous polyps (called adenomas).

Detection of Colorectal Precancerous Lesions in Inflammatory Bowel Disease (Embargoed until DDW presentation, May 3, 2010, 5:30 p.m. CT)

The first study, presented on May 3 at Digestive Disease Week, involves ident
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Contact: Amy Tieder
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

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