Navigation Links
Stomach Virus a Culprit in Chronic Fatigue Syndrome

Research was spurred by father's concern for son with debilitating condition

THURSDAY, Sept. 13 (HealthDay News) -- A father's concern for his son led to research that now sheds new light on a disease that has long been shrouded in mystery.

Andrew Chia, now 24, was diagnosed with debilitating chronic fatigue syndrome in 1997.

This week he is co-author with his father, Dr. John Chia, of a study which links chronic fatigue syndrome (CFS) with enteroviruses, which cause acute respiratory and gastrointestinal infections.

"This is sort of a new beginning. Now we can have development of antiviral drugs," said the elder Chia, an infectious disease specialist in private practice in Torrance, Calif. "We don't have anything for these poor people, although we've tried a number of things. Now we can study how these viruses behave and how we can kill them."

"Dr. Chia's data was on a substantial number of patients," said Dr. Nancy Klimas, a professor of medicine at the University of Miami Miller School of Medicine and director of the Gulf War Illness Center at the VA Medical Center. "This could send the field in a new direction."

The findings are published in the Sept. 13 online issue of the Journal of Clinical Pathology.

More than 1 million people in the United States are estimated to suffer from CFS, costing the nation some $9 billion annually. The condition is more common in women aged 40 to 60 and is marked by a cluster of debilitating symptoms, including unexplained fatigue, problems sleeping, problems with memory and concentration, and pain. CFS can be as disabling as multiple sclerosis.

The illness was first recognized in the late 1980s and, initially dubbed the "yuppie flu," has suffered from a credibility crisis. The causes of chronic fatigue syndrome (CFS) remain unclear.

Several different viruses, including Epstein-Barr virus, cytomegalovirus and parvovirus have been implicated, along with enteroviruses. There are more than 70 different types of enteroviruses that can affect the central nervous system, heart and muscles, all of which is consistent with the symptoms of CFS.

It was, however, difficult to find definitive proof of the viruses' presence. "That's how we judge a disease, if it causes organ damage or death, then it's a real disease," Chia said. "But if it doesn't show up, it doesn't mean it's not there."

Chia started on a Herculean task of drawing some 3,000 blood samples from patients, looking for viral genes. Over a period of five to six years, he found evidence of enteroviruses in 35 percent of patients, but this was after multiple samples from each patient. "If we were to take one sample from each patient, it would be less than 5 percent," Chia said. "We realized this wasn't the way to look at it. The assumption we made about CFS that we have to find the virus in their blood is totally wrong, so we started looking for the viruses in tissue, meat."

A team of European investigators had found enteroviruses in the brain, muscle and heart of a CFS patient who had committed suicide. But brain and heart biopsies are virtually impossible to perform in living people.

Chia started looking in the viruses' "area of replication," meaning the stomach. The viruses are resistant to stomach acids.

They eventually took stomach biopsies and performed endoscopies on 165 CFS patients, all of whom had had longstanding gastrointestinal complaints (these are common in CFS patients).

Eighty-two percent of the specimens from CFS patients tested positive for enteroviral particles, compared with just 20 percent of the samples from healthy people. In many patients, the initial infection had taken place years earlier (up to 20 years).

Partly, Chia's work was possible because of technological breakthroughs, Klimas pointed out. He also looked in the right "compartment."

"People were busy looking in the bloodstream, but he looked in the gut. He looked in the right compartment and, lo and behold, he found the viruses," she said. "It depends where you look, what you see."

Chia believes that enteroviruses may cause half of cases of CFS. The disease can also be triggered by other infections.

"It makes sense to me as an infectious disease. This makes all the sense in the world," he said. "If this is a virus, it doesn't destroy the cells, it hides inside the cells. It's one smart little virus."

Chia's son has recovered from the disease although, the elder Chia reported, "he spent a lot of time in the laboratory. Without him, I would not have done this."

More information

For more on chronic fatigue syndrome, visit the CFIDS Association of America.

SOURCES: John Chia, M.D., infectious disease physician, Torrance, Calif.; Nancy Klimas, M.D., professor, medicine, University of Miami Miller School of Medicine, and director, Gulf War Illness Center, VA Medical Center; Sept. 13, 2007, Journal of Clinical Pathology online

Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Lose stomach for Life....Preventive removal of stomach saves the risk of cancer
2. Animal Fat Enhances Risk Of Stomach
3. Leukemia pill shows promise against stomach cancer
4. Diet irregularities lead to stomach cancer
5. Fatty deposits affect the stomach too
6. Rumbling stomach
7. Methods to have a flat stomach
8. Animal Fat increases risk Of stomach cancer
9. Extracts of grapefruit heals stomach ulcers
10. Stomach infections may be associated with irregular heart rhythm
11. Grapefruit extract effective in stomach ulcer healing
Post Your Comments:
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... Scientists in ... tissue biopsy in 18 patients with or without mesothelioma. Surviving Mesothelioma has just posted ... , The doctors from PhenoPath Laboratories in Seattle and the University of British Columbia ...
(Date:10/13/2015)... ... , ... Tempe Dental Care, a leading Tempe dentists’ office, celebrates offering gentle, ... for more than 5 years. A leading cause of emergency room visits, school ... is not timely. , Sedation dentistry provides an anxiety-free dental experience ...
(Date:10/13/2015)... ... , ... Local Gold’s Gym franchise owner, Bryce Berry, received the Visionary of ... owns and operates Gold's Gym Cheyenne in Cheyenne, Wyoming, received the award ... States. A brand leader in global fitness, Gold’s Gyms are located worldwide. Every fitness ...
(Date:10/13/2015)... ... October 13, 2015 , ... Thermi, an ... newest professional to introduce the latest development, ThermiVa® temperature controlled radiofrequency to the ... professional in Obstetrics and Gynecology and a pioneer in the field of laparoscopy. ...
(Date:10/13/2015)... ... October 13, 2015 , ... In an ongoing effort ... , a Southlake, Texas, child development and pediatric therapy center, is working with ... families about their options for receiving this kind of care for affected children. ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... Ga. , Oct. 13, 2015  EndoChoice Holdings, ... its third quarter 2015 financial results on Thursday, November ... . --> . ... on Thursday, November 5, 2015 at 9:00 a.m. ET ... 328-5344 for domestic callers and (412) 317-5469 for international ...
(Date:10/13/2015)... --> --> ... from the Asthma and COPD Therapies market? Which areas are ... brand new report shows you potential revenues to 2025, assessing ... provides 260 tables, charts, and graphs. Discover the most lucrative ... new study lets you assess forecasted sales at overall world ...
(Date:10/13/2015)... 13, 2015  XiMo AG ( Lucerne ... Inc. ( Milpitas, California ) announced today ... chemistry. The importance of metathesis chemistry was highlighted by ... of this application. This industrially-relevant application has been utilized ... pharmaceuticals, specialty chemicals, and polymers. Georg Fráter ...
Breaking Medicine Technology: