Navigation Links
Stomach Cancer Tumors Have Genetic Differences: Researchers
Date:8/3/2011

WEDNESDAY, Aug. 3 (HealthDay News) -- Stomach cancer tumors have genetic differences, which determine how they respond to treatment, researchers have found.

In identifying two distinct versions of the disease, scientists found that a certain regimen of chemotherapy is more effective on one tumor type, while another drug works best on the other. The study authors said their findings would help doctors more effectively treat gastric cancer patients.

"Our study is the first to show that a proposed molecular classification of gastric cancer can identify genomic subtypes that respond differently to therapies, which is crucial in efforts to customize treatments for patients," study senior author Dr. Patrick Tan, associate professor in the Cancer and Stem Cell Biology Program at the Duke-National University of Singapore (NUS) Graduate Medical School, said in a university news release.

A microscopic pathology test developed in the 1960s, known as the Lauren classification, is a general description (either intestinal or diffuse) of how well the tumor cells clump together. The Singapore-based team at the Duke-NUS Graduate Medical School, however, was able to distinguish gastric cancer tumors where the Lauren test could not.

"There is a general assumption in the field that intestinal and diffuse gastric cancers [as classified by Lauren] represent two very different versions of gastric cancer, and now genomic data confirms this by demonstrating that the two genomic subtypes have very different molecular patterns," said Tan.

In profiling 37 stomach cancer cell lines, the researchers found two distinct patterns. Moreover, in accurately defining these tumor subtypes, they were also able to observe differences in how well each responded to chemotherapy.

"The exact mechanistic reasons for this difference are currently unclear, and this is an area that we are actively working on," noted Tan, adding that the researchers are working to find more specific vulnerabilities to drugs.

The researchers said they plan further research in which gastric cancer tumors will be genetically profiled to determine the most effective treatment.

The study findings were published in the Aug. 1 edition of Gastroenterology.

More information

The American Cancer Society has more about stomach cancer.

-- Mary Elizabeth Dallas

SOURCE: Duke-National University of Singapore Graduate Medical School, news release, Aug. 1, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Surgically shrinking the stomach when conservative weight-loss treatments fail
2. DNA from common stomach bacteria minimizes effects of colitis, U-M study says
3. Could Stomach Pacemaker Be New Weight-Loss Tool?
4. New fusion gene plays role in some stomach cancers
5. Heavy Beer Drinking, Genetics May Raise Risk of Stomach Cancer
6. Detection of early gastric cancer using hydro-stomach CT
7. How to Cope With Stomach Flu Symptoms
8. Common stomach bacteria may fight off inflammatory bowel disease caused by Salmonella
9. Stomach Ulcers Sending Fewer Americans to the Hospital
10. Western Diet Populates Kids Stomachs With Bad Bacteria
11. Simpler and cheaper antibiotic prophylaxis with insertion of nutrition catheter in the stomach
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stomach Cancer Tumors Have Genetic Differences: Researchers
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & Associates ... special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to date ... elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded by ...
(Date:10/13/2017)... ... , ... Many families have long-term insurance that covers care for a family ... for care if the client has a cognitive impairment diagnosis. , “What this ... often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, owner ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, ... and least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints ... for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... CHICAGO , Sept. 28, 2017 Hill-Rom ... quarter 2017 earnings conference call and webcast on Friday, ... 8:00 a.m. (EDT) and ending at approximately 8:30 a.m. ... to discussing the company,s 2017 financial performance and guidance ... growth opportunities, initiatives to enhance operational performance, and long-range ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
(Date:9/22/2017)... DIEGO , Sept. 22, 2017 AVACEN ... medical device is now successfully helping those with the ... Fibromyalgia diagnosed Amanda in Essex, ... dressed and washing my hair, experiencing no sleep at ... in painful spasm… I cannot recommend [the AVACEN 100] ...
Breaking Medicine Technology: