Navigation Links
Stimulating Thymus Reactivates T-Cell Production
Date:2/22/2008

Finding may provide benefit for HIV, bone marrow transplantation patients

FRIDAY, Feb. 22 (HealthDay News) -- It's possible to stimulate the thymus gland to produce new immune system T-cells in adults infected with HIV, U.S. researchers say.

HIV infection destroys T-cells, which leads to the collapse of the immune system and severe infection. The thymus gland produces T-cells early in life but gradually loses function and becomes mostly inactive in adulthood. That means it's difficult for HIV-infected adults to produce new T-cells to rebuild their depleted immune systems.

It has long been believed that it wasn't possible to reactivate T-cell production in the thymus. The new study, by researchers at the Gladstone Institute of Virology and Immunology and the University of California, San Francisco (UCSF), is the first to show that therapy can help boost thymus function in adults.

The two-year study of 22 HIV-infected adults found that treatment with growth hormone (GH) increased thymus mass and more than doubled the number of newly made T-cells. The results are published in the March issue of the Journal of Clinical Investigation.

"These results represent new proof-of-principle findings that thymic involution can be reversed in humans," study author Dr. Laura Napolitano, an assistant investigator at Gladstone and an assistant professor of medicine at UCSF, said in a prepared statement.

"Improved T-cell production may be helpful for some medical conditions such as HIV disease or bone marrow transplantation. These findings contribute new information to our understanding of T-cell production and are also an important step to determine whether immune therapies might someday benefit patients who need more T-cells," Napolitano said.

However, much more research is needed to determine whether stimulating production of new T-cells actually provides a health benefit for HIV patients or anyone else, the researchers said.

More information

The U.S. Centers for Disease Control and Prevention has more about HIV/AIDS.



-- Robert Preidt



SOURCE: Gladstone Institute, news release, Feb. 21, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. National Patient Advocate Foundation (NPAF) Statement Regarding New FDA Label on Erythropoietin Stimulating Agents (ESAs)
2. Stimulating muscles may improve musicians dystonia
3. Stimulating the appetite can lead to unrelated impulse purchases
4. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
5. EpiVax receives JDRF program funding to develop diabetes drug using natural regulatory T-cells
6. Simulating kernel production influences maize model accuracy
7. MedImmune Licenses Reverse Genetics Technology to GlaxoSmithKline for Use in Influenza Vaccine Development and Production
8. Three Batesville Casket Company Production Facilities Honored for Manufacturing Expertise by National Organizations
9. New study: pine bark extract boosts nitric oxide production
10. New ADDHERE(TM) Adhesive Tie Layer Bonds Acrylic Cap Layers to Substrates of Thermoplastic Polyolefin (TPO) in Production of Sheet for Use in Thermoforming
11. BLU-MED Response Systems Announces New Production Facility in Idaho
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stimulating Thymus Reactivates T-Cell Production
(Date:2/12/2016)... NV (PRWEB) , ... February 12, 2016 , ... Fisher ... Las Vegas Mayor John J. Lee, Nevada Military Support Alliance president Scott Bensing, and ... House at the VA Southern Nevada Healthcare System. This will be the first ...
(Date:2/12/2016)... ... February 12, 2016 , ... Young Asset ... celebrates the beginning of the latest charity campaign in their community enrichment program. ... Donations to this worthy cause are currently being accepted at: http://artexpressioninc.org/ . ...
(Date:2/12/2016)... New York, NY (PRWEB) , ... February 12, ... ... latest edition of “Revolutionizing Cancer Care.” , The print component of ... in Chicago, Dallas, Pittsburgh/Cleveland, New York, Washington DC/Baltimore, and Seattle, with a circulation ...
(Date:2/12/2016)... , ... February 12, 2016 , ... A lot has ... 35 years. A president has access to health and wellness resources most Americans could ... world, no single individual has a schedule as frenetic as the U.S. President. ...
(Date:2/12/2016)... ... February 12, 2016 , ... Basketball is a game for everyone, not ... Peety PoppersTM series, sign language translation is featured in the top right of the ... Peety PoppersTM lessons has a sign language translator to teach kids the game and ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... -- Wearable posture tracker, ALEX , has taken Kickstarter by storm, crowdfunding over $60,000 – or ... go, ALEX is said to be delivered to backers starting May of this year. ... ... ... Created by NAMU, a team of biomedical engineers ...
(Date:2/11/2016)... Transformational M&A achieved through NPS and ... --> Transformational M&A achieved through NPS and Dyax acquisitions ... Transformational M&A achieved through NPS and Dyax acquisitions and ... future growth with most robust pipeline in Shire , ... growth with most robust pipeline in Shire , ...
(Date:2/11/2016)... MEMPHIS, Tenn. , Feb. 11, 2016 ... a promising new treatment method at West Cancer ... low intensity electric fields to inhibit cancer cell replication ... therapy in more than a decade to show a ... adult Glioblastoma Multiforme (GBM) patients. Currently, West Cancer Center ...
Breaking Medicine Technology: