"These findings indicate there is a transient, not sustained, immune suppression in some children exposed to a new antigen at the same time as a corticosteroid administration," says Ducharme.
"In summary, our finding suggest a transient immune suppression occurs in some children who are concomitantly exposed to a new antigen and corticosteroids during an asthma attack, with a recovery within six weeks."
"Given the high frequency of use of these drugs over the past 20 years, the very rare occurrence of severe infectious disease is reassuring and would suggest that the window of risk is very small and only applies to exposure to a new antigen. However, before prescribing oral corticosteroids, it would appear prudent to systematically enquire about recent exposure to chickenpox in children who did not have chickenpox or the vaccine," adds Ducharme. Moreover, all children with asthma who have not had chickenpox should be vaccinated for this condition.
About asthma
The diagnosis of asthma, which is a chronic inflammatory disease of the lungs, has been significantly on the rise over the last few decades. In 2009, asthma caused approximately 250,000 deaths globally. However, with proper treatment, including the administration of inhaled bronchodilators and corticosteroids, all children with asthma can lead a normal life.
Corticosteroids are anti-inflammatory drugs and are used in asthma to reduce swelling. Strong scientific evidence shows that the use of these medications in patients with moderate to severe acute asthma significantly reduces the rate of hospitalizations and, if admitted, the length of stay in hospital. Consequently, these drugs are and should remain the cornerstone of the treatment of an acute asthma exacerbation.
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| Contact: William Raillant-Clark w.raillant-clark@umontreal.ca 514-343-7593 University of Montreal Source:Eurekalert |