Navigation Links
Steroids after surgery do not help infants with rare liver disease
Date:5/3/2014

Steroids after surgery do not help infants with rare liver disease

Infants with biliary atresia a rare liver disease did not benefit from corticosteroid treatment after bile duct surgery and could face more harm, according to a study funded by the National Institutes of Health. Results were published online May 3 in the Journal of the American Medical Association to coincide with the Pediatric Academic Societies annual meeting.

In biliary atresia, inflammation leads to blockage of the large bile ducts. Bile becomes trapped, causing damage to the liver and leading to scarring, loss of liver tissue and liver failure. Most infants with this serious disease require bile duct surgery and may later need a liver transplant. Worldwide, biliary atresia is the most common reason for liver transplantation in children.

The Steroids in Biliary Atresia Randomized Trial (START) set out to determine whether giving high-dose steroids to infants with biliary atresia after bile duct surgery (hepatoportoenterostomy, also known as the Kasai procedure) is better than surgery alone to maintain bile flow and preserve the children's livers.

Some previous studies suggested that using steroids after surgery reduced inflammation and scarring, promoting bile flow. Those studies became the foundation for widespread use of steroids after bile duct surgery in the United States and elsewhere. But the studies were limited in their ability to assess potential benefits and risks of using steroids in infants.

"We know that the surgery restores the flow of bile, relieves pain and delays the need for liver transplants in many infants, but we did not have data to prove that adding steroids significantly improved bile drainage in infants who had their own livers," said Averell H. Sherker, M.D., project scientist for the Childhood Liver D
'/>"/>

Contact: Leslie Curtis
NIDDKMedia@mail.nih.gov
301-496-3583
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Giving steroids during bypass surgery shows no benefit, some harm
2. Inhaled corticosteroids raise pneumonia risk
3. Allegheny Health Network Allergist Opposes OTC Sales of Corticosteroids in FDA Testimony, Citing Safety Concerns
4. Vitamin and Supplement Attorneys at Gilman Law, LLP Are Investigating FDA Claims of Anabolic Steroids As Ingredients in Healthy Life Chemistry by Purity First B-50
5. Generic Supplements Offers High Quality Pharmaceutical Grade Anabolic Steroids
6. Canakinumab allows discontinuation of corticosteroids in patients with SJIA
7. Fact or Fiction: Do Legal Steroids Work as Well as the Real Stuff?
8. COPD Patients May Do Fine With Shorter Course of Steroids
9. Anabolic steroids may affect future mental health
10. Certain Steroids May Raise Risk of Dangerous Blood Clots
11. Study: 15% of Children Ages 10 - 14 Consider Using Steroids; polyDNA Recommends Muxscle for Safe Muscle Building
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... strongly associated with Alzheimer,s disease; however, researchers are still ... causal agent of the onset and development of the ... beta-amyloid is not harmful when found in isolation but ... to form the so-called amyloid fibrils , "We are ... with multiple ones because each aggregate of peptide, which ...
(Date:10/1/2014)... 1, 2014 Patients with increased inflammation, including ... greatly increased risk of depression. For example, a ... hepatitis C virus infection causes depression in approximately ... more commonly known as fish oil, have a ... risk of heart disease and reducing triglyceride levels. ...
(Date:10/1/2014)... October 01, 2014 Insuranceragents.info has ... a good life insurance plan for vulnerable family members. ... vulnerable family members. Providers in the family should always ... cause financial hardships for the rest of the family. ... policies. Families can benefit more from temporary coverage or ...
(Date:10/1/2014)... ATLANTA (PRWEB) October 01, 2014 ... executive networking and relationship-marketing firm, announced today ... Security Executive® and Project of the Year ... decision makers representing organizations in financial services, ... include large-scale technology endeavors that address key ...
(Date:10/1/2014)... 01, 2014 Between 23 million and ... U.S., according to figures from the National Institutes of ... (AARDA), and many of them have something else in ... undiagnosed celiac disease. Gluten Free Therapeutics, makers of ... undiagnosed celiac disease by publishing a series of blog ...
Breaking Medicine News(10 mins):Health News:Laying siege to beta-amyloid, the key protein in Alzheimer's disease 2Health News:Omega-3 fatty acids may prevent some forms of depression 2Health News:Life Insurance for Families - Clients Can Compare Affordable Rates Online! 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3
... , , , ... BMR ), The Leading Provider of Real Estate to the Life Science ... ring The Closing Bell(R) at the New York Stock Exchange on Thursday, ... anniversary of the company,s initial public offering. The ceremony will take place ...
... Tinnitus Sufferer ... ... of a deep-sleep to a high pitch ringing sound in your ear, or constantly hearing ... reality for millions of men and women who suffer from the medical condition tinnitus, often ...
... ... marketplace. , ... FL (PRWEB) August 6, 2009 -- Because prices and benefits for Medicare Supplement (Medigap) ... rates offered by GetOnlineQuotes.com are an affordable and viable option for those 65 and ...
... August 6, 2009 Comprehensive health reform proposals now before ... young adults ages 19-29 gain coverage, and such reforms ... coverage would not lose it, according to a new ... Americans through expansions in Medicaid and a health insurance ...
... Addison, TEXAS, Aug. 5 U L URU ... today announced that it has scheduled a conference call to discuss the second ... on Monday, August 17, 2009 at 9:00 a.m. Eastern Time. , , ... international callers dial (850) 429-1388 (access code 23453#) five to ten minutes prior ...
... , , MENLO PARK, Calif., ... announced that it has provided written notice to The NASDAQ Stock ... stock from the NASDAQ Global Market. The Company currently anticipates that, ... the Securities and Exchange Commission and NASDAQ a Form 25 relating ...
Cached Medicine News:Health News:BioMed Realty Trust Commemorates Five-Year Anniversary as a Public Company 2Health News:BioMed Realty Trust Commemorates Five-Year Anniversary as a Public Company 3Health News:BioMed Realty Trust Commemorates Five-Year Anniversary as a Public Company 4Health News:BioMed Realty Trust Commemorates Five-Year Anniversary as a Public Company 5Health News:BioMed Realty Trust Commemorates Five-Year Anniversary as a Public Company 6Health News:BioMed Realty Trust Commemorates Five-Year Anniversary as a Public Company 7Health News:Lipo-Flavonoid Launches New Video Testimonial 2Health News:Lipo-Flavonoid Launches New Video Testimonial 3Health News:GetOnlineQuotes.com to Offer AARP/United Healthcare Medicare Supplement Insurance to Florida Residents 2Health News:Health reform proposals could help 13 million uninsured young adults gain coverage 2Health News:Health reform proposals could help 13 million uninsured young adults gain coverage 3Health News:ULURU Inc. Announces Conference Call to Discuss Financial Results for the Second Quarter Ended June 30, 2009 and to Provide a Business Update 2Health News:XTENT Announces Plan for NASDAQ Delisting and Filing of Certificate of Dissolution 2
(Date:10/1/2014)... and NOTTINGHAM, England , ... CBRX ) today announced that its subsidiary, Molecular ... Clinical Trials platform at the annual CPhI/ICSE Worldwide event ... aims to support companies with the rapid development of ... new enabling technologies screening platform, which incorporates the company,s ...
(Date:10/1/2014)... and NEW YORK , October 1, ... Research Organization (CRO) and service provider for the medical industries, announced ... of offices in New York City . genae ... City is strategically centered in one of the highest ... Coast", said Philippe Kassab , President at genae Americas. "The ...
(Date:10/1/2014)... 1, 2014 Trovagene, Inc., (NASDAQ:  TROV) ... that Eli Diamond , MD, Assistant Attending ... presented clinical data from an ongoing study demonstrating ... for the determination of oncogene mutational status in ... results were presented to both treating physicians and ...
Breaking Medicine Technology:Columbia Laboratories' UK Subsidiary To Launch New Development Platform At CPHI 2Columbia Laboratories' UK Subsidiary To Launch New Development Platform At CPHI 3genae Opens Offices in New York City 2Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 2Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 3Clinical Performance of Trovagene's Precision Cancer Monitoring Platform Presented at Second Annual International ECD Medical Symposium 4
... Roper Industries, Inc. (NYSE: ROP ) ... (CUSIP No. 776696AA4) (the "Notes") will accrue contingent interest for ... at an annual rate of 0.25% of the average market ... January 12, 2011. Contingent cash interest, which the Company has ...
... 18, 2011 Soligenix, Inc. (Soligenix or the ... a late-stage biopharmaceutical company, announced today promising preliminary ... beclomathasone dipropionate or BDP) in a canine gastrointestinal ... that dogs treated with SGX202 demonstrated statistically significant (p=0.04) ...
Cached Medicine Technology:Soligenix Announces Positive Preliminary Results of SGX202 in Radiation Injury 2Soligenix Announces Positive Preliminary Results of SGX202 in Radiation Injury 3Soligenix Announces Positive Preliminary Results of SGX202 in Radiation Injury 4Soligenix Announces Positive Preliminary Results of SGX202 in Radiation Injury 5
Indications For Usage: ,Single patient use on anesthetized patients and respiratory care patients who require a breathing circuit. The product is intended to be replaced at least once every 24 hours...
... helps provide protection to the exposed airway of ... lightweight making it ideal for active young children ... of heat and moisture recovery, it ensures patient ... and filters have ISO standard tapered ends to ...
... T helps provide protection to the exposed airway ... extremely lightweight making it ideal for active young ... rate of heat and moisture recovery, it ensures ... HMEs and filters have ISO standard tapered ends ...
... digital models cover the range from 2ul to ... Volume lock design prevents inadvertent volume change. ... grip. Whole pipette is autoclavable at 121C(250F). ... all polypropylene. Suitable for one-handed operation. ...
Medicine Products: