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Steps towards the use of adult stem cells for gene therapy
Date:10/13/2011

engineering, scientists were then able to correct the mutation responsible for the disease. They then engaged the now "healthy" stem cells in the maturation process, leading them to differentiate to liver cells.

Scientists from the Institut Pasteur and Inserm, led by Hlne Strick-Marchand in the mixed Institut Pasteur/Inserm Innate Immunity unit (directed by James Di Santo), then tested new human hepatic cells thus produced on an animal model afflicted with liver failure. Their research showed that the cells were entirely functional and suited to integration in existing tissue and that they may contribute to liver regeneration in the mice treated.

This groundbreaking work, published in Nature, thus strengthened hopes in scientific and medical communities regarding the use of iPS cells to treat humans.


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Contact: Marion Doucet
marion.doucet@pasteur.fr
01-456-88928
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

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